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Volumn 67, Issue 3, 2004, Pages 421-426

Resveratrol Derivatives and Their Role as Potassium Channels Modulators

Author keywords

[No Author keywords available]

Indexed keywords

BIBENZYL DERIVATIVE; DIHYDRORESVERATROL; POTASSIUM CHANNEL; POTASSIUM CHANNEL AFFECTING AGENT; RESVERATROL; RESVERATROL DERIVATIVE; SODIUM CHANNEL; STILBENE DERIVATIVE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

EID: 1642546976     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np0303153     Document Type: Article
Times cited : (56)

References (43)
  • 2
    • 0034468850 scopus 로고    scopus 로고
    • Stilbenes and bibenzyls with potential anti cancer or chemopreventive activity
    • Zappia V., Della Ragione F., Barbarisi A., Russo G. L., Eds.; Plenum Press: London, UK
    • (b) Orsini, F.; Verotta, L. Stilbenes and bibenzyls with potential anticancer or chemopreventive activity. In Advances in Nutrition and Cancer II; Zappia V., Della Ragione F., Barbarisi A., Russo G. L., Eds.; Plenum Press: London, UK, 1999; pp 169-186.
    • (1999) Advances in Nutrition and Cancer II , pp. 169-186
    • Orsini, F.1    Verotta, L.2
  • 26
    • 1642481132 scopus 로고    scopus 로고
    • note
    • 26) evidenced an overall quasi coplanar topography for the lowest energy conformation of trans-resveratrol; however, different orientations of the phenyl rings were accessible at a low energy cost (ΔE ca. 0.1-1.8 kcal/mol) also including the perpendicular ones with respect to the stilbenic double bond. The cis-configuration of the stilbenic double bond destabilizes the coplanar arrangement and forces one of the phenyl rings in an almost perpendicular orientation with respect to the stilbenic double bond. Analysis of dihydroresveratrol evidenced the presence of several quasi-transoid conformations of comparable energy (ΔE between 0.5 and 1.7 kcal/mol) which were different with respect to the orientation of the phenyl rings. Cisoid conformations for dihydroresveratrol were about 5-9 kcal/mol less stable, depending on the orientation of the phenyl rings. Dihydroresveratrol could therefore be able to mimic trans-resveratrol at a very low energy cost. Higher energy (5-9 kcal/ mol in the AM1 scale) would be required to mimic cis-resveratrol, a value, however, that, at least for some orientations of the phenyl rings, should not prevent the molecule from adopting this conformation if required for activity.
  • 37
  • 43


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.