Dynamics of thyroid-stimulating and -blocking antibodies to the thyrotropin receptor in a murine model of graves' disease

Endocrinology

Volumn 145, Issue 4, 2004, Pages 1539-1545

  Muehlberg, Tina ^a   Gilbert, Jacqueline A ^a   Rao, Prakash V ^a   McGregor, Alan M ^a   Banga, J Paul ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; PROTIRELIN; PROTIRELIN RECEPTOR; SYNTHETIC PEPTIDE; THYROTROPIN; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FIBROBLAST; GENETIC TRANSFECTION; GRAVES DISEASE; HYPERTHYROIDISM; IMMUNE RESPONSE; IMMUNIZATION; INBRED STRAIN; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MOUSE; MUTAGENESIS; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE MAPPING; PRIORITY JOURNAL; THYROTOXICOSIS;

ANIMALS; DISEASE MODELS, ANIMAL; EPITOPES; FEMALE; GRAVES DISEASE; HUMANS; IMMUNOGLOBULINS, THYROID-STIMULATING; MICE; MICE, INBRED STRAINS; RECEPTORS, THYROTROPIN;

EID: 1642546584     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1456     Document Type: Article

References (30)

1. Rees Smith B, McLachlan SM, Furmaniak J 1988 Autoantibodies to the thyrotropin receptor. Endocr Rev 9:106-121
2. Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM 1998 The thyrotropin receptor: interaction with thyrotropin and autoantibodies. Endocr Rev 19:673-716
3. Gupta MK 2000 Thyrotropin receptor antibodies in thyroid diseases: advances in detection techniques and clinical applications. Clin Chim Acta 293:1-29
4. Kraiem Z, Baron E, Kahana L, Sadeh O, Shinfeld M 1992 Changes in stimulating and blocking TSH receptor antibodies in a patient undergoing three cycles of transition from hypo to hyperthyroidism and back to hypothyroidism. Clin Endocrinol 36:211-216
5. Kasagi K, Hikada A, Endo K, Miyamoto S, Takeuchi R, Misaki T, Sakahara H, Konishi J 1993 Fluctuating thyroid function depending on the balance between stimulating and blocking types of TSH receptor antibodies: a case report. Thyroid 3:315-318
6. Takasu N, Yamashiro K, Komiya I, Ochi Y, Sato Y, Nagata A 2000 Remission of Graves' hyperthyroidism predicted by smooth decrease of thyroid stimulating antibody and thyrotropin binding inhibitor immunoglobulin during antithyroid drug treatment. Thyroid 10:891-896
7. Kung AWC, Lau KS, Kohn LD 2000 Characterization of thyroid stimulating blocking antibodies that appeared during transient hypothyroidism after radioactive iodine therapy. Thyroid 10:909-917
8. Kim WB, Chung HK, Lee HK, Kohn LD, Tahara K, Cho BY 1997 Changes in epitopes for thyroid stimulating antibodies in Graves' disease sera during treatment of hyperthyroidism: therapeutic implications. J Clin Endocrinol Metab 82:1953-1959
9. Kung AWC, Jones BM 1998 A change from stimulatory to blocking antibody activity in Graves' disease during pregnancy. J Clin Endocrinol Metab 83:514-518
10. Shimojo N, Kohno Y, Yamaguchi K, Kikuoka S, Hoshioka A, Niimi H, Hirai A, Tamura Y, Saito Y, Kohn LD, Tahara K 1996 Induction of Graves'-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule. Proc Natl Acad Sci USA 93:11074-11079
11. Costagliola S, Rodien P, Many MC, Ludgate M, Vassart G 1998 Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor. J Immunol 160:1458-1465
12. Costagliola S, Many MC, Denef JF, Pohlenz J, Refetoff S, Vassart G 2000 Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease. J Clin Invest 105:803-811
13. Kaithamana S, Fan J, Osuga Y, Liang SG, Prabhakar BS 1999 Induction of experimental autoimmune Graves' disease in BALB/c mice. J Immunol 163:5157-5164
14. Kita M, Ahmad L, Marians RC, Vlase H, Unger P, Graves PN, Davies TF 1999 Regulation and transfer of a murine model of thyrotropin receptor antibody mediated Graves' disease. Endocrinology 140:1392-1398
15. Nagayama Y, Kita-Furuyama M, Ando T, Nakao K, Mizuguchi H, Hayakawa T, Eguchi K, Niwa M 2002 A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J Immunol 168:2789-2794
16. Pichurin P, Yan XM, Farilla L, Guo J, Chazenbalk GD, Rapoport B, McLachlan SM 2001 Naked TSH receptor DNA vaccination: a Th1 T cell response in which intereron-γ production rather than antibody dominates the immune response in mice. Endocrinology 142:3530-3536
17. Rao PV, Watson PF, Weetman AP, Carayanniotis G, Banga JP 2003 Contrasting activities of thyrotropin receptor antibodies in experimental models of Graves' disease induced by injection of transfected fibroblasts or deoxyribo-nucleic acid vaccination. Endocrinology 144:260-266
18. Tahara K, Ban T, Minegishi T, Kohn LD 1991 Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CH receptor chimeras than either TSH or immunoglobulins from idiopathic myxoedema patients. Biochem Biophys Res Commun 179:70-77
19. Nagayama Y, Wadsworth HL, Russo D, Chazenbalk GD, Seto P, Rapoport B 1991 Thyrotropin-leuteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function. Proc Natl Acad Sci USA 88:902-905
20. Kikuoka S, Shimojo N, Yamaguchi K, Watanabe Y, Hoshioka A, Hirai A, Saito Y, Tahara K, Kohn LD, Maruyama N, Kohno Y, Niimi H 1998 The formation of thyrotropin receptor (TSHR) antibodies in a Graves' animal model requires the N-terminal segment of the TSHR extracellular domain. Endocrinology 139:1891-1898
21. Schwarz-Lauer L, Pichurin PN, Chen C, Nagayama Y, Paras C, Morris JC, Rapoport B, McLachlan SM 2003 The cysteine-rich amino terminus of the thyrotropin receptor is the immunodominant linear antibody epitope in mice immunized using naked deoxyribonucleic acid or adenovirus vectors. Endocrinology 144:1718-1725
22. Nagayama Y 1995 Continuous versus discontinuous B cell epitopes on thyrotropin receptor and thyroid peroxidase. Eur J Endocrinol 132:9-11
23. Costagliola S, Franssen JDF, Bonomi M, Urizar E, Willnich M, Bergmann A, Vassart G 2002 Generation of a mouse monoclonal TSH receptor antibody with stimulating activity. Biochem Biophys Res Commun 299:891-896
24. Morgenthaler NG 1999 New assay systems for thyrotropin receptor antibodies. Curr Opin Endocrinol Diabetes 6:251-260
25. Morris JC, Bergert ER, McCormick DJ 1993 Structure-function studies of the human thyrotropin receptor. Inhibition of binding of labeled thyrotropin (TSH) by synthetic human TSH receptor peptides. J Biol Chem 268:10900-10905
26. Nicholson LB, Vlase H, Graves P, Nilsson M, Molne J, Huang GC, Morgenthaler NG, Davies TF, McGregor AM, Banga JP 1996 Monoclonal antibodies to the human thyrotropin receptor: epitope mapping and binding to the native receptor on the basolateral plasma membrane of thyroid follicular cells. J Mol Endocrinol 16:159-170
27. Depaolo LV, Masoro EJ 1988 Endocrine hormones in laboratory animals. In: Loeb WF, Quimby FW, eds. Clinical chemistry of laboratory animals. Oxford, UK: Pergamon Press; 279-308
28. Schwarz-Lauer L, Chazenbalk GD, McLachlan SM, Ochi Y, Nagayama Y, Rapoport B 2002 Evidence for a simplified view of autoantibody interactions with the thyrotropin receptor. Thyroid 12:115-120
29. Grasso YZ, Kim MR, Faiman C, Kohn LD, Tahara K, Gupta MK 1999 Epitope heterogeneity of thyrotropin receptor-blocking antibodies in Graves' disease as detected with wild-type versus chimeric thyrotropin receptors. Thyroid 9:531-537
30. Chen CR, Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B 2001 A full biologicall response to autoantibodies in Graves' disease requires a disulphide-bond loop in the thyrotropin N terminus homologous to a laminin EGF-like domain. J Biol Chem 276:14767-14772