메뉴 건너뛰기




Volumn 139, Issue 4, 1998, Pages 1891-1898

The formation of thyrotropin receptor (TSHR) antibodies in a Graves' animal model requires the N-terminal segment of the TSHR extracellular domain

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; EPITOPE; LUTEINIZING HORMONE; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY;

EID: 7844233321     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.4.5876     Document Type: Article
Times cited : (31)

References (40)
  • 4
    • 0021245219 scopus 로고
    • Characterization of monoclonal antibodies derived from lymphocytes from Graves' disease patients in a cytochemical bioassay for thyroid stimulators
    • Ealey PA, Kohn LD, Ekins RP, Marshall NJ 1984 Characterization of monoclonal antibodies derived from lymphocytes from Graves' disease patients in a cytochemical bioassay for thyroid stimulators. J Clin Endocrinol Metab 58:909-914
    • (1984) J Clin Endocrinol Metab , vol.58 , pp. 909-914
    • Ealey, P.A.1    Kohn, L.D.2    Ekins, R.P.3    Marshall, N.J.4
  • 5
    • 0023116367 scopus 로고
    • Heterogeneity of Graves' immunoglobulin G: Comparison of thyrotropin receptor and antibodies in serum and in culture supernatants of lymphocytes transformed by Epstein-Barr virus infection
    • Yokoyama N, Izumi M, Katamine S, Nagataki S 1987 Heterogeneity of Graves' immunoglobulin G: comparison of thyrotropin receptor and antibodies in serum and in culture supernatants of lymphocytes transformed by Epstein-Barr virus infection. J Clin Endocrinol Metab 64:215-218
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 215-218
    • Yokoyama, N.1    Izumi, M.2    Katamine, S.3    Nagataki, S.4
  • 6
    • 0028950442 scopus 로고
    • Isolation of Epstein-Barr virus transformed lymphocytes producing IgG class monoclonal antibodies using a magnetic cell separator (MACS): Preparation of thyroid stimulating IgG antibodies from patients with Graves' disease
    • Li H, Akamizu T, Okuda J, Sugawa H, Matsuda F, Tsubata T, Mori T 1995 Isolation of Epstein-Barr virus transformed lymphocytes producing IgG class monoclonal antibodies using a magnetic cell separator (MACS): preparation of thyroid stimulating IgG antibodies from patients with Graves' disease. Biochem Biophys Res Commun 207:985-993
    • (1995) Biochem Biophys Res Commun , vol.207 , pp. 985-993
    • Li, H.1    Akamizu, T.2    Okuda, J.3    Sugawa, H.4    Matsuda, F.5    Tsubata, T.6    Mori, T.7
  • 7
    • 0029792876 scopus 로고    scopus 로고
    • Human immunoglobulin G autoantibodies to the thyrotropin receptor from Epstein-Barr Virus transformed B lymphocytes: Characterization by immunoprecipitation with recombinant antigen and biological activity
    • Morgenthaler NG, Kim MR, Tremble J, Huang GC, Richter W, Gupta M, Scherbaum WA, McGregor AM, Banga JP 1996 Human immunoglobulin G autoantibodies to the thyrotropin receptor from Epstein-Barr Virus transformed B lymphocytes: characterization by immunoprecipitation with recombinant antigen and biological activity. J Clin Endocrinol Metab 81:3155-3161
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3155-3161
    • Morgenthaler, N.G.1    Kim, M.R.2    Tremble, J.3    Huang, G.C.4    Richter, W.5    Gupta, M.6    Scherbaum, W.A.7    McGregor, A.M.8    Banga, J.P.9
  • 9
    • 0025831943 scopus 로고
    • Binding domains of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/chorionic gonadotropin receptors
    • Nagayama Y, Wadsworth HL, Russo D, Chazenbalk GD, Rapoport B 1991 Binding domains of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/chorionic gonadotropin receptors. J Clin Invest 88:336-340
    • (1991) J Clin Invest , vol.88 , pp. 336-340
    • Nagayama, Y.1    Wadsworth, H.L.2    Russo, D.3    Chazenbalk, G.D.4    Rapoport, B.5
  • 11
    • 0025951486 scopus 로고
    • Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or Immunoglobulins from idiopathic myxedema patients
    • Tahara K, Ban T, Minegishi T, Kohn LD 1991 Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or Immunoglobulins from idiopathic myxedema patients. Biochem Biophys Res Commun 179:70-77
    • (1991) Biochem Biophys Res Commun , vol.179 , pp. 70-77
    • Tahara, K.1    Ban, T.2    Minegishi, T.3    Kohn, L.D.4
  • 12
    • 0029937902 scopus 로고    scopus 로고
    • Epitopes for thyroid stimulating antibodies in Graves' sera: A possible link of heterogeneity to differences in response to antithyroid drug treatment
    • Kim WB, Cho BY, Park, HY, Lee HK, Kohn LD, Tahara K, Koh CS 1996 Epitopes for thyroid stimulating antibodies in Graves' sera: a possible link of heterogeneity to differences in response to antithyroid drug treatment. J Clin Endocrinol Metab 81:1758-1767
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1758-1767
    • Kim, W.B.1    Cho, B.Y.2    Park, H.Y.3    Lee, H.K.4    Kohn, L.D.5    Tahara, K.6    Koh, C.S.7
  • 13
    • 0031000765 scopus 로고    scopus 로고
    • Subtypes of anti-TSH receptor antibodies classified by bio- and conversion assays using CHO cells expressing wild type human TSH receptor or TSH receptor-LH/CG receptor chimera
    • Watanabe Y, Tahara K, Hirai A, Tada H, Kohn LD, Amino N 1997 Subtypes of anti-TSH receptor antibodies classified by bio- and conversion assays using CHO cells expressing wild type human TSH receptor or TSH receptor-LH/CG receptor chimera. Thyroid 7:13-20
    • (1997) Thyroid , vol.7 , pp. 13-20
    • Watanabe, Y.1    Tahara, K.2    Hirai, A.3    Tada, H.4    Kohn, L.D.5    Amino, N.6
  • 14
    • 0031154048 scopus 로고    scopus 로고
    • Changes in epitopes for thyroid stimulating antibodies in Graves' sera during treatment of hyperthyroidism: Therapeutic implications
    • Kim WB, Chung HK, Lee HK, Kohn LD, Tahara K, Cho BY 1997 Changes in epitopes for thyroid stimulating antibodies in Graves' sera during treatment of hyperthyroidism: therapeutic implications. J Clin Endocrinol Metab 82:1953-1988
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1953-1988
    • Kim, W.B.1    Chung, H.K.2    Lee, H.K.3    Kohn, L.D.4    Tahara, K.5    Cho, B.Y.6
  • 15
    • 0026522437 scopus 로고
    • Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid stimulating antibodies and with thyroid stimulating blocking antibodies in idiopathic myxedema: These determinants have no homologous sequence on gonadotropin receptors
    • Kosugi S, Ban T, Akamizu T, Kohn LD 1992 Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid stimulating antibodies and with thyroid stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors. Mol Endocrinol 6:168-180
    • (1992) Mol Endocrinol , vol.6 , pp. 168-180
    • Kosugi, S.1    Ban, T.2    Akamizu, T.3    Kohn, L.D.4
  • 16
    • 0027532027 scopus 로고
    • Identification of thyroid-stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor
    • Kosugi S, Ban T, Kohn LD 1993 Identification of thyroid-stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor. Mol Endocrinol 7:114-130
    • (1993) Mol Endocrinol , vol.7 , pp. 114-130
    • Kosugi, S.1    Ban, T.2    Kohn, L.D.3
  • 18
    • 0027325575 scopus 로고
    • Induction of TSH binding inhibitory immunoglobulins with the extracellular domain of human thyrotropin receptor produced using a baculovirus expression system
    • Seetharamaiah GS, Desai RK, Dallas JS, Tahara K, Kohn LD, Prabhakar BS 1993 Induction of TSH binding inhibitory immunoglobulins with the extracellular domain of human thyrotropin receptor produced using a baculovirus expression system. Autoimmunity 14:315-320
    • (1993) Autoimmunity , vol.14 , pp. 315-320
    • Seetharamaiah, G.S.1    Desai, R.K.2    Dallas, J.S.3    Tahara, K.4    Kohn, L.D.5    Prabhakar, B.S.6
  • 19
    • 0028059135 scopus 로고
    • Overexpression of the extracellular domain of the thyrotropin receptor in bacteria; production of thyrotropin binding inhibiting immunoglobulins
    • Costagliola S, Alcalde L, Ruf J, Vassart G, Ludgate M 1994 Overexpression of the extracellular domain of the thyrotropin receptor in bacteria; production of thyrotropin binding inhibiting immunoglobulins. J Mol Endocrinol 13:11-21
    • (1994) J Mol Endocrinol , vol.13 , pp. 11-21
    • Costagliola, S.1    Alcalde, L.2    Ruf, J.3    Vassart, G.4    Ludgate, M.5
  • 20
    • 0028300681 scopus 로고
    • Induction of thyrotropin receptor (TSH-R) autoantibodies and thyroiditis in mice immunized with the recombinant TSH-R
    • Costagliola S, Alcade L, Tonacchera M, Ruf J, Vassart G, Ludgate M 1994 Induction of thyrotropin receptor (TSH-R) autoantibodies and thyroiditis in mice immunized with the recombinant TSH-R. Biochem Biophys Res Commun 199:1027-1034
    • (1994) Biochem Biophys Res Commun , vol.199 , pp. 1027-1034
    • Costagliola, S.1    Alcade, L.2    Tonacchera, M.3    Ruf, J.4    Vassart, G.5    Ludgate, M.6
  • 21
    • 0028019518 scopus 로고
    • Recombinant thyrotropin receptor and the induction of autoimmune thyroid disease in BALB/c mice: A new animal model
    • Costagliola S, Many MC, Stalmans-Falys M, Tonacchera M, Vassart G, Ludgate M 1994 Recombinant thyrotropin receptor and the induction of autoimmune thyroid disease in BALB/c mice: a new animal model. Endocrinology 135:2150-2159
    • (1994) Endocrinology , vol.135 , pp. 2150-2159
    • Costagliola, S.1    Many, M.C.2    Stalmans-Falys, M.3    Tonacchera, M.4    Vassart, G.5    Ludgate, M.6
  • 22
    • 0028044013 scopus 로고
    • Induction of autoimmunity by immunization of mice with human thyrotropin receptor
    • Marion S, Braun JM, Ropars A, Kohn LD, Charreire J 1994 Induction of autoimmunity by immunization of mice with human thyrotropin receptor. Cell Immunol 158:329-341
    • (1994) Cell Immunol , vol.158 , pp. 329-341
    • Marion, S.1    Braun, J.M.2    Ropars, A.3    Kohn, L.D.4    Charreire, J.5
  • 24
    • 0028913483 scopus 로고
    • Unaltered thyroid function in mice responding to a highly immunogenic thyrotropin receptor: Implications for the establishment of a mouse model for Graves' disease
    • Carayanniotis G, Huang GC, Nicholson LB, Scott T, Allain F, McGregor AM, Banga JP 1995 Unaltered thyroid function in mice responding to a highly immunogenic thyrotropin receptor: implications for the establishment of a mouse model for Graves' disease. Clin Exp Immunol 99:294-302
    • (1995) Clin Exp Immunol , vol.99 , pp. 294-302
    • Carayanniotis, G.1    Huang, G.C.2    Nicholson, L.B.3    Scott, T.4    Allain, F.5    McGregor, A.M.6    Banga, J.P.7
  • 25
    • 0029054865 scopus 로고
    • Generation and characterization of monoclonal antibodies to the human thyrotropin (TSH) receptor: Antibodies can bind to discrete conformational or linear epitopes and block TSH binding
    • Seetharamaiah GS, Wagle NM, Morris JC, Prabhakar BS 1995 Generation and characterization of monoclonal antibodies to the human thyrotropin (TSH) receptor: antibodies can bind to discrete conformational or linear epitopes and block TSH binding. Endocrinology 136:2817-2824
    • (1995) Endocrinology , vol.136 , pp. 2817-2824
    • Seetharamaiah, G.S.1    Wagle, N.M.2    Morris, J.C.3    Prabhakar, B.S.4
  • 27
    • 0029093756 scopus 로고
    • Defining the major antibody epitopes on the human thyrotropin receptor in immunized mice: Evidence for intramolecular epitope spreading
    • Vlase H, Nakashima M, Graves PN, Tomer Y, Morris JC, Davies TF 1995 Defining the major antibody epitopes on the human thyrotropin receptor in immunized mice: evidence for intramolecular epitope spreading. Endocrinology 136:4415-4423
    • (1995) Endocrinology , vol.136 , pp. 4415-4423
    • Vlase, H.1    Nakashima, M.2    Graves, P.N.3    Tomer, Y.4    Morris, J.C.5    Davies, T.F.6
  • 30
    • 0027451585 scopus 로고
    • Dual mechanism of perturbation of thyrotropin mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR derived peptides
    • Desai RK, Dallas JS, Gupta MK, Seetharamaiah GS, Fan JL, Tahara K, Kohn LD, Prabhakar BS 1993 Dual mechanism of perturbation of thyrotropin mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR derived peptides. J Clin Endocrinol Metab 77:658-663
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 658-663
    • Desai, R.K.1    Dallas, J.S.2    Gupta, M.K.3    Seetharamaiah, G.S.4    Fan, J.L.5    Tahara, K.6    Kohn, L.D.7    Prabhakar, B.S.8
  • 31
    • 0026591115 scopus 로고
    • Biological activities of rabbit antibodies against synthetic human thyrotropin receptor peptides representing thyrotropin binding regions
    • Sakata S, Ogawa T, Matsui I, Manshouri T, Atassi MZ 1992 Biological activities of rabbit antibodies against synthetic human thyrotropin receptor peptides representing thyrotropin binding regions. Biochem Biophys Res Commun 182:1369-1375
    • (1992) Biochem Biophys Res Commun , vol.182 , pp. 1369-1375
    • Sakata, S.1    Ogawa, T.2    Matsui, I.3    Manshouri, T.4    Atassi, M.Z.5
  • 32
    • 0026074817 scopus 로고
    • Development of chicken antibodies toward the human thyrotropin receptor peptides and their bioactivities
    • Ohmori M, Endo T, Onaya T 1991 Development of chicken antibodies toward the human thyrotropin receptor peptides and their bioactivities. Biochem Biophys Res Commun 174:399-403
    • (1991) Biochem Biophys Res Commun , vol.174 , pp. 399-403
    • Ohmori, M.1    Endo, T.2    Onaya, T.3
  • 33
    • 0029896189 scopus 로고    scopus 로고
    • Thyrotropin (TSH) receptor antibodies (TSHRAb) can inhibit TSH-mediated cyclic adenosine 3′,5′-monophosphate production in thyroid cells by either blocking TSH binding or affecting a step subsequent to TSH binding
    • Dallas JS, Cunningham SJ, Patibandla SA, Seetharamaiah GS, Morris JC, Tahara K, Kohn LD, Prabhakar BS 1996 Thyrotropin (TSH) receptor antibodies (TSHRAb) can inhibit TSH-mediated cyclic adenosine 3′,5′-monophosphate production in thyroid cells by either blocking TSH binding or affecting a step subsequent to TSH binding. Endocrinology 137:3329-3339
    • (1996) Endocrinology , vol.137 , pp. 3329-3339
    • Dallas, J.S.1    Cunningham, S.J.2    Patibandla, S.A.3    Seetharamaiah, G.S.4    Morris, J.C.5    Tahara, K.6    Kohn, L.D.7    Prabhakar, B.S.8
  • 34
    • 0025744123 scopus 로고
    • A synthetic oligopeptide derived from the human thyrotropin receptor sequence binds to Graves' immunoglobulin and inhibits thyroid stimulating antibody activity but lacks interactions with TSH
    • Mori T, Sugawa H, Piraphatdist T, Inoue D, Enomoto T, Imura H 1991 A synthetic oligopeptide derived from the human thyrotropin receptor sequence binds to Graves' immunoglobulin and inhibits thyroid stimulating antibody activity but lacks interactions with TSH. Biochem Biophys Res Commun 178:165-172
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 165-172
    • Mori, T.1    Sugawa, H.2    Piraphatdist, T.3    Inoue, D.4    Enomoto, T.5    Imura, H.6
  • 35
    • 0028961403 scopus 로고
    • Thyroid stimulating antibodies in sera from patients with Graves' disease are heterogeneous in epitope recognition
    • Ueda Y, Sugawa H, Akamizu T, Okuda J, Ueda M, Kosugi S, Ohta C, Kihou Y, Mori T 1995 Thyroid stimulating antibodies in sera from patients with Graves' disease are heterogeneous in epitope recognition. Eur J Endocrinol 132:62-68
    • (1995) Eur J Endocrinol , vol.132 , pp. 62-68
    • Ueda, Y.1    Sugawa, H.2    Akamizu, T.3    Okuda, J.4    Ueda, M.5    Kosugi, S.6    Ohta, C.7    Kihou, Y.8    Mori, T.9
  • 36
    • 0028071359 scopus 로고
    • Identification of epitopes and affinity purification of thyroid stimulating autoantibodies using synthetic human TSHR peptides
    • Morris JC, Gibson JL, Haas EJ, Bergert ER, Dallas JS, Prabhakar BS 1994 Identification of epitopes and affinity purification of thyroid stimulating autoantibodies using synthetic human TSHR peptides. Autoimmunity 17:287-299
    • (1994) Autoimmunity , vol.17 , pp. 287-299
    • Morris, J.C.1    Gibson, J.L.2    Haas, E.J.3    Bergert, E.R.4    Dallas, J.S.5    Prabhakar, B.S.6
  • 37
    • 0026357029 scopus 로고
    • Role of N-terminal region of the thyrotropin (TSH) receptor in signal transduction for TSH or thyroid stimulating antibody
    • Ohmori M, Endo T, Ikeda M, Onaya T 1991 Role of N-terminal region of the thyrotropin (TSH) receptor in signal transduction for TSH or thyroid stimulating antibody. Biochem Biophys Res Commun 178:733-738
    • (1991) Biochem Biophys Res Commun , vol.178 , pp. 733-738
    • Ohmori, M.1    Endo, T.2    Ikeda, M.3    Onaya, T.4
  • 38
    • 0031158896 scopus 로고    scopus 로고
    • Thyrotropin receptor autoantibodies in serum are present at much lower levels than thyroid peroxidase autoantibodies: Analysis by flow cytometry
    • Jaume JC, Kakinuma A, Chazenbalk GD, Rapoport B, McLachlan SM 1997 Thyrotropin receptor autoantibodies in serum are present at much lower levels than thyroid peroxidase autoantibodies: analysis by flow cytometry. J Clin Endocrinol Metab 82:1885-1893
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1885-1893
    • Jaume, J.C.1    Kakinuma, A.2    Chazenbalk, G.D.3    Rapoport, B.4    McLachlan, S.M.5
  • 40
    • 0343297368 scopus 로고
    • Determinant spreading shown by monoclonal thyroid stimulating antibody produced against a TSH receptor peptide
    • Sugawa H, Ueda Y, Zhang M, Kosugi S, Ueda M, Mori T 1995 Determinant spreading shown by monoclonal thyroid stimulating antibody produced against a TSH receptor peptide. Thyroid [Suppl 1]5:S5
    • (1995) Thyroid [Suppl 1] , vol.5
    • Sugawa, H.1    Ueda, Y.2    Zhang, M.3    Kosugi, S.4    Ueda, M.5    Mori, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.