Crystal structure of RlmAI: Implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 12, 2004, Pages 4041-4046

  Das, Kalyan ^a,b   Acton, Thomas ^a,b   Chiang, Yiwen ^a,b   Shih, Lydia ^a,b   Arnold, Eddy ^a,b   Montelione, Gaetano T ^a,b,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Antibiotic resistance; Methyltransferase; RNA binding protein; rrmA

Indexed keywords

BACTERIAL ENZYME; DIMER; GUANINE; MACROLIDE; PROTEIN RIMA; RNA 23S; RNA BINDING PROTEIN; RNA METHYLTRANSFERASE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG; METHYLTRANSFERASE; ZINC;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING SITE; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA BINDING; RNA METHYLATION; RNA STRUCTURE; BINDING SITE; CHEMISTRY; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; MACROLIDES; METHYLTRANSFERASES; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RNA, RIBOSOMAL, 23S; S-ADENOSYLMETHIONINE; ZINC;

EID: 1642529580     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0400189101     Document Type: Article

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