Tissue-Specific Regulation of 4E-BP1 and S6K1 Phosphorylation by α-Ketoisocaproate

Journal of Nutritional Science and Vitaminology

Volumn 50, Issue 1, 2004, Pages 56-60

  Yoshizawa, Fumiaki ^a   Sekizawa, Haruhito ^a   Hirayama, Sachiyo ^a   Yamazaki, Yasuhiro ^a   Nagasawa, Takashi ^b   Sugahara, Kunio ^a  

^a UTSUNOMIYA UNIVERSITY   (Japan)

^b IWATE UNIVERSITY   (Japan)

Author keywords

4E BP1; Leucine; S6K1; Translation initiation; ketoisocaproate

Indexed keywords

2 OXOISOCAPROIC ACID; BINDING PROTEIN; BRANCHED CHAIN AMINO ACID; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; LEUCINE; MESSENGER RNA; REPRESSOR PROTEIN; RIBOSOME PROTEIN; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHIRALITY; CONTROLLED STUDY; DIETARY INTAKE; ENANTIOMER; IMMUNOHISTOCHEMISTRY; LIVER; MALE; METABOLITE; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; RNA TRANSLATION; SKELETAL MUSCLE; STEREOSPECIFICITY; TISSUE SPECIFICITY; TRANSLATION INITIATION; TRANSLATION REGULATION;

ANIMALIA; EUKARYOTA;

EID: 1642503830     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.50.56     Document Type: Article

References (26)

1. Yoshizawa F, Kimball SR, Jefferson LS. 1997. Modulation of translation initiation in rat skeletal muscle and liver in response to food intake. Biochem Biophys Res Commun 240: 825-831.
2. Anthony JC, Anthony TG, Kimball SR, Vary TC, Jefferson LS. 2000. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J Nutr 130: 139-145.
3. Yoshizawa F, Kimball SR, Vary TC, Jefferson LS. 1998. Effect of dietary protein on translation initiation in rat skeletal muscle and liver. Am J Physiol 275: E814-820.
4. Buse MG, Reid SS. 1975. Leucine. A possible regulator of protein turnover in muscle. J Clin Invest 56: 1250-1261.
5. Li JB, Jefferson LS. 1978. Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochim Biophys Acta 544: 351-359.
6. Buse MG. 1981. In vivo effects of branched chain amino acids on muscle protein synthesis in fasted rats. Horm Metab Res 13: 502-505.
7. Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR. 2000. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 130: 2413-2419.
8. Raught B, Gingras A-C, Sonenberg N. 2000. Regulation of ribosomal recruitment in eukaryotes. In: Translational Control of Gene Expression (Sonenberg N, Hershey JWB, Mathews MB, eds), p 245-293. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
9. Ptushkina M, von der Haar T, Karim MM, Hughes JMX, McCarthy JEG. 1999. Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state. EMBO J 18: 4068-4075.
10. Fumagalli S, Thomas G. 2000. S6 phosphorylation and signal transduction. In: Translational Control of Gene Expression (Sonenberg N, Hershey JWB, Mathews MB, eds), p 695-717. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
11. Anthony JC, Anthony TG, Kimball SR, Jefferson LS. 2001. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr 131: 856S-860S.
12. Yoshizawa F, Sekizawa H, Hirayama S, Hatakeyama A, Nagasawa T, Sugahara K. 2001. Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats. J Nutr Sci Vitaminol 47: 311-315.
13. Reeves PG, Nielsen FH, Fahey GC Jr. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123: 1939-1951.
14. Kimball SR, Jurasinski CV, Lawrence JC, Jefferson LS. 1997. Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G. Am J Physiol 272: C754-759.
15. Kimball SR, Horetsky RL, Jefferson LS. 1998. Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts. Am J Physiol 274: C221-228.
16. Harper AE, Miller RH, Block KP. 1984. Branched-chain amino acid metabolism. Annu Rev Nutr 4: 409-454.
17. Weng QP, Andrabi K, Kozlowski MT, Grove JR, Avruch J. 1995. Multiple independent inputs are required for activation of the p70 S6 kinase. Mol Cell Biol 15: 2333-2340.
18. Hasegawa H, Matsukawa T, Shinohara Y, Hashimoto T. 2000. Assessment of the metabolic chiral inversion of D-leucine in rat by gas chromatography-mass spectrometry combined with a stable isotope dilution analysis. Drug Metab Dispos 28: 920-924.
19. Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR. 1998. Bidirectional modulation of insulin action by amino acids. J Clin Invest 101: 1519-1529.
20. Xu G, Kwon G, Marshall CA, Lin TA, Lawrence JC Jr, McDaniel ML. 1998. Branched-chain amino acids are essential in the regulation of PHAS-1 and p70 S6 kinase by pancreatic β-cells. A possible role in protein translation and mitogenic signaling. J Biol Chem 273: 28178-28184.
21. Fox HL, Pham PT, Kimball SR, Jefferson LS, Lynch CJ. 1998. Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes. Am J Physiol 275: C1232-1238.
22. Goodwin GW, Zhang B, Paxton R, Harris RA. 1988. Determination of activity and activity state of branched-chain α-keto acid dehydrogenase in rat tissues. Methods Enzymol 166: 189-201.
23. Kobayashi R, Shimomura Y, Murakami T, Nakai N, Otsuka M, Arakawa N, Shimizu K, Harris RA. 1999. Hepatic branched-chain α-keto acid dehydrogenase complex in female rats: activation by exercise and starvation. J Nutr Sci Vitaminol 45: 303-309.
24. Shimomura Y, Nanaumi N, Suzuki M, Popov KM, Harris RA. 1990. Purification and partial characterization of branched-chain α-ketoacid dehydrogenase kinase from rat liver and rat heart. Arch Biochem Biophys 283: 293-299.
25. Popov KM, Zhao Y, Shimomura Y, Kuntz MJ, Harris RA. 1992. Branched-chain α-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases. J Biol Chem 267: 13127-13130.
26. Paxton R, Harris RA. 1984. Regulation of branched-chain α-ketoacid dehydrogenase kinase. Arch Biochem Biophys 231: 48-57.