Jud Coon: 35 Years of P450 research, a synopsis of P450 history

Drug Metabolism and Disposition

Volumn 32, Issue 1, 2004, Pages 1-6

  Porter, Todd D ^a  

^a University of Kentucky   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ALCOHOL; CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 2B4; CYTOCHROME P450 2E1; FATTY ACID; IRON DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; CATALYSIS; ENZYME ANALYSIS; ESCHERICHIA COLI; HUMAN; HYDROPHOBICITY; HYDROXYLATION; LIVER MICROSOME; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESEARCH; SHORT SURVEY;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FATTY ACIDS; HISTORY, 20TH CENTURY; HUMANS; IRON COMPOUNDS; ISOENZYMES; MICROSOMES, LIVER; MUTAGENESIS; MUTATION; NADPH-FERRIHEMOPROTEIN REDUCTASE;

ESCHERICHIA COLI;

EID: 1642498334     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.1.1     Document Type: Short Survey

References (58)

1. Barnes HJ, Arlotto MP, and Waterman MR (1991) Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli. Proc Notl Acad Sci USA 88:5597-5601.
2. Cederbaum AI, Wu D, Mari M, and Bai J (2001) CYP2EI-dependent toxicity and oxidative stress in HepG2 cells. Free Radic Biol Med 31:1539-1543.
3. Conney AH (2003) Induction of drug-metabolizing enzymes: a path to the discovery of multiple cytochromes P450. Annu Rev Pharmacol Toxicol 43:1-30.
4. Coon MJ (2002) Enzyme ingenuity in biological oxidations: a trail leading to cytochrome P450. J Biol Chem 277:28351-28363.
5. Coon MJ and Koop DR (1987) Alcohol-inducible cytochrome P-450 (P-450ALC). Arch Toxicol 60:16-21.
6. Coon MJ, Strobel HW, and Boyer RF (1973) On the mechanism of hydroxylation reactions catalyzed by cytochrome P-450. Drug Metab Dispos 1:92-97.
7. Coon MJ, Vaz AD, McGinnity DF, and Peng HM (1998) Multiple activated oxygen species in P450 catalysis: contributions to specificity in drug metabolism. Drug Metab Dispos 26:1190-1193.
8. Cooper DY (1973) Discovery of the function of the heme protein P-450: a systematic approach to scientific research. Life Sci 13:1151-1161.
9. Cooper DY, Levin S, Narasimhulu S, Rosenthal O, and Estabrook RW (1965) Photochemical action spectrum of the terminal oxidase of mixed function oxidase systems. Science (Wash DC) 147:400-402.
10. Cosme J and Johnson EF (2000) Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis and membrane binding. J Biol Chem 275:2545-2553.
11. Dignam JD and Strobel HW (1975) Preparation of homogeneous NADPH-cytochrome P-450 reductase from rat liver. Biochem Biophys Res Commun 63:845-852.
12. Estabrook RW, Hildebrandt AG, Baron J, Netter KJ, and Leibman K (1971) A new spectral intermediate associated with cytochrome P-450 function in liver microsomes. Biochem Biophys Res Commun 42:132-139.
13. Estabrook RW, Matsubara T, Mason JI, Werringloer J, and Baron J (1973) Studies on the molecular function of cytochrome P-450 during drug metabolism. Drug Metab Dispos 1:98-110.
14. Fujii-Kuriyama Y, Mizukami Y, Kawajiri K, Sogawa K, and Muramatsu M (1982) Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver. Proc Natl Acad Sci USA 79:2793-2797.
15. Fujii-Kuriyama Y, Taniguchi T, Mizukami Y, Sakai M, Tashiro Y, and Muramatsu M (1981) Construction and identification of a hybrid plasmid containing DNA sequence complementary to phenobarbital-inducible cytochrome P-450 messenger RNA from rat liver. J Biochem (Tokyo) 89:1869-1879.
16. Fujita VS, Thiele DJ, and Coon MJ (1990) Expression of alcohol-inducible rabbit liver cytochrome P-450 3a (P-450IIE1) in Saccharomyces cerevisiae with the copper-inducible CUP1 promoter. DNA Cell Biol 9:111-118.
17. Garfinkel D (1958) Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions. Arch Biochem Biophys 77:493-509.
18. Gutierrez A, Grunau A, Paine M, Munro AW, Wolf CR, Roberts GC, and Scrutton NS (2003) Electron transfer in human cytochrome P450 reductase. Biochem Soc Trans 31:497-501.
19. Haugen DA and Coon MJ (1976) Properties of electrophoretically homogeneous phenobarbital-inducible and β-naphthoflavone-inducible forms of liver microsomal cytochrome P-450. J Biol Chem 251:7929-7939.
20. Haugen DA, van der Hoeven TA, and Coon MJ (1975) Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms. J Biol Chem 250:3567-3570.
21. Horecker BL (1950) Triphosphopyridine nucleotide-cytochrome c reductase in liver. J Biol Chem 183:593-605.
22. Imai Y and Sato R (1966) Evidence for two forms of P-450 hemoprotein in microsomal membranes. Biochem Biophys Res Commun 23:5-11.
23. Imai Y and Sato R (1974) A gel-electrophoretically homogeneous preparation of cytochrome P-450 from liver microsomes of phenobarbital-pretreated rabbits. Biochem Biophys Res Commun 60:8-14.
24. Iyanagi T and Mason HS (1973) Some properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase. Biochemistry 12:2297-2308.
25. Kawalek JC, Levin W, Ryan D, Thomas PE, and Lu AY (1975) Purification of liver microsomal cytochrome P-448 from 3-methylcholanthrene-treated rabbits. Mol Pharmacol 11:874-878.
26. Khani SC, Porter TD, Fujita VS, and Coon MJ (1988) Organization and differential expression of two highly similar genes in the rabbit alcohol-inducible cytochrome P-450 subfamily. J Biol Chem 263:7170-7175.
27. Khani SC, Zaphiropoulos PG, Fujita VS, Porter TD, Koop DR, and Coon MJ (1987) cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a (P-450ALC). Proc Natl Acad Sci USA 84:638-642.
28. Klingenberg M (1958) Pigments of rat liver microsomes. Arch Biochem Biophys 75:376-386.
29. Klingenberg M (2003) The dragging emergence of the P450 cytochrome. Arch Biochem Biophys 412:2.
30. Koop DR and Coon MJ (1985) Role of alcohol P-450-oxygenase (APO) in microsomal ethanol oxidation. Alcohol 2:23-26.
31. Koop DR, Morgan ET, Tarr GE, and Coon MJ (1982) Purification and characterization of a unique isoenzyme of cytochrome-P-450 from liver-microsomes of ethanol-treated rabbits. J Biol Chem 257:8472-8480.
32. 2-terminal segment retains catalytic activity and is membrane-bound when expressed in Escherichia coli. J Biol Chem 266:7321-7324.
33. Lu AYH (1998) The 1996 Bernard B. Brodie Lecture: A journey in cytochrome P450 and drug metabolism research. Drug Metab Dispos 26:1168-1173.
34. Lu AYH and Coon MJ (1968) Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes. J Biol Chem 243:1331-1332.
35. Lu AYH, Junk KW, and Coon MS (1969) Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components. J Biol Chem 244:3714-3721.
36. Mannering GJ (2001) A life in science: biochemist-nutritionist-forensic toxicologst-pharmacologist. Drug Metab Rev 33:81-116.
37. Morgan ET, Koop DR, and Coon MJ (1982) Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols. J Biol Chem 257:13951-13957.
38. Murataliev MB and Feyereisen R (1999) Mechanism of cytochrome P450 reductase from the house fly: evidence for an FMN semiquinone as electron donor. FEBS Lett 453:201-204.
39. Nebert DW (1979) Multiple forms of inducible drug-metabolizing enzymes: a reasonable mechanism by which any organism can cope with adversity. Mol Cell Biochem 27:27-46.
40. Nebert DW, Adesnik M, Coon MJ, Estabrook RW, Gonzalez FJ, Guengerich FP, Gunsalus IC, Johnson EF, Kemper B, Levin W, et al. (1987) The P450 gene superfamily: recommended nomenclature. DNA 6:1-11.
41. Newcomb M, Hollenberg PF, and Coon MJ (2003) Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations. Arch Biochem Biophys 409:72-79.
42. Omura T and Sato R (1964a) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239:2370-2378.
43. Omura T and Sato R (1964b) The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification and properties. J Biol Chem 239:2379-2385.
44. Peng HM and Coon MJ (2000) Promoter function and the role of cytokines in the transcriptional regulation of rabbit CYP2E1 and CYP2E2. Arch Biochem Biophys 382:129-137.
45. Peterson JA, Basu D, and Coon MJ (1966) Enzymatic omega-oxidation. 1. Electron carriers in fatty acid and hydrocarbon hydroxylation. J Biol Chem 241:5162-5164.
46. Peterson JA and Coon MJ (1968) Enzymatic omega-oxidation. 3. Purification and properties of rubredoxin, a component of the omega-hydroxylation system of Pseudomonas oleovorans. J Biol Chem 243:329-334.
47. Porter TD, Khani SC, and Coon MJ (1989) Induction and tissue-specific expression of rabbit cytochrome P450IIE1 and IIE2 genes. Mol Pharmacol 36:61-65.
48. Poulos TL, Finzel BC, Gunsalus IC, Wagner GC, and Kraut J (1985) The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450. J Biol Chem 260:16122-16130.
49. Raag R, Martinis SA, Sligar SG, and Poulos TL (1991) Crystal-structure of the cytochrome-P-450cam active-site mutant Thr252ala. Biochemistry 30:11420-11429.
50. Sladek NE and Mannering GJ (1966) Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats. Biochem Biophys Res Commun 22:668-674.
51. Vaz AD, McGinnity DF, and Coon MJ (1998) Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant. Proc Natl Acad Sci USA 95:3555-3560.
52. Vermilion JL, Ballou DP, Massey V, and Coon MJ (1981) Separate roles for FMN and FAD in catalysis by liver microsomal NADPH-cytochrome P450 reductase. J Biol Chem 256:266-277.
53. Vermilion JL and Coon MJ (1978) Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states. J Biol Chem 253:2694-2704.
54. White RE and Coon MJ (1980) Oxygen activation by cytochrome P-450. Annu Rev Biochem 49:315-356.
55. White RE, Sligar SG, and Coon MJ (1980) Evidence for a homolytic mechanism of peroxide oxygen-oxygen bond cleavage during substrate hydroxylation by cytochrome P-450. J Biol Chem 255:11108-11111.
56. Williams CH Jr and Kamin H (1962) Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver. J Biol Chem 237:587-595.
57. Williams PA, Cosme J, Sridhar V, Johnson EF, and McRee DE (2000) Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity. Mol Cell 5:121-131.
58. Yasukochi Y and Masters BS (1976) Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography. J Biol Chem 251:5337-5344.