The cytotoxic potential of regulatory T cells: What has been learned from gene knockout model systems?

Transplantation

Volumn 77, Issue 1 SUPPL., 2004, Pages

  Marks, Lianne ^a   Levy, Robert B ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS LIGAND; INTERLEUKIN 2; PERFORIN;

ANIMAL CELL; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; GENE DISRUPTION; HOMEOSTASIS; IMMUNOREGULATION; KNOCKOUT GENE; KNOCKOUT MOUSE; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; ORGAN TRANSPLANTATION; PHENOTYPE; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE;

EID: 1642494604     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000106473.46037.83     Document Type: Conference Paper

References (13)

1. Surh CD, Sprent J. Homeostatic T cell proliferation: How far can T cells be activated to self-ligands? J Exp Med 2000; 192: F9.
2. Siegel RM, Fleisher TA. The role of Fas and related death receptors in autoimmune and other disease states. J Allergy Clin Immunol 1999; 103: 729.
3. Trimble LA, Prince KA, Pestano GA, et al. Fas-dependent elimination of nonselected CD8 cells and lpr disease. J Immunol 2002; 168: 4960.
4. Mountz JD, Zhou T, Eldridge J, et al. Transgenic rearranged T cell receptor gene inhibits lymphadenopathy and accumulation of CD4-CD8-B220+ T cells in lpr/lpr mice. J Exp Med 1990; 172: 1805.
5. Stepp SE, Dufourcq-Lagelouse R, Le Deist F, et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 1999; 286: 1957.
6. Jiang Z, Podack E, Levy RB. Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: Involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis. Blood 2001; 98: 390.
7. Marks L, Levy RB. Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GVHD in minor histocompatibility antigen mismatched BMT recipients. Transplantation 2004 (in press).
8. Almeida AR, Legrand N, Papiernik M, et al. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 2002; 169: 4850.
9. Suzuki H, Zhou YW, Kato M, et al. Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo. J Exp Med 1999; 190: 1561.
10. Waterhouse P, Bachmann MF, Penninger JM, et al. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice. Eur J Immunol 1997; 27: 1887.
11. Tivol EA, Gorski J. Re-establishing peripheral tolerance in the absence of CTLA-4: Complementation by wild-type T cells points to an indirect role for CTLA-4. J Immunol 2002; 169: 1852.
12. Bonfoco E, Stuart PM, Brunner T, et al. Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells. Immunity 1998; 9: 711.
13. Wolf M, Schimpl A, Hunig T. Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: Evidence for two distinct regulatory mechanisms. Eur J Immunol 2001; 31: 1637.