Generation of highly stable IL-18 based on a ligand-receptor complex structure

Biochemical and Biophysical Research Communications

Volumn 317, Issue 1, 2004, Pages 181-186

  Yamamoto, Yutaka ^a   Kato, Zenichiro ^a   Matsukuma, Eiji ^a   Li, Ailian ^a   Omoya, Kentaro ^a   Hashimoto, Kazuyuki ^a   Ohnishi, Hidenori ^a   Kondo, Naomi ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

3D structure; Cysteine; IL 18; Mutant; Stability

Indexed keywords

ANTINEOPLASTIC AGENT; CYSTEINE; CYTOKINE; LIGAND; RECOMBINANT INTERLEUKIN 18; SERINE;

ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG STABILITY; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TERTIARY STRUCTURE; RECEPTOR BINDING; RELIABILITY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CYSTEINE; DIMERIZATION; DRUG STABILITY; GENE EXPRESSION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-18; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-18; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

EID: 1642463477     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.03.024     Document Type: Article

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