-
1
-
-
0033574415
-
Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
-
Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. 1999. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. 274: 10689.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 10689
-
-
Chow, J.C.1
Young, D.W.2
Golenbock, D.T.3
Christ, W.J.4
Gusovsky, F.5
-
2
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in TLR4 gene
-
Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene. Science 282: 2085.
-
(1998)
Science
, vol.282
, pp. 2085
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.Y.4
Van Huffel, C.5
Du, X.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Galanos, C.10
Freudenberg, M.11
Ricciardi-Castagnoli, P.12
Layton, B.13
Beutler, B.14
-
3
-
-
0034084438
-
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
-
Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. 2000. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25: 187.
-
(2000)
Nat. Genet.
, vol.25
, pp. 187
-
-
Arbour, N.C.1
Lorenz, E.2
Schutte, B.C.3
Zabner, J.4
Kline, J.N.5
Jones, M.6
Frees, K.7
Watt, J.L.8
Schwartz, D.A.9
-
4
-
-
0037130195
-
Toll-like receptor 4 polymorphisms and atherogenesis
-
Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J, Schwartz DA. 2002. Toll-like receptor 4 polymorphisms and atherogenesis. New England J. Med. 347: 185.
-
(2002)
New England J. Med.
, vol.347
, pp. 185
-
-
Kiechl, S.1
Lorenz, E.2
Reindl, M.3
Wiedermann, C.J.4
Oberhollenzer, F.5
Bonora, E.6
Willeit, J.7
Schwartz, D.A.8
-
5
-
-
0037111078
-
Human Toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections
-
Agnese DM, Calvano JE, Hahm SJ, Coyle SM, Corbett SA, Calvano SE, Lowry SF. 2002. Human Toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J. Infect. Dis. 186: 1522.
-
(2002)
J. Infect. Dis.
, vol.186
, pp. 1522
-
-
Agnese, D.M.1
Calvano, J.E.2
Hahm, S.J.3
Coyle, S.M.4
Corbett, S.A.5
Calvano, S.E.6
Lowry, S.F.7
-
6
-
-
0037071251
-
Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
-
Lorenz E, Mira JP, Frees KL, Schwanz DA. 2002. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch. Intern. Med. 162: 1028.
-
(2002)
Arch. Intern. Med.
, vol.162
, pp. 1028
-
-
Lorenz, E.1
Mira, J.P.2
Frees, K.L.3
Schwanz, D.A.4
-
7
-
-
0037505640
-
Rapid and reliable genotyping for the Toll-like receptor 4 A896G polymorphism using fluorescence-labeled hybridization probes in a real-time polymerase chain reaction assay
-
Heesen M, Wessipe M, Kunz D, Vasickova K, Blomeke B. 2003. Rapid and reliable genotyping for the Toll-like receptor 4 A896G polymorphism using fluorescence-labeled hybridization probes in a real-time polymerase chain reaction assay. Clin. Chim. Acta 333: 47.
-
(2003)
Clin. Chim. Acta
, vol.333
, pp. 47
-
-
Heesen, M.1
Wessipe, M.2
Kunz, D.3
Vasickova, K.4
Blomeke, B.5
-
8
-
-
0035206253
-
Lack of association between the -260 C→T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels
-
Heesen M, Blomeke B, Schluter B, Heussen N, Rossaint R, Kunz D. 2001. Lack of association between the -260 C→T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels. Intensive Care Med. 27: 1770.
-
(2001)
Intensive Care Med.
, vol.27
, pp. 1770
-
-
Heesen, M.1
Blomeke, B.2
Schluter, B.3
Heussen, N.4
Rossaint, R.5
Kunz, D.6
-
9
-
-
0036185420
-
Can the interleukin-6 response to endotoxin be predicted? Studies of the influence of a promoter polymorphism of the interleukin-6 gene, gender, the density of the endotoxin receptor CD14, and inflammatory cytokines
-
Heesen M, Bloemeke B, Heussen N, Kunz D. 2002. Can the interleukin-6 response to endotoxin be predicted? Studies of the influence of a promoter polymorphism of the interleukin-6 gene, gender, the density of the endotoxin receptor CD14, and inflammatory cytokines. Crit. Care Med. 30: 664.
-
(2002)
Crit. Care Med.
, vol.30
, pp. 664
-
-
Heesen, M.1
Bloemeke, B.2
Heussen, N.3
Kunz, D.4
-
10
-
-
0036790341
-
Polymorphisms of TLR4: Rapid genotyping and reduced response to lipopolysaccharid- of TLR4 mutant alleles
-
Schmitt C, Humeny A, Becker C-M, Brune K, Pahl A. 2002. Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharid-of TLR4 mutant alleles. Clin. Chem. 48: 1661.
-
(2002)
Clin. Chem.
, vol.48
, pp. 1661
-
-
Schmitt, C.1
Humeny, A.2
Becker, C.-M.3
Brune, K.4
Pahl, A.5
-
11
-
-
0037247996
-
Linkage disequilibrium between tumor necrosis factor (TNF)-alpha-308 G/A promoter and TNF-beta NcoI polymorphisms: Association with TNF-alpha response of granulocytes to endotoxin stimulation
-
Heesen M, Kunz D, Bachmann-Mennenga B, Merk HF, Bloemeke B. 2003. Linkage disequilibrium between tumor necrosis factor (TNF)-alpha-308 G/A promoter and TNF-beta NcoI polymorphisms: Association with TNF-alpha response of granulocytes to endotoxin stimulation. Crit. Care Med. 31: 211.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 211
-
-
Heesen, M.1
Kunz, D.2
Bachmann-Mennenga, B.3
Merk, H.F.4
Bloemeke, B.5
-
12
-
-
0035991496
-
The CD 14-260 C→T promoter polymorphism co-segregates with the tumor necrosis factor-alpha (TNF-alpha)-308 G→A polymorphism and is associated with the interleukin-1 beta (IL-1 beta) synthesis capacity of human leukocytes
-
Heesen M, Bloemeke B, Bachmann-Mennenga B, Kunz D. 2002. The CD 14-260 C→T promoter polymorphism co-segregates with the tumor necrosis factor-alpha (TNF-alpha)-308 G→A polymorphism and is associated with the interleukin-1 beta (IL-1 beta) synthesis capacity of human leukocytes. Eur. Cytokine Netw. 13: 230.
-
(2002)
Eur. Cytokine Netw.
, vol.13
, pp. 230
-
-
Heesen, M.1
Bloemeke, B.2
Bachmann-Mennenga, B.3
Kunz, D.4
-
13
-
-
7344251714
-
Tumor necrosis factor (TNF) gene polymorphism influences TNF-α production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans
-
Louis E, Franchimont D, Piron A, Gevaert Y, Schaaf-Lafontaine N, Roland S, Mahieu P, Malaise M, De Groote D, Louis R, Belaiche J. 1998. Tumor necrosis factor (TNF) gene polymorphism influences TNF-α production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin. Exp. Immunol. 113: 401.
-
(1998)
Clin. Exp. Immunol.
, vol.113
, pp. 401
-
-
Louis, E.1
Franchimont, D.2
Piron, A.3
Gevaert, Y.4
Schaaf-Lafontaine, N.5
Roland, S.6
Mahieu, P.7
Malaise, M.8
De Groote, D.9
Louis, R.10
Belaiche, J.11
-
14
-
-
0033082245
-
Relation of ex vivo stimulated blood cytokine synthesis to post-traumatic sepsis
-
Flach R, Majetschak M, Heukamp T, Jennissen V, Flohe S, Boergermann J, Obertacke U, Schade FU. 1999. Relation of ex vivo stimulated blood cytokine synthesis to post-traumatic sepsis. Cytokine 11: 173.
-
(1999)
Cytokine
, vol.11
, pp. 173
-
-
Flach, R.1
Majetschak, M.2
Heukamp, T.3
Jennissen, V.4
Flohe, S.5
Boergermann, J.6
Obertacke, U.7
Schade, F.U.8
-
15
-
-
0031442798
-
Regulation of whole blood tumor necrosis factor production upon endotoxin stimulation after severe blunt trauma
-
Majetschak M, Flach R, Heukamp T, Jennissen V, Obertacke U, Neudeck F, Schmit-Neuerburg KP, Schade FU. 1997. Regulation of whole blood tumor necrosis factor production upon endotoxin stimulation after severe blunt trauma. J. Trauma 43: 880.
-
(1997)
J. Trauma
, vol.43
, pp. 880
-
-
Majetschak, M.1
Flach, R.2
Heukamp, T.3
Jennissen, V.4
Obertacke, U.5
Neudeck, F.6
Schmit-Neuerburg, K.P.7
Schade, F.U.8
-
16
-
-
0032931385
-
The extent of traumatic damage determines a graded depression of the endotoxin responsiveness of peripheral blood mononuclear cells from patients with blunt injuries
-
Majetschak M, Flach R, Kreuzfelder E, Jennissen V, Heukamp T, Neudeck F, Schmit-Neuerburg KP, Obertacke U, Schade FU. 1999. The extent of traumatic damage determines a graded depression of the endotoxin responsiveness of peripheral blood mononuclear cells from patients with blunt injuries. Crit. Care Med. 27: 313.
-
(1999)
Crit. Care Med.
, vol.27
, pp. 313
-
-
Majetschak, M.1
Flach, R.2
Kreuzfelder, E.3
Jennissen, V.4
Heukamp, T.5
Neudeck, F.6
Schmit-Neuerburg, K.P.7
Obertacke, U.8
Schade, F.U.9
-
17
-
-
0024814903
-
Interleukin-6: A multifunctional cytokine regulating immune reactions and the acute phase protein response
-
Le JM, Vilcek J. 1988. Interleukin-6: a multifunctional cytokine regulating immune reactions and the acute phase protein response. Lab. Invest. 61: 588.
-
(1988)
Lab. Invest.
, vol.61
, pp. 588
-
-
Le, J.M.1
Vilcek, J.2
-
18
-
-
0032189103
-
The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
-
Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P. 1998. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J. Clin. Invest. 102: 1369.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1369
-
-
Fishman, D.1
Faulds, G.2
Jeffery, R.3
Mohamed-Ali, V.4
Yudkin, J.S.5
Humphries, S.6
Woo, P.7
-
19
-
-
0040780540
-
Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation
-
Terry CF, Loukaci V, Green FR. 2000. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J. Biol. Chem. 275: 18138.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18138
-
-
Terry, C.F.1
Loukaci, V.2
Green, F.R.3
-
20
-
-
0028978849
-
Organization of the α-globin promoter and possible role of nuclear factor I in an α-globin inducible and a noninducible cell line
-
Rein TR, Forster A, Krause A, Winnacker EL, Zorbas H. 1995. Organization of the α-globin promoter and possible role of nuclear factor I in an α-globin inducible and a noninducible cell line. J. Biol. Chem. 270: 19643.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19643
-
-
Rein, T.R.1
Forster, A.2
Krause, A.3
Winnacker, E.L.4
Zorbas, H.5
-
21
-
-
0030891011
-
NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNa processing
-
Liu Y, Bernard HU, Apt D. 1997. NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing. J. Biol. Chem. 272: 10739.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10739
-
-
Liu, Y.1
Bernard, H.U.2
Apt, D.3
-
22
-
-
0023555768
-
Further developments of protein secondary structure prediction using information theory. New parameters and consideration of residue pairs
-
Gibrat JF, Garnier J, Robson B. 1987. Further developments of protein secondary structure prediction using information theory. New parameters and consideration of residue pairs. J. Mol. Biol. 198: 425.
-
(1987)
J. Mol. Biol.
, vol.198
, pp. 425
-
-
Gibrat, J.F.1
Garnier, J.2
Robson, B.3
-
23
-
-
0030862033
-
The -308 tumor necrosis factor-α promoter polymorphism effects transcription
-
Kroeger KM, Carville KS, Abraham LJ. 1997. The -308 tumor necrosis factor-α promoter polymorphism effects transcription. Mol. Immunol. 34: 391.
-
(1997)
Mol. Immunol.
, vol.34
, pp. 391
-
-
Kroeger, K.M.1
Carville, K.S.2
Abraham, L.J.3
-
24
-
-
0030954180
-
Effects of a polymorphism in the human tumor necrosis factor- A promoter on transcriptional activation
-
Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. 1997. Effects of a polymorphism in the human tumor necrosis factor-a promoter on transcriptional activation. Proc. Natl. Acad. Sci. USA 94: 3195.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3195
-
-
Wilson, A.G.1
Symons, J.A.2
McDowell, T.L.3
McDevitt, H.O.4
Duff, G.W.5
-
25
-
-
0032837736
-
A common functional polymorphism (C→A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha
-
Skoog T, van't Hooft FM, Kallin B, Jovinge S, Boquist S, Nilsson J, Eriksson P, Hamsten A. 1999. A common functional polymorphism (C→A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha. Hum. Mol. Genet. 8: 1443.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 1443
-
-
Skoog, T.1
Van't Hooft, F.M.2
Kallin, B.3
Jovinge, S.4
Boquist, S.5
Nilsson, J.6
Eriksson, P.7
Hamsten, A.8
-
26
-
-
0038202199
-
Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome
-
Child NJA, Yang IA, Pulletz MC, de Courcy-Golder K, Andrews AL, Pappachan VJ, Holloway JW. 2003. Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome. Biochem. Soc. Trans. 31: 652.
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 652
-
-
Child, N.J.A.1
Yang, I.A.2
Pulletz, M.C.3
De Courcy-Golder, K.4
Andrews, A.L.5
Pappachan, V.J.6
Holloway, J.W.7
-
27
-
-
0038466078
-
Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis
-
Feterowski C, Emmanuilidis K, Miethke T, Gerauer K, Rump M, Ulm K, Holzmann B, Weighardt H. 2003. Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis. Immunology 109: 426.
-
(2003)
Immunology
, vol.109
, pp. 426
-
-
Feterowski, C.1
Emmanuilidis, K.2
Miethke, T.3
Gerauer, K.4
Rump, M.5
Ulm, K.6
Holzmann, B.7
Weighardt, H.8
-
28
-
-
0037866985
-
Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling
-
Erridge C, Stewart J, Poxton IR. 2003. Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J. Exp. Med. 197: 1787.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1787
-
-
Erridge, C.1
Stewart, J.2
Poxton, I.R.3
-
29
-
-
0035676740
-
The role of TLR4 in endotoxin responsiveness in humans
-
Schwartz DA. 2001. The role of TLR4 in endotoxin responsiveness in humans. J. Endotoxin. Res. 7: 389.
-
(2001)
J. Endotoxin. Res.
, vol.7
, pp. 389
-
-
Schwartz, D.A.1
-
30
-
-
0035115080
-
Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages
-
Hirschfeld M, Weis JJ, Toshchakov V, Salkowski CA, Cody MJ, Ward DC, Qureshi N, Michalek SM, Vogel SN. 2001. Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect. Immun. 69: 1477.
-
(2001)
Infect. Immun.
, vol.69
, pp. 1477
-
-
Hirschfeld, M.1
Weis, J.J.2
Toshchakov, V.3
Salkowski, C.A.4
Cody, M.J.5
Ward, D.C.6
Qureshi, N.7
Michalek, S.M.8
Vogel, S.N.9
-
31
-
-
0034662239
-
Cutting edge: Repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2
-
Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ. 2000. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J. Immunol. 165: 618.
-
(2000)
J. Immunol.
, vol.165
, pp. 618
-
-
Hirschfeld, M.1
Ma, Y.2
Weis, J.H.3
Vogel, S.N.4
Weis, J.J.5
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