The CD14-260 C → T promoter polymorphism co-segregates with the tumor necrosis factor-α (TNF-α)-308 G → A polymorphism and is associated with the interleukin-1β (IL-1β) synthesis capacity of human leukocytes

European Cytokine Network

Volumn 13, Issue 2, 2002, Pages 230-233

  Heesen, Michael ^a   Bloemeke, Brunhilde ^a   Bachmann Mennenga, Bernd ^a   Kunz, Dagmar ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

CD14; Endotoxin; Genetic polymorphism; Interleukin 1 ; Linkage disequilibrium; Polymerase chain reaction; Tumor necrosis factor

Indexed keywords

ADENINE; CD14 ANTIGEN; CYTOSINE; ENDOTOXIN; GUANINE; INTERLEUKIN 1; INTERLEUKIN 1BETA; THYMINE; TUMOR NECROSIS FACTOR ALPHA; LIPOPOLYSACCHARIDE; PRIMER DNA;

ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; CYTOKINE RELEASE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; HOMOZYGOSITY; HUMAN; HUMAN EXPERIMENT; LEUKOCYTE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN SYNTHESIS; BLOOD; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; DNA PRIMERS; ENDOTOXINS; GENOTYPE; HUMAN; INTERLEUKIN-1; LEUKOCYTES; LIPOPOLYSACCHARIDES; POLYMORPHISM (GENETICS); PROMOTER REGIONS (GENETICS); TUMOR NECROSIS FACTOR; HUMANS; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035991496     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

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4. The -308 tumor necrosis factor-α promoter polymorphism effects transcription
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6. -308 Tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter
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13. Real-time PCR assay with fluorescent hybridization probes for the rapid genotyping of the CD14 promoter polymorphism
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19. The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors
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