Hematopoietic stem cell transplantation: More than just hematopoietic?

Journal of Cancer Research and Clinical Oncology

Volumn 130, Issue 3, 2004, Pages 127-134

  Spyridonidis, Alexandros ^a   Mertelsmann, Roland ^a   Finke, Jürgen ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Hematopoietic; Stem cell transplantation

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNITY; CELL DIFFERENTIATION; CELL FATE; CELL POPULATION; CHIMERA; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; KUPFFER CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; STEM CELL TRANSPLANTATION; TISSUE REGENERATION;

HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS;

EID: 1642340005     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-003-0507-x     Document Type: Review

References (80)

1. Abkowitz JL. Can human hematopoietic stem cells become skin, gut, or liver cells? N Engl J Med. 2002;346:770-2
2. Alison MR, Poulsom R, Jeffery R, et al. Hepatocytes from non-hepatic adult stem cells. Nature 2000;406:257
3. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M, Kearne M, Magner M, Isner JM. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res. 1999;85:221-8
4. Avital I, Inderbitzin D, Aoki T, Tyan DB, Cohen AH, Ferraresso C, Rozga J, Arnaout WS, Demetriou AA. Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells. Biochem Biophys Res Commun. 2001;288: 156-64
5. Bianchi DW, Zickwolf GK, Weil GJ, Sylvester S, DeMaria MA. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci U S A. 1996;93:705-8
6. Blau HM. A twist of fate. Nature. 2002;419:437
7. Blau, HM, Chiu, CP, and Webster, C. Cytoplasmic activation of human nuclear genes in stable heterokaryons. Cell 1983; 32:1171-1180
8. Borzillo GV, Ashmun RA, Sherr CJ. Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes.Mol Cell Biol. 1990;10:2703-14
9. Brazelton TR, Rossi FM, Keshet GI, Blau HM. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 2000;290:1775-9
10. Brockes JP. Amphibian limb regeneration: re-building a complex structure. Science. 1997;276:81-87
11. Byrne JA, Simonsson S, Western PS, Gurdon JB. Nuclei of Adult Mammalian Somatic Cells Are Directly Reprogrammed to oct-4 Stem Cell Gene Expression by Amphibian Oocytes. Current Biology, 2003;13:1206-1213
12. Choi J, Costa ML, Mermelstein CS, Chagas C, Holtzer S, Holtzer H. MyoD converts primary dermal fibroblasts, chondroblasts, smooth muscle, and retinal pigmented epithelial cells into striated mononucleated myoblasts and multinucleated myotubes. Proc Natl Acad Sci U S A. 1990;87: 7988-92
13. De Palma M, Venneri MA, Roca C, Naldini L. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat Med. 2003;9:789-95
14. Eglitis MA, Mezey E. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc. Natl. Acad. Sci. USA 94;4080-4085, 1997
15. Endler G, Greinix H, Winkler K, Mitterbauer G, Mannhalter C. Genetic fingerprinting in mouthwashes of patients after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1999;24:95-8
16. Feher et al. Alopecia Universalis Completely Resolved Following Autologous Bone Marrow Transplantation Arch Dermatol. 2002;138:1102-1103
17. Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F. Muscle regeneration by bone marrow derived myogenic progenitors. Science 1998;279:1528-1530
18. Gale RP, Sparkes RS, Golde DW. Bone marrow origin of hepatic macrophages (Kupffer cells) in humans. Science 1978;201:937-938
19. Geiger H, Sick S, Bonifer C, Müller AM. Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts. Cell. 1998;93:1055-1065
20. Graf T. Differentiation plasticity of hematopoietic cells. Blood 2002;99:3089-3101
21. Grant MB, May WS, Caballero S, Brown GA, Guthrie SM, Mames RN, Byrne BJ, Vaught T, Spoerri PE, Peck AB, Scott EW. Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization. Nat Med. 2002;8:607-12
22. Gunsilius E, Duba HC, Petzer AL, Kahler CM, Grunewald K, Stockhammer G, Gabi C, Dirnhofer S, Clausen J, Gastl G. Evidence from a leukaemia model for maintenance of vascular endothelium by bone-marrow-derived endothelial cells. Lancet 2000;355:1688-91
23. Gussoni E, Soneoka Y, Strickland CD et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 1999;401:390
24. Hess D, Li L, Martin M, Sakano S, Hill D, Strutt B, Thyssen S, Gray DA, Bhatia M. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol. 2003;21:763-770
25. Holden C, Vogel G. Stem cells. Plasticity: time for a reappraisal? Science. 2002;296:2126-9
26. Horwitz EM, Prockop DJ, Fitzpatrick LA et al. Transplantability and therapeutic effects of bone -marrow derived messenchymal cells in children with osteogenesis imperfecta. Nature Medicine 1999;5:309
27. Huss R, Lange C, Weissinger EM, Kolb HJ, Thalmeier K. Evidence of peripheral blood derived, plastic-adherent CD34(-/ low) hematopoietic stem cell clones with mesenchymal stem cell characteristics. Stem Cells 2000;18:252-60
28. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41-9
29. Jones DE. Fetal microchimerism: an aetiological factor in primary biliary cirrhosis? J Hepatol. 2000;33:834-7
30. Kleeberger W, Rothamel T, Glockner S, Flemming P, Lehmann U, Kreipe H. High frequency of epithelial chimerism in liver transplants demonstrated by microdissection and STRanalysis. Hepatology 2002;35:110-6
31. Kleeberger W, Versmold A, Rothamel T, Glockner S, Bredt M, Haverich A, Lehmann U, Kreipe H. Increased chimerism of bronchial and alveolar epithelium in human lungallografts undergoing chronic injury. Am J Pathol. 2003;162:1487-94
32. Kocher AA, Schuster MD, Szaboles MJ et al. Neovascularization of ischemic myocardium by human bone-marrow derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nature Medicine 2001; 7:430
33. Kondo T, Raff M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science. 2000;289:1754-1757
34. Körbling M, Katz RL, Khanna A, et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med 2002;346:738-746
35. Kotton DN, Ma BY, Cardoso WV, et al. Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development 2001;128:5181-5188
36. Krause DS, Theise ND, Colector MI, et al. Multi-organ, multilineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-377
37. Kreisel W, Potthoff K, Bertz H, Schmitt-Graeff A, Ruf G, Rasenack J, Finke J. Complete remission of Crohn's disease after high-dose cyclophosphamide and autologous stem cell transplantation. Bone Marrow Transplant. 2003;32:337-40
38. Lagasse E, Connors H, Al-Dhalimy M, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nature Med 2000;6:1229-1234
39. Lee TH, Paglieroni T, Ohto H, Holland PV, Busch MP. Survival of donor leukocyte subpopulations in immunocompetent transfusion recipients: frequent long-term microchimerism in severe trauma patients. Blood. 1999;93:3127-39
40. Liechty K, MacKenzie T, Shaaban A, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nature Med 2000; 6:1282-1286
41. Lindeman GJ, Adams JM, Cory S, Harris AW. B-lymphoid to granulocytic switch during hematopoiesis in a transgenic mousestrain. Immunity. 1994;1:517-27
42. Lyden D, Hattori K, Dias S, et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med. 2001;7:1194-201
43. Mathieu C, Bouillon R, Rutgeerts O, Waer M. Induction of mixed bone marrow chimerism as potential therapy for autoimmune (type I) diabetes: experience in the NOD model. Transplant Proc 1995;27:640-641
44. McGann CJ, Odelberg SJ, Keating MT. Mammalian myotube dedifferentiation induced by newt regeneration extract. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13699-704
45. Mezey E, Chandross KJ, Harta G, et al. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000;290:1779-82
46. Montecino-Rodriguez E, Leathers H, Dorshkind K. Bipotential B-macrophage progenitors are present in adult bone marrow. Nat Immunol. 2001;2:83-8
47. Moolten FL, Bucher NL. Regeneration of rat liver: transfer of humoral agent by cross circulation. Science. 1967 Oct 13;158:272-4
48. Nelson JL. Microchimerism and scleroderma. Curr Rheumatol Rep. 1999;1:15-21
49. Newmark PA, Sanchez Alvarado A. Not your father's planarian: a classic model enters the era of functional genomics.Nat Rev Genet. 2002;3:210-9
50. Odelberg SJ, Kollhoff A, Keating MT. Dedifferentiation of mammalian myotubes induced by msx1. Cell. 2000;103:1099-109
51. Okamoto R, Yajima T, Yamazaki M, Kanai T, Mukai M, Okamoto S, Ikeda Y, Hibi T, Inazawa J, Watanabe M. Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat Med. 2002;8:1011-7
52. Orlic D, Kajstura J, Chimenti S et al. Bone marrow cells regenerate ifarcted myocardium. Nature 2001;410:701
53. Pereira R, O'Hara M, Laptev A, et al. Marrow stromal cells, a source of progenitor cells for nonhematopoietic tissues in transgeneic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci U S A 1998;95:1142-1147
54. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS, Goff JP. Bone Marrow as a Potential Source of Hepatic Oval Cells. Science 1999; 284:1168-1170
55. Poulsom R, Forbes SJ, Hodivala-Dilke K, Ryan E, Wyles S, Navaratnarasah S, Jeffery R, Hunt T, Alison M, Cook T, Pusey C, Wright NA. Bone marrow contributes to renal parenchymal turnover and regeneration. Pathol 2001;195:229-35
56. Quesenberry PJ, Colvin GA, Lambert JF. The chiaroscuro stem cell: a unified stem cell theory. Blood. 2002;100:4266-71
57. Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med. 2003;9:702-12
58. Shen CN, Slack JM, Tosh D. Molecular basis of transdifferentiation of pancreas to liver. Nat Cell Biol. 2000;2:879-87
59. Shi Q, Rafii S, Wu MH, Wijelath ES, Yu C, Ishida A, Fujita Y, Kothari S, Mohle R, Sauvage LR, Moore MA, Storb RF, Hammond WP. Evidence for circulating bone marrow-derived endothelial cells. Blood. 1998;92:362-7
60. Smallcombe A. Multicolor Imaging: The important Question of Co-localization. BioTechniques 2001;30:1240-1246
61. Specs JL, Olson SD, Ylostalo J, Lynch PJ, Smith J, Perry A, Peister A, Wang MY, Prockop DJ. Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc Natl Acad Sci U S A. 2003;100:2397-402
62. Spradling A, Drummond-Barbosa D, Kai T. Stem cells find their niche. Nature. 2001 Nov 1;414(6859):98-104
63. Spyridonidis A, Schmitt-Gräff A, Tomann T, Dwenger A, Follo M, Behringer D, Finke J. Chimeric status of gut epithelium after human hematopoietic stem cell transplantation. Am J Pathol (in press)
64. Srivatsa B, Srivatsa S, Johnson KL, Samura O, Lee SL, Bianchi DW. Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study. Lancet. 2001;358:2034-8
65. Suratt BT, Cool CD, Serls AE, Chen L, Varella-Garcia M, Shpall EJ, Brown KK, Worthen GS. Human Pulmonary Chimerism Following Hematopoietic Stem Cell transplantation. Am J Respir Crit Care Med. 2003, doi:10.1164/rccm.200301-145OC
66. Terada N, Hamazaki T, Oka M, et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002;416:542-545
67. Theise ND, Badve S, Saxena R, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 2000a;31:235-240
68. Theise ND, Nimmakayalu M, Gardner R, et al. Liver from bone marrow in humans. Hepatology 2000b;32:11-16
69. Theise ND, Henegariu O, Grove J, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow. Exp Hematol. 2002;30:1333-8
70. Tran S, Pillemer SR, Dutra A, et al. Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study. Lancet 2003, 361:1084-1088
71. Unger ER, Sung JH, Manivel JC, Chenggis ML, Blazar BR, Krivit W. Male donor-derived cells in the brains of female sex-mismatched bone marrow transplant recipients: a Y chromosome specific in situ hybridization study. J Neuropath Exp Neurol 1993;42:460
72. Vassilopoulos G, Wang P, Russell DW. Transplanted bone marrow regenerates liver by cell fusion. Nature, 2003;422:901-4
73. Volc-Platzer B, Stingl G, Wolff K, Hinterberg W, Schnedl W. Cytogenetic identification of allogeneic epidermal Langerhans cells in a bone marrow graft recipient. N Engl J Med 1984;310:1123-1124
74. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science. 2002;297:2256-9
75. Wang X, Montini E, Al-Dhalimy M, Lagasse E, Finegold M, Grompe M. Kinetics of liver repopulation after bone marrow transplantation. Am J Pathol. 2002;161:565-74
76. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M. Cell fusion is the principal source of bone-marrow derived hepatocytes. Nature, 2003, 422:897-901
77. Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature. 1997;385:810-3
78. Xie T, Spradling AC. A niche maintaining germ line stem cells in the Drosophila ovary. Science. 2000 Oct 13;290(5490): 328-30
79. Ying QL, Nichols J, Evans EP, Smith AG. Changing potency by spontaneous fusion. Nature 2002;416:545-548
80. Zvaifler NJ, Marinova-Mutafchieva L, Adams G, Edwards CJ, Moss J, Burger JA, Maini RN. Mesenchymal precursor cells in the blood of normal individuals. Arthritis Res 2000; 2:477-88