No α-adrenoreceptor-induced C-fiber activation in healthy human skin

Journal of Applied Physiology

Volumn 96, Issue 4, 2004, Pages 1380-1384

  Zahn, Sebastian ^b   Leis, Stefan ^b   Schick, Christoph ^b   Schmelz, Martin ^b   Birklein, Frank ^a,c  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Axon reflex; Laser Doppler imaging; Sympathetic nervous system

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; CLONIDINE; NORADRENALIN; PHENYLEPHRINE;

ADULT; ARTICLE; AXON REFLEX; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; HUMAN EXPERIMENT; IONTOPHORESIS; LASER DOPPLER FLOWMETRY; MALE; MICRODIALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; REFLEX; SKIN; SKIN BLOOD FLOW; SYMPATHETIC NERVE; VASOCONSTRICTION; VASODILATATION;

ADRENERGIC ALPHA-AGONISTS; ADULT; AXONS; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; MICRODIALYSIS; MIDDLE AGED; NERVE FIBERS, UNMYELINATED; NOREPINEPHRINE; PHENYLEPHRINE; RECEPTORS, ADRENERGIC, ALPHA; REFERENCE VALUES; REFLEX; SKIN; VASOCONSTRICTION;

EID: 1642316060     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00990.2003     Document Type: Article

References (28)

1. Ali Z, Raja SN, Wesselmann U, Fuchs PN, Meyer RA, and Campbell JN. Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Pain 99: 161-168, 2000.
2. 6 spinal nerve ligation in monkey. J Neurophysiol 81: 455-466, 1999.
3. Baron R, Schattschneider J, Binder A, Siebrecht D, and Wasner G. Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study. Lancet 359: 1655-1660, 2002.
4. Baron R, Wasner G, Borgstedt R, Hastedt E, Schulte H, Binder A, Kopper F, Rowbotham M, Levine JD, and Fields HL. Effect of sympathetic activity on capsaicin-evoked pain, hyperalgesia, and vasodilatation. Neurology 52: 923-932, 1999.
5. Bickel A, Krämer HH, Hilz MJ, Birklein F, Neundorfer B, and Schmelz M. Assessment of the neurogenic flare reaction in small fiber neuropathies. Neurology 59: 917-919, 2002.
6. Birklein F, Weber M, and Neundorfer B. Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia? Neurology 55: 1213-1215, 2000.
7. Brain SD and Williams TJ. Substance P regulates the vasodilator activity of calcitonin gene-related peptide. Nature 335: 73-75, 1988.
8. Drummond PD. Enhancement of thermal hyperalgesia by alpha-adrenoceptors in capsaicin-treated skin. J Auton Nerv Syst 69: 96-102, 1998.
9. Drummond PD. Nitroprusside inhibits thermal hyperalgesia induced by noradrenaline in capsaicin-treated skin. Pain 80: 405-412, 1999.
10. Drummond PD. Prior iontophoresis of saline enhances vasoconstriction to phenylephrine and clonidine in the skin of the human forearm. Br J Clin Pharmacol 54: 45-50, 2002.
11. Drummond PD and Lipnicki DM. Noradrenaline provokes axon reflex hyperaemia in the skin of the human forearm. J Auton Nerv Syst 77: 39-44, 1999.
12. Drummond PD and Lipnicki DM. Repeated local administration of noradrenaline or saline inhibits thermal hyperalgesia in pain-sensitized human skin. Br J Clin Pharmacol 52: 289-295, 2001.
13. Elam M, Olausson B, Skarphedinsson JO, and Wallin BG. Does sympathetic nerve discharge affect the firing of polymodal C-fibre afferents in humans? Brain 122: 2237-2244, 1999.
14. Fuchs PN, Meyer RA, and Raja SN. Heat, but not mechanical hyperalgesia, following adrenergic injections in normal human skin. Pain 90: 15-23, 2001.
15. Grossmann M, Jamieson MJ, Kellogg DL Jr, Kosiba WA, Pergola PE, Crandall CG, and Shepherd AM. The effect of iontophoresis on the cutaneous vasculature: evidence for current-induced hyperemia. Microvasc Res 50: 444-452, 1995.
16. a. Henriksen O. Sympathetic reflex control of blood flow in human peripheral tissues. Acta Physiol Scand Suppl 603: 33-39, 1991.
17. Holzer P. Neurogenic vasodilatation and plasma leakage in the skin. Gen Pharmacol 30: 5-11, 1998.
18. Kinnman E, Nygards E, and Hansson P. Peripheral alpha-adrenoreceptors are involved in the development of capsaicin induced ongoing and stimulus evoked pain in humans. Pain 69: 79-85, 1997.
19. Kress M and Fickenscher H. Infection by human varicella-zoster virus confers norepinephrine sensitivity to sensory neurons from rat dorsal root ganglia. FASEB J 15: 1037-1043, 2001.
20. Lewis T. The nocifensor system of nerves and its reactions. Br Med J 1: 491-494, 1937.
21. Lischetzki G, Rukwied R, Handwerker HO, and Schmelz M. Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin. Eur J Pain 5: 49-57, 2001.
22. Magerl W and Treede RD. Heat-evoked vasodilatafion in human hairy skin: axon reflexes due to low-level activity of nociceptive afferents. J Physiol 497: 837-848, 1996.
23. 2 induces vasodilation and pruritus, but no protein extravasation in atopic dermatitis and controls. J Am Acad Dermatol 47: 28-32, 2002.
24. Sato J and Perl ER. Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science 251: 1608-1610, 1991.
25. Schmelz M, Luz O, Averbeck B, and Bickel A. Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis. Neurosci Lett 230: 117-120, 1997.
26. Torebjörk E, Wahren LK, Wallin G, Hallin R, and Koltzenburg M. Noradrenaline-evoked pain in neuralgia. Pain 63: 11-20, 1995.
27. Weidner C, Klede M, Rukwied R, Lischetzki G, Neisius U, Skov PS, Petersen LJ, and Schmelz M. Acute effects of substance P and calcitonin gene-related peptide in human skin - a microdialysis study. J Invest Dermatol 115: 1015-1020, 2000.
28. Westerman RA, Pano I, Rabavilas A, Hahn A, Nunn A, Roberts RG, and Burry H. Reflex sympathetic dystrophy: altered axon-reflexes and autonomic responses. Clin Exp Neurol 29: 210-233, 1992.