An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cells

Biochemical Journal

Volumn 378, Issue 2, 2004, Pages 409-419

  Gandhi, Payal M ^a   Gibson, Richard M ^a   Tong, Xiaofeng ^a   Miyoshi, Jun ^b   Takai, Yoshimi ^c   Konieczkowski, Martha ^d   Sedor, John R ^a,d   Wilson Delfosse, Amy L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Cytoskeleton; Localization; Rac1; RhoGDI (Rho family specific GDP dissociation inhibitor); Targeting

Indexed keywords

BIOLOGICAL MEMBRANES; LIVING SYSTEMS STUDIES; MUTAGENESIS;

MEMBRANE RUFFLING; PLASMA MEMBRANE;

CELLS;

EPIDERMAL GROWTH FACTOR; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; MUTANT PROTEIN; RAC1 PROTEIN; RHO FACTOR;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MEMBRANE; CELL STRAIN COS7; CYTOSOL; GENETIC TRANSFECTION; KNOCKOUT MOUSE; MAMMAL CELL; MESANGIUM CELL; MOLECULAR DYNAMICS; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; GLOMERULAR MESANGIUM; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MUTATION; PROTEIN TRANSPORT; RAC1 GTP-BINDING PROTEIN; RECOMBINANT FUSION PROTEINS;

ANIMALIA; MAMMALIA;

EID: 1642307142     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030979     Document Type: Article

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