GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase

Blood

Volumn 103, Issue 7, 2004, Pages 2601-2609

  Marshall, Stuart J ^b   Senis, Yotis A ^a   Auger, Jocelyn M ^b   Feil, Robert ^b   Hofmann, Franz ^b   Salmon, Gary ^b   Peterson, J Thomas ^b   Burslem, Frank ^b   Watson, Steve P ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; ALPHA2B INTEGRIN; BETA3 INTEGRIN; COLLAGEN; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GLYCOPROTEIN IB; GLYCOPROTEIN IB IX V; LOTRAFIBAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (BETA DEXTRO GLUCOPYRANOSYL) N2 ACETYL S NITROSOPENICILLAMINAMIDE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE DONOR; PD 173952; PD 184161; PHOSPHODIESTERASE V INHIBITOR; PROTEIN TYROSINE KINASE; RISTOCETIN; SILDENAFIL; THROMBIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN METABOLISM; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROCESS MONITORING; RABBIT; SHEAR FLOW; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOGENESIS; THROMBOSIS;

EID: 1642278417     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-09-3319     Document Type: Article

References (47)

1. Jackson SP, Nesbitt WS, Kulkarni S. Signaling events underlying thrombus formation. J Thromb Haemost. 2003;1:1602-1612.
2. Celikel R, McClintock RA, Roberts JR, et al. Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha. Science. 2003;301:218-221.
3. Savage B, Saldivar E, Ruggeri ZM. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell. 1996;84:289-297.
4. Ruggeri ZM. Von Willebrand factor, platelets and endothelial cell interactions. J Thromb Haemost. 2003;1:1335-1342.
5. Nieswandt B, Brakebusch C, Bergmeier W, et al. Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. EMBO J. 2001;20:2120-2130.
6. Atkinson BT, Jarvis GE, Watson SP. Activation of GPVI by collagen is regulated by alpha2beta1 and secondary mediators. J Thromb Haemost. 2003;1:1278-1287.
7. Jin J, Kunapuli SP. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Acad Sci U S A. 1998;95:8070-8074.
8. Nieswandt B, Bergmeier W, Eckly A, et al. Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation. Blood. 2001;97:3829-3835.
9. Yap CL, Hughan SC, Cranmer SL, et al. Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin alpha IIbbeta 3: studies in human platelets and transfected Chinese hamster ovary cells. J Biol Chem. 2000;275:41377-41388.
10. Marshall SJ, Asazuma N, Best D, et al. Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway. Biochem J. 2002;361:297-305.
11. Mangin P, Yuan Y, Goncalves I, et al. Signaling role for PLCgamma 2 in platelet glycoprotein Ibalpha calcium flux and cytoskeletal reorganization involvement of a pathway distinct from FcR gamma-chain and cgamma RIIA. J Biol Chem. 2003;278:32880-32891.
12. Wu Y, Suzuki-Inoue K, Satoh K, et al. Role of Fc receptor gamma-chain in platelet glycoprotein Ib-mediated signaling. Blood. 2001;97:3836-3845.
13. Kroll MH, Harris TS, Moake JL, et al. von Willebrand factor binding to platelet GpIb initiates signals for platelet activation. J Clin Invest. 1991;88:1568-1573.
14. Torti M, Bertoni A, Canobbio I, et al. Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation. J Biol Chem. 1999;274:13690-13697.
15. Kulkarni S, Dopheide SM, Yap CL, et al. A revised model of platelet aggregation. J Clin Invest. 2000;105:783-791.
16. Mazzucato M, Pradella P, Cozzi MR, et al. Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibalpha mechanoreceptor. Blood. 2002;100:2793-2800.
17. Nesbitt WS, Kulkarni S, Giuliano S, et al. Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow. J Biol Chem. 2002;277:2965-2972.
18. Nesbitt WS, Giuliano S, Kulkarni S, et al. Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol. 2003;160:1151-1161.
19. Yap CL, Anderson KE, Hughan SC, et al. Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3). Blood. 2002;99:151-158.
20. Ozaki Y, Satoh K, Yatomi Y, et al. Protein tyrosine phosphorylation in human platelets induced by interaction between glycoprotein Ib and von Willebrand factor. Biochim Biophys Acta. 1995;1243:482-488.
21. Falati S, Edmead CE, Poole AW. Glycoprotein Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc receptor gamma-chain, Fyn, and Lyn to activate human platelets. Blood. 1999;94:1648-1656.
22. Asazuma N, Ozaki Y, Satoh K, et al. Glycoprotein Ib-von Willebrand factor interactions activate tyrosine kinases in human platelets. Blood. 1997;90:4789-4798.
23. Yanabu M, Ozaki Y, Nomura S, et al. Tyrosine phosphorylation and p72syk activation by an antiglycoprotein Ib monoclonal antibody. Blood. 1997;89:1590-1598.
24. Li Z, Xi X, Gu M, et al. A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell. 2003;112:77-86.
25. Li Z, Xi X, Du X. A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3. J Biol Chem. 2001;276:42226-42232.
26. Wegener JW, Nawrath H, Wolfsgruber W, et al. cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium. Circ Res. 2002;90:18-20.
27. Best D, Senis YA, Jarvis GE, et al. GPVI levels in platelets: relationship to platelet function at high shear. Blood. 2003;102:2811-2818.
28. Golino P, Ambrosio G, Pascucci I, el al. Experimental carotid stenosis and endothelial injury in the rabbit: an in vivo model to study intravascular platelet aggregation. Thromb Haemost. 1992;67:302-305.
29. Folts JD, Crowell EB Jr, Rowe GG. Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation. 1976;54:365-370.
30. Edgington ES. Randomization Tests. 3rd ed. New York, NY: Marcel Dekker; 1995.
31. Kraker AJ, Hartl BG, Amar AM, et al. Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3- d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000;60:885-898.
32. Wonerow P, Pearce AC, Vaux DJ, et al. A critical role for phospholipase Cgamma 2 in alpha IIbeta 3-mediated platelet spreading. J Biol Chem. 2003;278:37520-37529.
33. Goncalves I, Hughan SC, Schoenwaelder SM, et al. Integrin alpha IIbbeta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow: involvement of PLCgamma 2. J Biol Chem. 2003;278:34812-34822.
34. Briddon SJ, Watson SP. Evidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets. Biochem J. 1999;338:203-209.
35. Wallis RM, Corbin JD, Francis SH, et al. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am J Cardiol. 1999;83:3C-12C.
36. Bain J, McLauchlan H, Elliott M, et al. The specificities of protein kinase inhibitors: an update. Biochem J. 2003;371:199-204.
37. Gambaryan S, Schwarz UR, Butt E, et al. Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase. Blood. 2004;103:2593-2600.
38. Li Z, Ajdic J, Eigenthaler M, et al. A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans. Blood. 2003;101:4423-4429.
39. Haslam RJ, Dickinson NT, Jang EK. Cyclic nucleotides and phosphodiesterases in platelets. Thromb Haemost. 1999;82:412-423.
40. Jang EK, Azzam JE, Dickinson NT, et al. Roles for both cyclic GMP and cyclic AMP in the inhibition of collagen-induced platelet aggregation by nitroprusside. Br J Haematol. 2002;117:664-675.
41. Aktas B, Honig-Liedl P, Walter U, et al. Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase. Biochem Pharmacol. 2002;64:433-439.
42. Borsch-Haubold AG, Pasquet S, Watson SP. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059: SB 203580 also inhibits thromboxane synthase. J Biol Chem. 1998;273:28766-28772.
43. Song S, Freedman J, Mody M, et al. Porcine von Willebrand factor and thrombin induce the activation of c-Jun amino-terminal kinase (JNK/SAPK) whereas only thrombin induces activation of extracellular signal-related kinase 2 (ERK2) in human platelets. Br J Haematol. 2000;109:851-856.
44. McNicol A, Jackson EC. Inhibition of the MEK/ERK pathway has no effect on agonist-induced aggregation of human platelets. Biochem Pharmacol. 2003;65:1243-1250.
45. Sambrano GR, Weiss EJ, Zheng YW, et al. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature. 2001;413:74-78.
46. Inoue O, Suzuki-Inoue K, Dean WL, et al. Integrin {alpha}2{beta}1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLC{gamma}2. J Cell Biol. 2003;160:769-780.
47. Mangin P, Nonne C, Eckly A, et al. A PLCgamma2-platelet collagen aggregation requiring functional association of GPVI and integrin alpha(2)beta(1). FEBS Lett. 2003;542:53-59.