Stuart Schreiber: Biology from a chemist's perspective

Drug Discovery Today

Volumn 9, Issue 7, 2004, Pages 299-303

  Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Biochemistry; Chembank; Chemical Biology; Drug Discovery; Natural products; NIH roadmap; Pharma; Pharmaceutical Science; Protein microarray technology; Protein protein interactions

Indexed keywords

HEAT SHOCK PROTEIN 90; NANOPARTICLE; NEW DRUG;

ACADEMIC ACHIEVEMENT; CANCER RESEARCH; CHEMICAL GENETICS; CHEMISTRY; CIRCADIAN RHYTHM; CLINICAL RESEARCH; DNA EXTRACTION; DRUG DETERMINATION; DRUG MARKETING; DRUG RESEARCH; HUMAN; HUMAN GENOME; LABORATORY; MEDICAL SPECIALIST; PROTEIN FUNCTION; PROTEIN MICROARRAY; REVIEW; RNA STRUCTURE;

EID: 1642275433     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(04)03063-6     Document Type: Note

References (8)

1. Liu J., et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 66:1991;807-815.
2. Schreiber S.L. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science. 287:2000;1964-1969.
3. Burke, M.D. and Schreiber, S.L. (2004) A planning algorithm for diversity-oriented synthesis. Angew. Chem.43, 46-58
4. Brady S.F., et al. Cloning and heterologous expression of a natural product biosynthetic gene. Org. Lett. 3:2001;1981-1984.
5. Taunton J., et al. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 272:1996;408-411.
6. Kuruvilla F.G., et al. Dissecting glucose signaling with diversity-oriented synthesis and small molecule microarrays. Nature. 416:2002;653-656.
7. Haggarty S. J., et al. Domain-selective small molecule inhibitor of HDAC6-mediated tubulin deacetylation. Proc. Natl. Acad. Sci. U. S. A. 100:2003;4389-4394.
8. Kawal A., et al. A high affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature. 425:2003;407-410.