Priming in vivo and quantification in vitro of class I MHC-restricted cytotoxic T cells to human papilloma virus type 11 early proteins (E6 and E7) using immunostimulating complexes (ISCOMs)

Vaccine

Volumn 14, Issue 3, 1996, Pages 230-236

  Tarpey, Ian ^a,d   Stacey, Simon N ^b   McIndoe, Angus ^c   Davies, D Huw ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

cytotoxic T lymphocytes; ISCOM; limiting dilution analysis

Indexed keywords

HYBRID PROTEIN; ISCOM; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; RECOMBINANT VACCINE; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNIZATION; IMMUNOSTIMULATION; INTRAPERITONEAL DRUG ADMINISTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; WART VIRUS;

EID: 0029996188     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0264-410X(95)00179-5     Document Type: Article

References (30)

1. Morein, B. and Simons, K. Subunit vaccines against enveloped viruses: virosomes, micelles and other protein complexes. Vaccine 1985, 3, 83-93
2. Morein, B. The Iscom: an immunostimulating system. Immunol. Lett. 1990, 25, 281-283
3. Mowat, A. and Donachie, A.M. Iscoms - a novel strategy for mucosal immunization? Immunol. Today 1991, 12, 383-385
4. Jones, P.D., Tha Hla, R., Morein, B. and Ada, G.L. Cellular immune responses in the murine lung to local immunization with influenza A virus glycoproteins in micelles and immunostimulatory complexes (iscoms). Scand. J. Immunol. 1988, 27, 645-652
5. + cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs. Nature 1990, 344, 873-875
6. + cytotoxic T lymphocytes towards soluble antigens: immunostimulating-ovalbumin complexes enter the class I MHC-restricted antigen pathway and allow sensitization against the immunodominant peptide. Eur. J. Immunol. 1991, 21, 1523-1527
7. Mowat, A.McI., Donachie, A.M., Reid, G. and Jarrett, O. Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic taken by the oral route. Immunology 1991, 72, 317-322
8. Mowat, A.McI., Malloy, K.J. and Donachie, A.M. Immunestimulating complexes as adjuvants for inducing local and systemic immunity after oral immunization with protein antigens. Immunology 1993, 80, 527-534
9. van Binnendijk, R.S., van Baalen, C.A., Poelen, M.C.M. et al. Measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for HLA class I- and class II-restricted cytotoxic T cell recognition. J. Exp. Med. 1992, 176, 119-128
10. Reddy, R., Zhou, F., Nair, S., Huang, L. and Rouse, B.T. In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes. J. Immunol. 1992, 148, 1585-1589
11. Collins, D.S., Findlay, K. and Harding, C.V. Processing of endogenous liposome-encapsulated antigens in vivo generated class I MHC-restricted T cell responses. J. Immunol. 1992, 148, 3336-3341
12. Watson, D.L., Lövgren, K., Watson, N.A., Fossum, C., Morein, B. and Hoglund, S. Inflammatory response and antigen localization following immunization with influenza virus ISCOMs. Inflammation 1989, 13, 641-649
13. Watson, D.L., Watson, N.A., Fossum, C., Lövgren, K. and Morein, B. Interactions between immune-stimulating complexes (ISCOMs) and peritoneal mononuclear leucocytes. Microbiol. Immunol. 1992, 36, 199-203
14. Maloy, K.J., Donachie, A.M., O'Hagan, D.T. and Mowat, A.McI. Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-coglycoside) microparticles. Immunology 1994, 81, 661-667
15. Herrington, C.S. Human papillomaviruses and cervical neoplasia. I. Classification, virology, pathology and epidemiology. J. Clin. Pathol. 1994, 47, 1066-1072
16. Vousden, K. H. Mechanisms of transformation by HPV. In: Human Papillomaviruses in Cervical Cancer. Biology and Immunology (Eds Stern, P.L. and Stanley, M.A.). Oxford Medical Publications, Oxford, 1994, pp. 92-115
17. Bradford, M.M. A rapid and sensitive method for the quantitiation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254
18. Tarpey, I., Stacey, S., Hickling, J. et al. Human cytotoxic T lymphocytes stimulated by endogenously-processed human papillomavirus type 11 E7 recognize a peptide containing an HLA-A2 (A*0201) motif. Immunology 1994, 81, 222-227
19. Morein, B., Ekstrom, J. and Lövgren, K. Increased immunogenicity of a non-amphipathic protein (BSA) after inclusion into ISCOMs. J. Immunol. Meth. 1990, 128, 177-181
20. van Pel, A., DePlaen, E. and Boon, T. Selection of a highly transfectable variant from mouse mastocytoma P815. Somat. Cell. Mol. Genet. 1985, 11, 467-475
21. Gorer, P.A. Studies in antibody response of mice to tumor inoculation. Br. J. Cancer 1950, 4, 372-376
22. Chain, B.M., McCafferty, I., Wallace, G. and Askenase, P.W. Improvement of the in vitro T cell proliferation assay by a modified method that separates the antigen recognition and IL-2-dependent steps. J. Immunol. Meth. 1987, 99, 221-228.
23. Macatonia, S.E., Taylor, P.M., Knight, S.C. and Askonas, B.A. Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro. J. Exp. Med. 1989, 169, 1255-1264
24. Ozel, M., Hoglund, S., Gelderblom, H.R. and Morein, B. Quaternary structure of the immunostimulating complex (iscom). J. Ultrastruct. Molec. Struct. Res. 1989, 102, 240-248
25. Gao, L., Chain, B., Sinclair, C. et al. Immune response to human papilloma virus type 16 E6 gene in a live vaccinia virus vector. J. Gen. Virol. 1994, 75, 157-164
26. Sadovnikova, E., Zhu, X., Collins, S.M. et al. Limitations of predictive motifs revealed by cytotoxic T lymphocyte epitope mapping of the human papilloma virus E7 protein. Int. Immunol. 1994, 6, 289-296
27. Romani, N., Gruner, S., Brang, D. et al. Proliferating dendritic cell progenitors in human blood, J. Exp. Med. 1994, 180, 83-93
28. Kast, W.M., Brandt, R.M.P., Drijfhout, J.W. and Melief, C.J.M. Human leukocyte antigen-A2. 1 restricted candidate cytotoxic T lymphocyte epitopes of human papillomavirus type 16 E6 and E7 proteins identified by using the procesing-defective human cell line T2. J. Immunother. 1993, 14, 115-120
29. Kast, W.M., Brandt, R.M., Sidney, J. et al. Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins. J. Immunol. 1994, 152, 3904-3912
30. Davies, D.H., Tarpey, I., Stacey, S. et al. Human cytotoxic T cell epitopes in HPV 11: relationships between allele-specific motifs, HLA binding, and stimulation in vitro. In: Immunology of Human Papillomaviruses (Ed. Stanley, M.A.). Plenum Press, New York, 1994, pp. 227-232