Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 29, 2004, Pages 10697-10702

  Davis, Ian D ^a,b   Chen, Weisan ^a   Jackson, Heather ^a   Parente, Phillip ^a,b   Shackleton, Mark ^a,b   Hopkins, Wendie ^a   Chen, Qiyuan ^a   Dimopoulos, Nektaria ^a   Luke, Tina ^a   Murphy, Roger ^a   Scott, Andrew M ^a,b   Maraskovsky, Eugene ^a   McArthur, Grant ^c   MacGregor, Duncan ^b   Sturrock, Sue ^b   Tai, Tsin Yee ^a   Green, Simon ^d   Cuthbertson, Andrew ^d   Maher, Darryl ^d   Miloradovic, Lena ^d   Mitchell, Susan V ^d   Ritter, Gerd ^a   Jungbluth, Achim A ^a   Chen, Yao Tseng ^a,e   Gnjatic, Sacha ^a   Hoffman, Eric W ^a   Old, Lloyd J ^a   Cebon, Jonathan S ^a,b   more..

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^b AUSTIN HOSPITAL   (Australia)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

^d CSL LIMITED   (Australia)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; IMMUNOLOGICAL ADJUVANT; ISCOMATRIX ADJUVANT; NY ESO 1 PROTEIN; PLACEBO; RECOMBINANT PROTEIN; SAPONIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CANCER RECURRENCE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DRUG POTENCY; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEVER; HEADACHE; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOGENICITY; INJECTION SITE; INJECTION SITE PAIN; MELANOMA; MINIMAL RESIDUAL DISEASE; MYALGIA; PAIN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ADJUVANTS, IMMUNOLOGIC; ANTIBODIES, NEOPLASM; ANTIGENS, NEOPLASM; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EPITOPES; HUMANS; MALE; MELANOMA; MEMBRANE PROTEINS; PLACEBOS; RECOMBINANT PROTEINS; SAPONINS; TESTIS; TREATMENT OUTCOME;

EID: 3242658810     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0403572101     Document Type: Article

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