메뉴 건너뛰기




Volumn 44, Issue 10, 2005, Pages 1560-1563

Reversible cross-linking of hyperbranched polymers: A strategy for the combinatorial decoration of multivalent scaffolds

Author keywords

Combinatorial chemistry; Drug delivery; Peptides; Polymers; Solid phase synthesis

Indexed keywords

CELLS; CONCENTRATION (PROCESS); CROSSLINKING; RESINS; SYNTHESIS (CHEMICAL);

EID: 16244423031     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200460559     Document Type: Article
Times cited : (16)

References (32)
  • 5
    • 0037091001 scopus 로고    scopus 로고
    • d) S.-E. Stiriba, H. Frey, R. Haag, Angew. Chem, 2002, 114, 1385-1390; Angew. Chem. Int. Ed. 2002, 41, 1329-1334.
    • (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 1329-1334
  • 8
    • 0032476812 scopus 로고    scopus 로고
    • M. Mammen, S.-K. Choi, G. M. Whitesides, Angew. Chem. 1998, 110, 2908-2953; Angew. Chem. Int. Ed. 1998, 37, 2755-2794.
    • (1998) Angew. Chem. Int. Ed. , vol.37 , pp. 2755-2794
  • 11
    • 0003418177 scopus 로고    scopus 로고
    • (Eds.: J. M. J. Fréchet, D. A. Tomalia), Wiley, Chichester
    • b) Dendrimers and Other Dendritic Polymers (Eds.: J. M. J. Fréchet, D. A. Tomalia), Wiley, Chichester, 2001.
    • (2001) Dendrimers and other Dendritic Polymers
  • 12
    • 0006349853 scopus 로고
    • In classic organic synthesis on dissolved polymers, various polyols were employed: a) M. Mutter, E. Bayer, Angew. Chem. 1974, 86, 101-102; Angew. Chem. Int. Ed. Engl. 1974, 13, 88-89;
    • (1974) Angew. Chem. , vol.86 , pp. 101-102
    • Mutter, M.1    Bayer, E.2
  • 13
    • 0006385243 scopus 로고
    • In classic organic synthesis on dissolved polymers, various polyols were employed: a) M. Mutter, E. Bayer, Angew. Chem. 1974, 86, 101-102; Angew. Chem. Int. Ed. Engl. 1974, 13, 88-89;
    • (1974) Angew. Chem. Int. Ed. Engl. , vol.13 , pp. 88-89
  • 18
    • 2542556232 scopus 로고    scopus 로고
    • J. Rademann, M. Barth, Angew. Chem. 2002, 114, 3087-3090; Angew. Chem. Int. Ed. 2002, 41, 2975-2978.
    • (2002) Angew. Chem. , vol.114 , pp. 3087-3090
    • Rademann, J.1    Barth, M.2
  • 19
    • 0037119321 scopus 로고    scopus 로고
    • J. Rademann, M. Barth, Angew. Chem. 2002, 114, 3087-3090; Angew. Chem. Int. Ed. 2002, 41, 2975-2978.
    • (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 2975-2978
  • 26
    • 16244376742 scopus 로고    scopus 로고
    • For comparison, in a recent publication 50 μM of a fluorophore-labeled trimeric peptide was required for detectable incorporation in HeLa cells: J. Fernandez-Carneado, M. J. Kogan, S. Castel, E. Giralt, Angew. Chem. 2004, 116, 1847-1850; Angew. Chem. Int. Ed. 2004, 43, 1811-1814.
    • (2004) Angew. Chem. , vol.116 , pp. 1847-1850
    • Fernandez-Carneado, J.1    Kogan, M.J.2    Castel, S.3    Giralt, E.4
  • 27
    • 3142774800 scopus 로고    scopus 로고
    • For comparison, in a recent publication 50 μM of a fluorophore-labeled trimeric peptide was required for detectable incorporation in HeLa cells: J. Fernandez-Carneado, M. J. Kogan, S. Castel, E. Giralt, Angew. Chem. 2004, 116, 1847-1850; Angew. Chem. Int. Ed. 2004, 43, 1811-1814.
    • (2004) Angew. Chem. Int. Ed. , vol.43 , pp. 1811-1814
  • 28
    • 3042670499 scopus 로고    scopus 로고
    • The fragmentation of a macroscopic polymer to give a modified, multivalent structure as described in this article must be clearly distinguished from the numerous works on enzymatically or chemically cleavable dendrimers. Cleavable dendrimers are fragmented into monorneric building blocks, and thereby the multivalent character is lost. Two recent examples on triggered dendrimer cleavage are: a) F. M. H. de Groot, C. Albrecht, R. Koekkoek, P. H. Beusker, H. W. Scheeren, Angew. Chem. 2003, 115, 4628-4632; Angew. Chem. Int. Ed. 2003, 42, 4490-4494;
    • (2003) Angew. Chem. , vol.115 , pp. 4628-4632
    • De Groot, F.M.H.1    Albrecht, C.2    Koekkoek, R.3    Beusker, P.H.4    Scheeren, H.W.5
  • 29
    • 0141670339 scopus 로고    scopus 로고
    • The fragmentation of a macroscopic polymer to give a modified, multivalent structure as described in this article must be clearly distinguished from the numerous works on enzymatically or chemically cleavable dendrimers. Cleavable dendrimers are fragmented into monorneric building blocks, and thereby the multivalent character is lost. Two recent examples on triggered dendrimer cleavage are: a) F. M. H. de Groot, C. Albrecht, R. Koekkoek, P. H. Beusker, H. W. Scheeren, Angew. Chem. 2003, 115, 4628-4632; Angew. Chem. Int. Ed. 2003, 42, 4490-4494;
    • (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 4490-4494
  • 31
    • 0141447389 scopus 로고    scopus 로고
    • b) J. R. Amir, N. Pessah, M. Shamis, D. Shabat, Angew. Chem. 2003, 115, 4632-4636; Angew. Chem. Int. Ed. 2003, 42, 4494-4499.
    • (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 4494-4499
  • 32
    • 16244417717 scopus 로고    scopus 로고
    • note
    • Polyethylene imine was selected as the most inexpensive commercially available starting polymer. In principle, the protocol should be applicable for other branched polyamines including amine dendrimers.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.