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The fragmentation of a macroscopic polymer to give a modified, multivalent structure as described in this article must be clearly distinguished from the numerous works on enzymatically or chemically cleavable dendrimers. Cleavable dendrimers are fragmented into monorneric building blocks, and thereby the multivalent character is lost. Two recent examples on triggered dendrimer cleavage are: a) F. M. H. de Groot, C. Albrecht, R. Koekkoek, P. H. Beusker, H. W. Scheeren, Angew. Chem. 2003, 115, 4628-4632; Angew. Chem. Int. Ed. 2003, 42, 4490-4494;
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0141670339
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The fragmentation of a macroscopic polymer to give a modified, multivalent structure as described in this article must be clearly distinguished from the numerous works on enzymatically or chemically cleavable dendrimers. Cleavable dendrimers are fragmented into monorneric building blocks, and thereby the multivalent character is lost. Two recent examples on triggered dendrimer cleavage are: a) F. M. H. de Groot, C. Albrecht, R. Koekkoek, P. H. Beusker, H. W. Scheeren, Angew. Chem. 2003, 115, 4628-4632; Angew. Chem. Int. Ed. 2003, 42, 4490-4494;
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note
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Polyethylene imine was selected as the most inexpensive commercially available starting polymer. In principle, the protocol should be applicable for other branched polyamines including amine dendrimers.
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