Leukemia inhibitory factor is linked to regulatory transplantation tolerance

Transplantation

Volumn 79, Issue 6, 2005, Pages 726-730

  Metcalfe, Su M ^a,d   Watson, Tracy J ^a   Shurey, Sandra ^b   Adams, Elizabeth ^c   Green, Colin J ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Signal transduction; Tolerance; Transplantation

Indexed keywords

CYTOKINE; INTERLEUKIN 10; LEUKEMIA INHIBITORY FACTOR; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3;

ALLOIMMUNITY; ANIMAL CELL; ARTICLE; CELL POPULATION; CELL TYPE; CLONE; COMPARATIVE STUDY; CYTOKINE RELEASE; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; IN VIVO STUDY; KINETICS; LYMPH NODE; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPLEEN CELL; TH1 CELL; TH2 CELL; TRANSPLANTATION TOLERANCE;

ANIMALS; CELLS, CULTURED; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR; MICE; MICE, INBRED BALB C; PROTEINS; SPLEEN; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TRANS-ACTIVATORS; TRANSPLANTATION TOLERANCE;

EID: 16244415192     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000149324.42994.38     Document Type: Article

References (18)

1. Levy DE, Darnell JE. STATs: transcriptional control and biological impact. Nature Rev Mol Cell Biol 2002; 3: 651.
2. Reiner SL. Helper T cell differentiation, inside and out. Curr Opin Immunol 2001; 13: 351.
3. O'Shea JJ, Paul WE. Regulation of Th1 differentiation - controlling the controllers. Nat Immunol 2002; 3: 506.
4. Sakagushi S. Regulatory T cells: key controllers of immunological self-tolerance. Cell 2000; 101: 455.
5. Roncarolo MG, Bacchetta R, Bordignon C, et al. Type 1 T regulatory cells. Immunol Rev 2001; 182: 68.
6. Ramsdell F, Ziegler SF. Transcription factors in autoimmunity. Curr Opin Immunol 2003; 15: 718.
7. Shevach E. Certified professionals: CD4+CD25+ suppressor cells. J Exp Med 2001; 193: F41.
8. Waldmann H, Graca L, Cobbold S, et al. Regulatory T cells and organ transplantation. Semin Immunol 2004; 16: 119.
9. Ramsdell F. Foxp3 and natural regulatory T cells: key to a cell lineage? Immunity 2003; 19: 165.
10. Levings MK, Sangregorio R, Roncarolo MG. Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001; 193: 1295.
11. Hara M, Kingsley CI, Niimi M, et al. IL10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 2001; 166: 3789.
12. Chen ZK, Cobbold SP, Waldmann H, et al. Amplification of natural regulatory immune mechanisms for transplantation tolerance. Transplantation 1996; 62: 1200.
13. Metcalfe SM, Moffatt-Bruce SD. An ex vivo model of tolerance versus rejection: Comparison of STAT1, STAT4, STAT5 and STAT6. Clin Chem and Lab Med 2000; 38: 1195.
14. Paradis H, Gendron RL. LIF transduces contradictory signals on capillary outgrowth through induction of Stat3 and (P41/43)MAP kinase. J Cell Sci 2000; 113: 4331.
15. Metcalf D. Unsolved enigmas of leukaemia inhibitory factor. Stem Cells 2003; 21: 5.
16. Zelenika D, Adams E, Humm S, et al. Regulatory T cells overexpress a subset of Th2 gene transcripts. J Immunol 2002; 168: 1069.
17. Murray P, Edgar D. The regulation of embryonic stem cell differentiation by leukaemia inhibitory factor (LIF). Differentiation 2001; 68: 227.
18. Piccinni MP, Scaletti C, Mavilia C, et al. Production of IL4 and LIF by T cells of the cumulus oophorus. Euro J Immunol 2001; 31: 2431.