Inhibition of epidermal growth factor receptor tyrosine kinase by chalcone derivatives

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1550, Issue 2, 2001, Pages 144-152

  Yang, Er Bin ^a   Guo, Yong Jian ^b   Zhang, Kai ^a   Chen, Yu Zong ^b   Mack, Peter ^a  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Epidermal growth factor receptor; Molecular modeling; Plant polyphenol; Tyrosine kinase

Indexed keywords

BUTEIN; CHALCONE DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; MAREIN; PHLORETIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROXYLATION; IN VITRO STUDY; LIVER CELL CARCINOMA; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING;

AMINO ACID SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CHALCONE; CHALCONES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMAL GROWTH FACTOR; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHLORETIN; PHOSPHODIESTERASE INHIBITORS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035905545     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(01)00276-X     Document Type: Article

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