Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions

Inflammation Research

Volumn 54, Issue 2, 2005, Pages 66-73

  Nagaoka, I ^a   Kuwahara Arai, K ^a   Tamura, H ^b   Hiramatsu, K ^a   Hirata, M ^c  

^a JUNTENDO UNIVERSITY   (Japan)

^b SEIKAGAKU CORPORATION   (Japan)

^c Insititute of Ohtaka Enzyme Co   (Japan)

Author keywords

Amino acid substitution; Antibacterial peptide; Cathelicidin; Hydrophilicity; Hydrophobicity

Indexed keywords

ANTIINFECTIVE AGENT; CATHELICIDIN DERIVATIVE; PEPTIDE; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; CATHELICIDIN ANTIMICROBIAL PEPTIDE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; ASSAY; BACTERIAL MEMBRANE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG SCREENING; ESCHERICHIA COLI; HUMAN; HUMAN CELL; HYDROPHOBICITY; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE ACTIVITY RELATION; ANIMAL; BACTERIUM; CELL SURVIVAL; DRUG EFFECT; GENETICS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MACROPHAGE; METABOLISM; MONOCYTE; MOUSE; PHYSIOLOGY;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; MACROPHAGES; MICE; MONOCYTES;

EID: 16244385591     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00011-004-1323-8     Document Type: Article

References (40)

1. Hancock REW, Diamond G. The role of cationic antimicrobial peptides in innate host defences. Trends Microbiol 2000; 8: 402-10.
2. Risso A. Leukocyte antimicrobial peptides: multifunctional effector molecules of innate immunity. J Leukoc Biol 2000; 68: 785-92.
3. Lehrer RI, Lichtenstein AK, Ganz T. Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu Rev Immunol 1993; 11: 1005-28.
4. Martin E, Ganz T, Lehrer RI. Defensins and other endogenous peptide antibiotics of vertebrates. J Leukoc Biol 1995; 58: 128-36.
5. Lehrer RI, Ganz T. Defensins of vertebrate animals. Curr Opin Immunol 2002; 14: 96-102.
6. Zanetti M, Gennaro R, Romeo D. Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett 1995; 374: 1-5.
7. Gennaro R, Zanetti M. Structural features and biological activities of the cathelicidin-derived antimicrobial peptides. Biopolymers 2000; 55: 31-49.
8. Gudmundsson GH, Agerberth B. Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system. J Immunol Methods 1999; 232: 45-54.
9. Lehrer RI, Ganz T. Cathelicidins: a family of endogenous antimicrobial peptides. Curr Opin Hematol 2002; 9: 18-22.
10. Nagaoka I, Hirota S, Yomogida S, Ohwada A, Hirata M. Synergistic actions of antibacterial neutrophil defensins and Cathelicidins. Inflamm Res 2000; 49: 73-9.
11. Larrick JW, Hirata M, Zhong J, Wright SC. Anti-microbial activity of human CAP18 peptides. Immunotechnology 1995; 1: 65-72.
12. Larrick JW, Hirata M, Balint RF, Lee J, Zhong J, Wright SC. Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. Infect Immun 1995; 63: 1291-7.
13. Kirikae T, Hirata M, Yamasu H, Kirikae F, Tamura H, Kayama F, et al. Protective effects of a human 18-killodalton cationic antimicrobial protein (CAP18)-derived peptide against murine endotoxemia. Infect Immun 1998; 66: 1861-8.
14. Levy O. Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents. Blood 2000; 96: 2664-72.
15. + cells. J Immunol 2001; 167: 3364-73.
16. Turner J, Cho Y, Dinh NN, Waring AJ, Lehrer RI. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob. Agents Chemother 1998; 42: 2206-14.
17. Yomogida S, Nagaoka I, Yamashita T. Purification of the 11- and 5-kDa antibacterial polypeptides from guinea pig neutrophils. Arch Biochem Biophys 1996; 328: 219-26.
18. Nagaoka I, Tsutsumi-Ishii Y, Yomogida S, Yamashita T. Isolation of cDNA encoding guinea pig neutrophil cationic antibacterial polypeptide of 11 kDa (CAP11) and evaluation of CAP11 mRNA expression during neutrophil maturation. J Biol Chem 1997; 272: 22742-50.
19. Tossi A, Sandri L, Giangaspero A. Amphipathic, α-helical antimicrobial peptides. Biopolymers 2000; 55: 4-30.
20. Giangaspero A, Sandri L, Tossi A. Amphipathic α helical antimicrobial peptides. A systematic study of the effects of structural and physical properties on biological activity. Eur J Buiochem 2001; 268: 5589-600.
21. Tenover F, Swenson JM, O'Hara CM, Stocker SA. Ability of commercial and reference antimicrobial susceptibility testing methods to detect vancomycin resistance in enterococci. J Clin Microbiol 1995; 33: 1524-7.
22. Yajko DM, Madej JJ, Lancaster MV, Sanders CA, Cawthon VL, Gee B et al. Colorimetric method for determining MICs of antimicrobial agents for Mycrobacterium tuberculosis. J Clin Microbiol 1995; 33: 2324-7.
23. DeForge LE, Billeci KL, Kramer SM. Effect of IFN-γ on the killing of S. aureus in human whole blood. Assessment of bacterial viability by CFU determination and by a new method using alamarBlue. J Immunol Methods 2000; 245: 79-89.
24. Ohwada A, Sekiya M, Hanaki H, Kuwahara-Arai K, Nagaoka I, Hori S et al. DNA vaccination by mecA sequence evokes an antibacterial immune response against methicillin-resistant Staphylococcus aureus. J Antimicrob Chemothr 1999; 44: 767-74.
25. Gennaro R, Scocchi M, Merluzzi L, Zanetti M. Biological characterization of a novel mammalian antimicrobial peptide. Biochem Biophys Acta 1998; 1425: 361-8.
26. Lehrer RI, Barton A, Ganz T. Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry. J Immunol Methods 1988; 108: 153-8.
27. Lehrer RI, Barton A, Daher KA, Harwig SSL, Ganz T, Selsted ME. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest 1989; 84: 553-61.
28. Hancock REW, Lehrer R. Cationic peptides: a new source of antibiotics. Trends Biotechnol 1998; 16: 82-8.
29. Hancock REW, Scott MG. The role of antimicrobial peptides in animal defenses. Proc Natl Acad Sci USA 2000; 97: 8856-61.
30. Matsuzaki K. Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes. Biochim Biophys Acta 1999; 1462: 1-10.
31. Hancock RE, Speert DP. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment. Drug Resist Updat 2000; 3: 247-55.
32. Lambert PA. Mechanisms of antibiotic resistance in Pseudomonas aeruginosa. J R Soc Med 2002; 95: 22-6.
33. Mah TFC, O'Toole GA. Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 2001; 9: 34-9.
34. Kharazmi A. Mechanisms involved in the evasion of the host defence by Pseudomonas aeruginosa. Immunol Lett 1991; 30: 201-5.
35. Erridge C, Bennett-Guerrero E, Poxton IR. Structure and function of lipopolysaccharides. Microbes Infect 2002; 4: 837-51.
36. Sørensen O, Bratt T, Johnsen AH, Madsen MT, Borregaard N. The human antibacterial cathelicidin, hCAP18, is bound to lipoproteins in plasma. J Biol Chem 1999; 274: 22445-51.
37. Sawa T, Kurahashi K, Ohara M, Gropper M, Doshi V, Larrick JW et al. Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model. Antimicrob Agents Chemother 1998; 42: 3269-75.
38. Oren Z, Lerman JC, Gudmundsson GH, Agerberth B, Shai Y. Structure and organization of the human antimicrobial LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity. Biochem J 1999; 501-13.
39. Hancock REW, Chapple DS. Peptide antibiotics. Antimicrob Agents Chemother 1999; 43: 1317-23.
40. Giroir, BP, Scannon PJ, Levin M. Bactericidal/permeability-increasing protein-lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia. Crit Care Med 2001; 29: S130-5.