Synthesis, local anaesthetic and antiarrhythmic activity of methyl N-(2-substituted aminopropanoyl)-3-cyanoanthranilates

Bollettino Chimico Farmaceutico

Volumn 135, Issue 7, 1996, Pages 415-420

  Al Obaid, Abdul Rahman M A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

cyanoanthranilates; lidocaine; local anaesthetic and antiarrhythmic activity; tocainide

Indexed keywords

ANTHRANILIC ACID DERIVATIVE; ANTIARRHYTHMIC AGENT; LIDOCAINE; LOCAL ANESTHETIC AGENT; TOCAINIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORNEA; DRUG SYNTHESIS; FROG; GUINEA PIG; HEART ARRHYTHMIA; INTRAVENOUS DRUG ADMINISTRATION; LOCAL ANESTHESIA; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RABBIT; RAT; TOPICAL DRUG ADMINISTRATION;

ANESTHETICS, LOCAL; ANIMALS; ANTHRANILIC ACIDS; ANTI-ARRHYTHMIA AGENTS; FEMALE; GUINEA PIGS; IRRITANTS; MALE; MUSCLE CONTRACTION; RABBITS; RANA PIPIENS; RATS;

EID: 0030481359     PISSN: 00066648     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Mackenzie T.A., Young E.R., Anesth. Prog. 40: 29 (1993).
2. Chow M.S., Lebsack C., Hilleman D., Clinical Pharmacy 7: 869 (1988).
3. Al-Obaid A.M., Alex. J. Pharm. Sci. 6: 43 (1992).
4. Nixon W.J.Jr, Garland J.T., Blanton C.D.Jr., Synthesis 56 (1980).
5. Vaidya N.A., Nixon W.J., Fatami A.A., Blanton C.D.Jr., J. Org. Chem. 47: 2483 (1982).
6. Cutler S.J., El-Kabbani F.M., Keane C., Fisher-Shore S.L., Blanton C.D.Jr., Heteocycles 31: 651 (1990).
7. Cutler S.J., El-Kabbani F.M., Keane C., Fisher-Shore S.L., McCabe F.L., Johnson R.K., Blanton C.D.Jr., Eur. J. Med. Chem. 28: 407 (1993).
8. Vaidya N.A., Panos C.H., Kite A., Iturrian W.B., Blanton C.D.Jr., J. Med. Chem. 26: 1422 (1983).
9. Vaidya N.A., Blanton C.D.Jr., J. Org. Chem. 47: 1777 (1982).
10. Fatami A.A., Vaidya N.A., Iturrian W.B., Blanton C.D.Jr. (1984), J. Med. Chem. 27: 772.
11. Korolkovas A. Essentials of Medicinal Chemistry, Wiley Interscience, New York 1988.
12. Elks J., Ganellin C.R. Dictionary of Drugs, Chapman and Hall, New York 1990.
13. Gewald K., Chem. Ber. 99: 1002 (1966).
14. Al-Rashood K.A., Madani A.E., Ginawi O.T., Ashraf S.A., El-Obeid H.A., Arzneim-Forsch/Drug Res. 40,11: 1242 (1990).
15. Bulbring E., Wajda I. (1945), J. Pharmacol. Exp. Therp. 85: 78.
16. Solman T., J. Pharmacol. Exp. Ther. 11: 107 (1958).
17. Madan B.R., Madan V., Pendse V.K., Gupta R.S., Arch. Int. Pharmacodyn, Ther. 185: 53 (1970).
18. Camongis G., Takman B.H., in Methods of Pharmacology, A. Schwartz (ed.), vol. 1, Chap. 1, Appleton-Century Graft, New York 1971.
19. ElTahir K.E.H., Al-Obeid H.A., Al-Rashood K.A, Madani A.Z.E., Ageel A.M., Pharm. Res. 6: 252 (1989).