Synthesis and biological evaluation of new cyclopenteno[b]thiophene derivatives as local anesthetic and antiarrhythmic agents

Pharmazie

Volumn 53, Issue 1, 1998, Pages 24-28

  Al Obaid, A M ^a   El Subbagh, H I ^a   Al Shabanah, O A ^a   Mahran, M A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; ARTICAINE; CALCIUM CHANNEL; CYCLOPENTANE DERIVATIVE; CYCLOPENTANO[B]THIOPHENE DERIVATIVE; LIDOCAINE; LOCAL ANESTHETIC AGENT; SODIUM CHANNEL; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CORNEA REFLEX; DOSE RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; FROG; GUINEA PIG; HEART RATE; IN VITRO STUDY; INTRAOCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIMB; LOCAL ANESTHESIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RABBIT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANESTHETICS, LOCAL; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; CALCIUM CHLORIDE; CARTICAINE; CORNEA; GUINEA PIGS; LETHAL DOSE 50; MALE; OUABAIN; RABBITS; RATS; RATS, WISTAR; THIOPHENES;

EID: 0031972986     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Foye, W.; Lemke, T.; Williams, D.: Principles of Medicinal Chemistry, p 305, Williams & Wikins, Media PA, USA 1995
2. Verderame, M.: Handbook of CNS Agents and Local Anesthetics, p. 336, CRC Press, Florida, USA 1986
3. Budavari, S.: Merck Index, 11th ed., p. 285, Merck and Co. Inc., Rahway, NJ, USA 1989
4. Roth, H. J.; Kleemann, A.: Pharmaceutical Chemistry, Drug Synthesis, p. 209, Ellis Horwood Ltd., Chichester, England 1988
5. Al-Obaid, A. M.: Arzneim.-Forsch. 45, 627 (1995)
6. Al-Obaid, A. M.: Alex. J. Pharm. Sci. 6, 43 (1992)
7. Al-Obaid, A. M. Boll. Chim. Pharmaceutico 135, 239 (1996)
8. Staff Department of Pharmacology, University of Edinburgh, Pharmacological Experiments on intact preparations, Churchill Living Press, London 1971
9. Goldberg, L.: Acta Physiol. Scand. 18, 1 (1949)
10. El-Tahir, K. E. H.; El-Obeid, H. A.; Al-Rashood, K. A.; Madani, A. E.; Ageel, A. M.: Pharm. Res. 6, 252 (1989)
11. Thomas, G. P.; Tripathi, R. M.: Br. J. Pharmacol. 89, 385 (1986)
12. Gewald, K.: Chem. Ber. 98, 3571 (1965)
13. Gissen, A. J.; Covina, B.; Gerus, J.: Anesthesiology (USA), supplement 5217, 51, 3 (1979)
14. Fleckenslein, A.: Ann. Rev. Pharmacol. Toxicol, 17, 149 (1977)
15. Eisner, D. A.: J. Exp. Physiol. 75, 437 (1990)
16. Weir, W. G.; Hess, P.: J. Gen. Physiol. 83, 395 (1984)
17. Marban, E.; Tsien, R. W.: J. Physiol. 329, 589 (1982)
18. McGarry, S. J.; Williams, A. J.: Br. J. Pharmacol. 108, 1043 (1993)
19. Vaughan, E. M.: J. Clin. Pharmacol. 24, 129 (1984)