Local anesthetic and antiarrhythmic activity of certain new 1,3,4- thiadiazole derivatives

Saudi Pharmaceutical Journal

Volumn 6, Issue 3-4, 1998, Pages 228-234

  El Sherbeny, Magda A ^a   Al Obaid, Abdul Rahman M A ^a   El Kashef, Hassan A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

1,3,4 thiadiazoles; Antiarrhythmic agents; Local anesthetic agents

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; ANTIARRHYTHMIC AGENT; ARTICAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FROG; GUINEA PIG; LOCAL ANESTHESIA; NONHUMAN; RABBIT; RAT; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0031775431     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Foye W, Lemke T and Williams D. Principles of Medicinal Chemistry P. 305, Williams, Wikins, Media PA, USA 1995.
2. th ed, P. 302 New York Macmilan, 1985.
3. Liljestrand G. The Historical Development of Local Anesthetics In Lechat P. (ed.) Local Anesthetic International Encyclopedia of Pharmacology and Therapeutics Sect, 8, 1 P.1 New York Pergamon Press 1971.
4. th ed, P. 285, Merch and Co. Inc. Rahway NJ, USA 1989.
5. Roth HJ, Kleemann A. Pharmaceutical Chemistry, Drug Synthesis, P. 209, Ellis Horwood Ltd, Chichester, England 1988.
6. Verderame M. Handbook of CNS Agents and Local Anesthetics, P. 336, CRC Press, Florida, USA. 1986.
7. Al-Obaid AM. Synthesis of polysubstituted 2-(2-substituted aminoacetamido) benzoate ester as potential local anesthetic agents Alex J Pharm Sci. 1991; 6 : 43-46.
8. Al-Obaid AM. Synthesis of 2-[[1-oxo-2-(substituted amino)propyl]amino]-4,5,6,7-tetra-hydrobenzo[b] thiophene-3-carboxylic acid ethyl esters as potential local anesthetic agents. Arzneim-Forsch 1995; 45 : 627-630.
9. Al-Obaid AM. Synthesis, local anesthetic and antiarrhythmic activity of methyl N-(2-substituted aminopropanoyl)-3-cyanoanthranilate. Boll Chim Pharmacutico 1996, 135:415-420.
10. Al-Obaid AM, El-Subbagh HI, Shabanah OA and Mahran MA. Synthesis and biological evaluation of certain new cyclopenteno[b] thiophene derivatives as local anesthetic and antiarrhythmic agents. Die Pharmazie 1998; 53 : 24-28.
11. Shakya AK, Patnaik GK and Mishra P. Synthesis and biological evaluation of 2-[substituted acetyl]amino-5-alkyl-l,3,4-thiadiazoles. Eur J Med Chem 1992; 27 : 67-71.
12. Phillips GB, Morgan TK, Lumma WC, Gomez RP, Lind JM, Argentieri T and Sullivan ME. Synthesis, cardiac electrophysiology and ?-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agent. J Med Chem 1992; 35: 743-750.
13. Caliendo G, Greco G, Grieco P, Mattace Raso G, Meli R, Novellino E, Perissutti E and Santagada V. Synthesis and pharmacological evaluation of a set of N-[2-(alkylamino) ethyl] benzotriazol-x-yl isobutyramides acting as local anesthetic. Eur J Med Chem 1996; 31: 99-110.
14. Staff Department of Pharmacology, University of Edinburgh, Pharmacological Experiments on Intact Preparation, Churchill Living Press, London 1971.
15. El-Tahir KEH, El-Obeid HA, Al-Rashood KA, Madani AE and Ageel AM. The antiarrhythmic activity of N-alkyl-1, 2-diphenylethanol-amine. Pharm Res 1989; 6 : 252-255.
16. Litchfield JT and Wilcoxon T. A simplified method of evaluating dose effect experiments. J Pharmacol Exp Ther 1949; 96: 99-109.