Direct metabolic regulation of β-catenin activity by the p85α regulatory subunit of phosphoinositide 3-OH kinase

Experimental Cell Research

Volumn 305, Issue 2, 2005, Pages 409-417

  Espada, Jesús ^a,b   Peinado, Héctor ^b   Esteller, Manel ^a   Cano, Amparo ^b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

Glutathione synthase kinase; p85 ; Phosphoinositide 3 OH kinase; catenin

Indexed keywords

APC PROTEIN; BETA CATENIN; CATENIN; GLYCOGEN SYNTHASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; PROTEIN SERINE THREONINE KINASE; UVOMORULIN; WNT PROTEIN;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CATALYSIS; CELL ADHESION; COMPLEX FORMATION; CONTROLLED STUDY; CORNEA CELL; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SUBUNIT; METABOLIC REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

STAPHYLOCOCCUS PHAGE 3A;

EID: 16244362676     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2005.01.009     Document Type: Article

References (29)

1. H. Aberle, A. Bauer, J. Stappert, A. Kispert, and R. Kemler β-catenin is a target of the ubiquitin-proteasome pathway EMBO J. 16 1997 3797 3804
2. M. Bienz, and H. Clevers Linking colorectal cancer to Wnt signaling Cell 103 2000 311 320
3. R.H. Chen, W.V. Ding, and F. McCormick Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C J. Biol. Chem. 275 2000 17894 17899
4. S.L. Christian, P.V. Sims, and M.R. Gold The B cell antigen receptor regulates the transcriptional activator β-catenin via protein kinase C-mediated inhibition of glycogen synthase kinase 3 J. Immunol. 169 2002 758 769
5. D.A. Cross, D.R. Alessi, P. Cohen, M. Andjelkovich, and B.A. Hemmings Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378 1995 785
6. M. Delcommenne, C. Tan, V. Gray, L. Rue, J. Woodgett, and S. Dedhar Phosphoinositide 3-OH kinase dependent regulation of glycogen synthase kinase-3 and protein kinase B/Akt by the integrin-linked kinase Proc. Natl. Acad. Sci. 95 1998 11211 11216
7. J. Espada, M.A. Pérez-Moreno, V.M.M. Braga, P. Rodriguez-Viciana, and A. Cano H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of β-catenin in epidermal keratinocytes J. Cell Biol. 146 1999 967 980
8. D.A. Fruman, R.E. Meyers, and L.C. Cantley Phosphoinositide kinases Annu. Rev. Biochem. 67 1998 481 507
9. S. Goruppi, C. Chiaruttini, M.E. Ruaro, V. Varnum, and C. Schneider Gas6 induces growth, β-catenin stabilization and T-call factor transcriptional activation in contact-inhibited C57 mammary cells Mol. Cell. Biol. 21 2001 902 915
10. M. Hart, J.P. Concordet, I. Lassot, I. Albert, R. del los Santos, H. Durand, C. Perret, B. Rubinfeld, F. Margottin, R. Benarous, and P. Polakis The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell Curr. Biol. 9 1999 207 210
11. L.M. Hedgepeth, L.J. Conrad, J. Zhang, H.C. Huang, V.M. Lee, and P.S. Klein Activation of the Wnt signaling pathway: a molecular mechanism for lithium action Dev. Biol. 185 1997 82 91
12. M. Hashimoto, Y. Sagara, D. Langford, I.P. Everall, M. Mallory, A. Everson, M. Digicaylioglu, and E. Masliah Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase 3β pathway J. Biol. Chem. 277 2002 32985 32991
13. B.R. Henderson Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover Nat. Cell Biol. 2 2000 653 660
14. C. Jiménez, R. Armas-Portela, M. Mellado, J.M. Rodríguez-Frade, J. Collard, A. Serrano, C. Martínez, J. Avila, and A. Carrera Role of the PI3K regulatory subunit in the control of actin organization and cell migration J. Cell Biol. 151 2000 249 261
15. H. Kang, H. Schneider, and C.E. Rudd Phosphatidylinositol 3-kinase p85 adaptor function in T-cells. Co-stimulation and regulation of cytokine transcription independent of associated p110 J. Biol. Chem. 277 2 2002 912 921
16. N.R. Murray, L.A. Davidson, R.S. Chapkin, W. Clay Gustafson, D.G. Schattenberg, and A.P. Fields Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis J. Cell Biol. 145 1999 699 711
17. Y.M. Patel, and M.D. Lane Mitotic clonal expansion during preadipocyte differentiation: calpain-mediated turnover of p27 J. Biol. Chem. 275 2000 17653 17660
18. M.A. Pérez-Moreno, A. Locascio, I. Rodrigo, G. Dhont, F. Portillo, M.A. Nieto, and A. Cano A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions J. Biol. Chem. 276 2001 27424 27431
19. L.E. Rameth, and L.C. Cantley The role of phosphoinositide 3-kinase lipid products in cell function J. Biol. Chem. 274 1999 8347 8350
20. P. Rodriguez-Viciana, P.H. Warne, A. Khwaja, B.M. Marte, D. Pappin, P. Das, M.D. Waterfield, A. Ridley, and J. Downward Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras Cell 89 1997 457 467
21. R.F. Rosin-Arbesfeld, F.F. Townsley, and M. Bienz The APC tumour suppressor has a nuclear export function Nature 406 2000 1009 1012
22. W.J. Ryves, L. Fryer, T. Dale, and A.J. Harwood An assay for glycogen synthase kinase 3 (GSK3) for use in crude cell extracts Anal. Biochem. 264 1998 124 127
23. M. Sharma, W.W. Chuang, and Z. Sun Phosphatydilinositol-3 kinase/Akt stimulates androgen pathway through GSK3β inhibition and nuclear β-catenin accumulation J. Biol. Chem. 277 2002 30935 30941
24. M. Takeichi Cadherin cell adhesion receptors as morphogenetic regulators Science 251 1991 1451 1455
25. K. Ueki, C.M. Yballe, S.M. Brachmann, D. Vicent, J.M. Watt, R. Kahn, and L. Cantley Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase Proc. Natl. Acad. Sci. 99 2002 419 424
26. R.J. Woodfield, M.N. Hodgkin, N. Akhtar, M.A. Morse, K.J. Fuller, K. Saqib, N.T. Thompson, and M.J.O. Wakelam The p85 subunit of phosphoinositide 3-kinase is associated with β-catenin in the cadherin-based adhesion complex Biochem. J. 360 2001 335 344
27. Z. Xie, X. Zeng, T. Waldman, and R.I. Glazer Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 activates beta-catenin and c-Myc, and downregulates caveolin-1 Cancer Res. 63 2003 5370 5375
28. J. Yu, Y. Zhang, J. McIlroy, T. Rordorf-Nikolic, G.A. Orr, and J.M. Backer Regulation of the p85/p110 phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit Mol. Cell. Biol. 18 1998 1379 1387
29. L. Zhang, L. Song, and E.M. Parker Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the substrate gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production J. Biol. Chem. 274 1999 8966 8972