The p85 subunit of phosphoinositide 3-kinase is associated with β-catenin in the cadherin-based adhesion complex

Biochemical Journal

Volumn 360, Issue 2, 2001, Pages 335-344

  Woodfield, R J ^a   Hodgkin, M N ^a   Akhtar, N ^a   Morse, M A ^a   Fuller, K J ^a   Saqib, K ^a   Thompson, N T ^a   Wakelam, M J O ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Cell cell adhesion; Epithelia; PI 3 kinase; Protein interactions

Indexed keywords

CELLS; CYTOLOGY; ENZYMES; TISSUE;

CELL ADHESION;

BIOCHEMISTRY;

BETA CATENIN; CADHERIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SUBUNIT;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL ADHESION; COMPLEX FORMATION; DISSOCIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WOUND HEALING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BETA CATENIN; CADHERINS; CATALYTIC DOMAIN; CELL ADHESION; CELL LINE; CYTOSKELETAL PROTEINS; DOGS; EPIDERMAL GROWTH FACTOR; GLUTATHIONE TRANSFERASE; HUMANS; KERATINOCYTES; MACROMOLECULAR SUBSTANCES; PEPTIDE FRAGMENTS; PRECIPITATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATORS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0035629458     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3600335     Document Type: Article

References (44)

1. Cell adhesion: Old and new questions
2. Molecular and functional analysis of cadherin-based adherens junctions
3. Morphogenetic roles of classic cadherins
4. Protocadherins and diversity of the cadherin superfamily
5. Expressed recombinant cadherins mediate cell sorting in model systems
6. Cadherins: A molecular family important in selective cell-cell adhesion
7. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species
8. Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule
9. Assembly of the cadherin-catenin complex in vitro with recombinant proteins
10. Ligand activation of overexpressed epidermal growth factor receptor results in colony dissociation and disturbed E-cadherin function in HSC-1 human cutaneous squamous carcinoma cells
11. The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton
12. Hepatocyte growth factor/scatter factor disrupts epithelial tumour cell-cell adhesion: Involvement of beta-catenin
13. Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly
14. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-Src gene
15. Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts
16. The effect of tyrosine protein phosphorylation on the assembly of the adherens-type junctions
17. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and P13-kinase
18. Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit
19. Pathway of phosphatidylinositol (3,4,5)-trisphosphate synthesis in activated neutrophils
20. 2 3-OH kinase
21. The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor
22. Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits
23. Oncogenes and signal transduction
24. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex
25. Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
26. Interaction between the epidermal growth factor receptor and phosphoinositide kinases
27. Activated type 1 phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation
28. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
29. Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation
30. Functional domains of the pp60v-src protein as revealed by analysis of temperature-sensitive Rous sarcoma virus mutants
31. Intracellular localization and processing of pp60v-src proteins expressed by two distinct temperature-sensitive mutants of Rous sarcoma virus
32. Development of a yeast trihybrid screen using stable yeast strains and regulated protein expression
33. Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T-cells
34. Mapping of a yeast G protein βγ signaling interaction
35. SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity
36. H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes
37. Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration
38. Biochemical interactions in the wnt pathway
39. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
40. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
41. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
42. The generation of lipid signalling molecules in the nucleus
43. Nuclear localisation signal-independent and importin/karyopherin-independent nuclear import of beta-catenin