Towards targeting signalling networks by functional phosphoproteomics

Drug Discovery Today: TARGETS

Volumn 1, Issue 5, 2002, Pages 169-176

  Godovac Zimmermann, Jasminka ^a,b   Brown, Larry R ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b PROTEOSYS AG   (Germany)

^c NONE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CASEIN; IMATINIB; PHOSPHOPROTEIN; TRASTUZUMAB;

ANALYTIC METHOD; AUTOMATION; BREAST CANCER; CHRONIC MYELOID LEUKEMIA; DRUG INDUSTRY; DRUG TARGETING; EXTRACTION; MASS SPECTROMETRY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEOMICS; PUBLICATION; REPRODUCIBILITY; REVIEW; SIGNAL TRANSDUCTION; TECHNOLOGY;

EID: 15944426382     PISSN: 17418372     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1477-3627(02)02217-1     Document Type: Review

References (29)

1. Fambrough, D. et al. (1999) Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97, 727-741
2. Sweeney, C. et al. (2001) Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors. J. Biol. Chem. 276, 22685-22698
3. Petley, T. et al. (1999) Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses. Horm. Metab. Res. 31, 70-76
4. Baserga, R. and Morrione, A. (1999) Differentiation and malignant transformation: two roads diverged in a wood. J. Cell. Biochem. Suppl. 32-33, 68-75
5. Mochly-Rosen, D. and Kauvar, L.M. (1998) Modulating protein kinase C signal transduction. Adv. Pharmacol. 44, 91-145
6. Godovac-Zimmermann, J. and Brown, L.R. (2001) Perspectives for Mass Spectrometry and Functional Proteomics. Mass Spectrom. Rev. 20, 1-57
7. Soskic, V. et al. (1999) Functional proteomics analysis of signal transduction pathways of the platelet-derived growth factor beta receptor. Biochemistry 38, 1757-1764
8. Godovac-Zimmermann, J. et al. (1999) Functional proteomics of signal transduction by membrane receptors. Electrophoresis 20, 952-961
9. McLachlin, D.T. and Chait, B.T. (2001) Analysis of phosphorylated proteins and peptides by mass spectrometry. Curr. Opin. Chem. Biol. 5, 591-602
10. Mann, M. et al. (2002) Analysis of protein phosphorylation using mass spectrometry: deciphering the phosphoproteome. Trends Biotechnol. 20, 261-268
11. Cohen, P. (2002) Protein kinases-the major drug targets of the twenty-first century? Nat. Rev. Drug Discov. 1, 309-315
12. Metcalf, C.A. 3rd et al. (2002) Targeting protein kinases for bone disease: discovery and development of SRC inhibitors. Curr. Pharm. Des. 8, 2049-2075
13. Hardcastle, I.R. et al. (2002) Designing inhibitors of cyclin-dependent kinases. Annu. Rev. Pharmacol. Toxicol. 42, 325-348
14. Scapin, G. (2002) Structural biology in drug design: selective protein kinase inhibitors. Drug Discov. Today 7, 601-611
15. Steed, P.M. and Chow, A.H. (2001) Intracellular signaling by phospholipase D as a therapeutic target. Curr. Pharm. Biotechnol. 2, 241-256
16. Adjei, A.A. (2001) Ras signaling pathway proteins as therapeutic targets. Curr. Pharm. Des. 7, 1581-1594
17. Owa, T. et al. (2001) Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. Curr. Med. Chem. 8, 1487-1503
18. Bockaert, J. et al. (2002) G protein-coupled receptors: dominant players in cell-cell communication. Int. Rev. Cytol. 212, 63-132
19. Wise, A. et al. (2002) Target validation of G-protein coupled receptors. Drug Discov. Today 7, 235-246
20. George, S.R. et al. (2002) G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat. Rev. Drug Discov. 1, 808-820
21. El-Deiry, W.S. (2001) Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling. Cell Death Differ. 8, 1066-1075
22. Shawver, L.K. et al. (2002) Smart drugs: tyrosine kinase inhibitors in cancer therapy. Cancer Cell 1, 117-123
23. Liebmann, C. and Bohmer, F.D. (2000) Signal transduction pathways of G protein-coupled receptors and their cross-talk with receptor tyrosine kinases: lessons from bradykinin signaling. Curr. Med. Chem. 7, 911-943
24. Predic, J. et al. (2002) Monitoring of Gene Expression by Functional Proteomics. Biochemistry 41, 1070-1078
25. Henzel, W.J. et al. (1993) Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases. Proc. Natl. Acad. Sci. U. S. A. 90, 5011-5015
26. Pappin, D.J.C. et al. (1993) Rapid identification of proteins by peptide-mass fingerprinting. Curr. Biol. 3, 327-332
27. Yates, J.R., Iii et al. (1993) Peptide mass maps: a highly informative approach to protein identification. Anal. Biochem. 214, 397-408
28. Clauser, K.R. et al. (1995) Rapid mass spectrometric peptide sequencing and mass matching for characterization of human melanoma proteins isolated by two-dimensional PAGE. Proc. Natl. Acad. Sci. U. S. A. 92, 5072-5076
29. Wilkins, M.R. et al. (1997) Detailed peptide characterization using PEPTIDEMASS-a World- Wide-Web-accessible tool. Electrophoresis 18, 403-408