Thiopurine methyltransferase (TPMT) heterozygosity and enzyme activity as predictive tests for the development of azathioprine-related adverse events

Journal of the Neurological Sciences

Volumn 231, Issue 1-2, 2005, Pages 71-80

  Heckmann, Jeannine M ^a   Lambson, Elisabetta M T ^b   Little, Francesca ^c   Owen, Elizabeth P ^b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

African; Azathioprine; Pharmacogenetics; Pharmacogenomics; Thiopurine methyl transferase; TPMT

Indexed keywords

ACETYLSALICYLIC ACID; ALLOPURINOL; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; AZATHIOPRINE; ISOSORBIDE DINITRATE; THIAZIDE DIURETIC AGENT; THIOPURINE METHYLTRANSFERASE; THYROID HORMONE;

ADULT; ARTHRALGIA; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIARRHEA; DROWSINESS; DRUG ERUPTION; DRUG HYPERSENSITIVITY; ENZYME ACTIVITY; ETHNIC DIFFERENCE; FEMALE; FEVER; FLU LIKE SYNDROME; GASTROINTESTINAL SYMPTOM; GENETIC ANALYSIS; GENOTYPE; HEMATOLOGIC DISEASE; HETEROZYGOSITY; HUMAN; LEUKOPENIA; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MUTATION; MYALGIA; NAUSEA; NEUTROPENIA; PANCREATITIS; PANCYTOPENIA; PREDICTION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; VOMITING;

EID: 15944394455     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2005.01.003     Document Type: Article

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