New insights into leptin resistance by modifying cytokine receptor signal transduction

European Journal of Endocrinology

Volumn 152, Issue 3, 2005, Pages 333-334

  Dötsch, Jörg ^a,b   Rascher, Wolfgang ^a   Meißner, Udo ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; CARRIER PROTEIN; CYTOKINE RECEPTOR; LEPTIN; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; SUPPRESSOR OF CYTOKINE SIGNALING 3;

FOOD INTAKE; GENE EXPRESSION; HORMONE ACTION; HORMONE RESISTANCE; HYPOTHALAMUS; NONHUMAN; NOTE; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WEIGHT GAIN;

ANIMALS; DRUG RESISTANCE; HUMANS; LEPTIN; RECEPTORS, CYTOKINE; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION FACTORS;

EID: 15944371485     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.1.01859     Document Type: Note

References (13)

1. Farooqi IS & O'Rahilly S. Monogenic human obesity syndromes. Recent Progress in Hormone Research 2004 59 409.
2. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, Lubina JA, Patane J, Self B, Hunt P & McCamish M. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. Journal of the American Medical Association 1999 282 1568-1575.
3. Schwartz MW, Peskind E, Raskind M, Boyko EJ & Porte D Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nature Medicine 1996 2 589-593.
4. Dötsch J, Adelmann M, Englaro P, Dötsch A, Hänze J, Blum WF, Kiess W & Rascher W. Relation of leptin and neuropeptide Y in human blood and cerebrospinal fluid. Journal of the Neurological Sciences 1997 151 185-188.
5. Carpenter LR, Farruggella TJ, Symes A, Karow ML, Yancopoulos GD & Stahl N. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor. PNAS 1998 95 6061-6066.
6. Elchebly M, Payette P, Michaliszyn E, Cromlish W Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML & Kennedy BP. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999 283 1544-1548.
7. Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB & Neel BG. PTP1B regulates leptin signal transduction in vivo. Developmental Cell 2002 2 489-495.
8. Cheng A, Uetani N, Simoncic PD, Chaubey VP, Lee-Loy A, McGlade CJ, Kennedy BP & Tremblay ML. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Developmental Cell 2002 2 497-503.
9. Yasukawa H, Sasaki A & Yoshimura A. Negative regulation of cytokine signaling pathways. Annual Review of Immunology 2000 18 143-164.
10. Bjorbaek C, Elmquist JK, Frantz JD, Shoelson SE & Flier JS. Identification of SOCS-3 as a potential mediator of central leptin resistance. Molecular Cell 1998 1 619-625.
11. Roberts AW, Robb L, Rakar S, Hartley L, Cluse L, Nicola NA, Metcalf D, Hilton DJ & Alexander WS. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. PNAS 2001 98 9324-9329.
12. Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C & Flier JS. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nature Medicine 2004 10 734-738.
13. Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H & Yoshimura A. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nature Medicine 2004 10 739-743.