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Volumn 4, Issue 5, 2005, Pages 787-798

Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; CASPASE 2; CASPASE 6; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FLICE INHIBITORY PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6 RECEPTOR; LIPOCORTIN 5; PROTEIN BCL 2; PROTEIN MCL 1; RAF PROTEIN; RAS PROTEIN; SHORT HAIRPIN RNA; TOLL LIKE RECEPTOR 4; VASCULOTROPIN;

EID: 15744392410     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-04-0330     Document Type: Article
Times cited : (50)

References (44)
  • 1
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t(4;14)(p16-3;q32.3) in multiple myeloma: Association with increased expression and activating mutation of fibroblast growth factor receptor 3
    • Chesi M, Nardini E, Brents LA, et al. Frequent translocation t(4;14)(p16-3;q32.3) in multiple myeloma: association with increased expression and activating mutation of fibroblast growth factor receptor 3. Nat Genet 1997;16:260-4.
    • (1997) Nat. Genet. , vol.16 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3
  • 2
    • 2642595047 scopus 로고    scopus 로고
    • The roles of FGFs in the early development of vertebrate limbs
    • Martin GR. The roles of FGFs in the early development of vertebrate limbs. Genes Dev 1998;12:1571-86.
    • (1998) Genes Dev. , vol.12 , pp. 1571-1586
    • Martin, G.R.1
  • 3
    • 0035168141 scopus 로고    scopus 로고
    • Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, stat activation, and phosphatidylinositol 3-kinase activation
    • Hart KC, Robertson SC, Donoghue DJ. Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, stat activation, and phosphatidylinositol 3-kinase activation. Molecular biology of the cell 2001;12:931-42.
    • (2001) Molecular Ciology of the Cell , vol.12 , pp. 931-942
    • Hart, K.C.1    Robertson, S.C.2    Donoghue, D.J.3
  • 4
    • 1842372689 scopus 로고    scopus 로고
    • Signal transduction pathway of human fibroblast growth factor receptor 3: Identification of a novel 66-kDa phosphoprotein
    • Kanai M, Goke M, Tsunekawa S, Podolsky DK. Signal transduction pathway of human fibroblast growth factor receptor 3: identification of a novel 66-kDa phosphoprotein. J Biol chem 1997;272:6621-8.
    • (1997) J. Biol. Chem. , vol.272 , pp. 6621-6628
    • Kanai, M.1    Goke, M.2    Tsunekawa, S.3    Podolsky, D.K.4
  • 5
    • 0035254612 scopus 로고    scopus 로고
    • Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
    • Chesi M, Brents LA, Ely SA, et al. Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma. Blood 2001;97:729-36.
    • (2001) Blood , vol.97 , pp. 729-736
    • Chesi, M.1    Brents, L.A.2    Ely, S.A.3
  • 6
    • 0033472710 scopus 로고    scopus 로고
    • Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32.3) and FGFR3 translocation
    • Otsuki T, Yamada O, Yata K, et al. Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32.3) and FGFR3 translocation. Int J Oncol 1999;15:1205-12.
    • (1999) Int. J. Oncol. , vol.15 , pp. 1205-1212
    • Otsuki, T.1    Yamada, O.2    Yata, K.3
  • 7
    • 0035858985 scopus 로고    scopus 로고
    • Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): Comparative analysis of Y373C, K650E and the novel G384D mutations
    • Ronchetti D, Greco A, Compasso S, et al. Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations. Oncogene 2001;20: 3553-62.
    • (2001) Oncogene , vol.20 , pp. 3553-3562
    • Ronchetti, D.1    Greco, A.2    Compasso, S.3
  • 8
    • 0036799415 scopus 로고    scopus 로고
    • Novel mutation and RNA splice variant of fibroblast growth factor receptor 3 in multiple myeloma patients at diagnosis
    • Soverini S, Terragna C, Testoni N, et al. Novel mutation and RNA splice variant of fibroblast growth factor receptor 3 in multiple myeloma patients at diagnosis. Haematologica 2002;87:1036-40.
    • (2002) Haematologica , vol.87 , pp. 1036-1040
    • Soverini, S.1    Terragna, C.2    Testoni, N.3
  • 9
    • 0035871687 scopus 로고    scopus 로고
    • The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells
    • Li Z, Zhu YX, Plowright EE, et al. The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells. Blood 2001;97:2413-9.
    • (2001) Blood , vol.97 , pp. 2413-2419
    • Li, Z.1    Zhu, Y.X.2    Plowright, E.E.3
  • 10
    • 0034142212 scopus 로고    scopus 로고
    • Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis
    • Plowright EE, Li Z, Bergsagel PL, et al. Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis. Blood 2000;95:992-8.
    • (2000) Blood , vol.95 , pp. 992-998
    • Plowright, E.E.1    Li, Z.2    Bergsagel, P.L.3
  • 11
    • 0037441747 scopus 로고    scopus 로고
    • In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression
    • Keats JJ, Reiman T, Maxwell CA, et al. In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression. Blood 2003;101:1520-9.
    • (2003) Blood , vol.101 , pp. 1520-1529
    • Keats, J.J.1    Reiman, T.2    Maxwell, C.A.3
  • 12
    • 0347286862 scopus 로고    scopus 로고
    • Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia
    • Dvorak P, Dvorakova D, Doubek M, et al. Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia. Leukemia 2003;17:2418-25.
    • (2003) Leukemia , vol.17 , pp. 2418-2425
    • Dvorak, P.1    Dvorakova, D.2    Doubek, M.3
  • 14
    • 20144378471 scopus 로고    scopus 로고
    • Ribozyme cleavage leads to decreased expression of fibroblast growth factor 3 in human multiple myeloma cells, which is associated with apoptosis and down-regulation of vascular endothelial growth factor
    • Qian SX, Somlo G, Zhou B, et al. Ribozyme cleavage leads to decreased expression of fibroblast growth factor 3 in human multiple myeloma cells, which is associated with apoptosis and down-regulation of vascular endothelial growth factor. Oligonucleotides 2005;15:1-11.
    • (2005) Oligonucleotides , vol.15 , pp. 1-11
    • Qian, S.X.1    Somlo, G.2    Zhou, B.3
  • 16
    • 0035281741 scopus 로고    scopus 로고
    • RNA interference
    • Sharp PA. RNA interference. Genes Dev 2001;15:485-90.
    • (2001) Genes Dev. , vol.15 , pp. 485-490
    • Sharp, P.A.1
  • 17
    • 0037089135 scopus 로고    scopus 로고
    • Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor
    • Holen T, Amarzguioui M, Wiiger MT, Babaie E, Prydz H. Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucleic Acids Res 2002;30:1757-66.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 1757-1766
    • Holen, T.1    Amarzguioui, M.2    Wiiger, M.T.3    Babaie, E.4    Prydz, H.5
  • 18
    • 0141537250 scopus 로고    scopus 로고
    • Enhanced gene silencing by the application of multiple specific small interfering RNAs
    • Ji J, Wernli M, Klimkait T, Erb P. Enhanced gene silencing by the application of multiple specific small interfering RNAs. FEBS Lett 2003; 552:247-52.
    • (2003) FEBS Lett. , vol.552 , pp. 247-252
    • Ji, J.1    Wernli, M.2    Klimkait, T.3    Erb, P.4
  • 19
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: Roles in cell survival and oncogenesis
    • Cory S, Huang DC, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003;22:8590-607.
    • (2003) Oncogene , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.2    Adams, J.M.3
  • 21
    • 0031957034 scopus 로고    scopus 로고
    • F. bcl-2 expression in plasma cells from neoplastic gammopathies and reactive plasmacytosis: A comparative study
    • Apr
    • Miguel-Garcia A, Orero T, Matutes E, et al. F. bcl-2 expression in plasma cells from neoplastic gammopathies and reactive plasmacytosis: a comparative study. Haematologica 1998 Apr;83:298-304.
    • (1998) Haematologica , vol.83 , pp. 298-304
    • Miguel-Garcia, A.1    Orero, T.2    Matutes, E.3
  • 22
    • 0033031281 scopus 로고    scopus 로고
    • Differential expression of Bcl-2 in human plasma cell disorders according to proliferation status and malignancy
    • Puthier D, Pellat-Deceunynck C, Barille S, et al. Differential expression of Bcl-2 in human plasma cell disorders according to proliferation status and malignancy. Leukemia 1999;13:289-94.
    • (1999) Leukemia , vol.13 , pp. 289-294
    • Puthier, D.1    Pellat-Deceunynck, C.2    Barille, S.3
  • 23
    • 0037085778 scopus 로고    scopus 로고
    • Myeloid cell factor-1 is a critical survival factor for multiple myeloma
    • Zhang B, Gojo I, Fenton RG. Myeloid cell factor-1 is a critical survival factor for multiple myeloma. Blood 2002;99:1885-93.
    • (2002) Blood , vol.99 , pp. 1885-1893
    • Zhang, B.1    Gojo, I.2    Fenton, R.G.3
  • 24
    • 10744231548 scopus 로고    scopus 로고
    • Identification of genes modulated in multiple myeloma using genetically identical twin samples
    • Munshi NC, Hideshima T, Carrasco D, et al. Identification of genes modulated in multiple myeloma using genetically identical twin samples. Blood 2004;103:1799-806.
    • (2004) Blood , vol.103 , pp. 1799-1806
    • Munshi, N.C.1    Hideshima, T.2    Carrasco, D.3
  • 25
    • 1642553460 scopus 로고    scopus 로고
    • To be, or not to be: NF-κB is the answer-role of Rel/NF-κB in the regulation of apoptosis
    • Kucharczak J, Simmons MJ, Fan Y, Gelinas C. To be, or not to be: NF-κB is the answer-role of Rel/NF-κB in the regulation of apoptosis. Oncogene 2003;22:8961-82.
    • (2003) Oncogene , vol.22 , pp. 8961-8982
    • Kucharczak, J.1    Simmons, M.J.2    Fan, Y.3    Gelinas, C.4
  • 26
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
    • Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J Clin Invest 2001;107:241-6.
    • (2001) J. Clin. Invest. , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 27
    • 1842579486 scopus 로고    scopus 로고
    • Nuclear factor-κB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis
    • Bharti AC, Shishodia S, Reuben JM, et al. Nuclear factor-κB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood 2004;103:3175-84.
    • (2004) Blood , vol.103 , pp. 3175-3184
    • Bharti, A.C.1    Shishodia, S.2    Reuben, J.M.3
  • 28
    • 0036624741 scopus 로고    scopus 로고
    • Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: therapeutic applications. Blood 2002;99:4079-86.
    • (2002) Blood , vol.99 , pp. 4079-4086
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 29
    • 0035207110 scopus 로고    scopus 로고
    • The role of nuclear factor-κB in the biology and treatment of multiple myeloma
    • Berensan JR, Ma HM, Vescio R. The role of nuclear factor-κB in the biology and treatment of multiple myeloma. Semin Oncol 2001;28: 626-33.
    • (2001) Semin. Oncol. , vol.28 , pp. 626-633
    • Berensan, J.R.1    Ma, H.M.2    Vescio, R.3
  • 30
    • 0038792224 scopus 로고    scopus 로고
    • Map kinase signaling pathways and hematologic malignancies
    • Platanias LC. Map kinase signaling pathways and hematologic malignancies. Blood 2003;101:4667-79.
    • (2003) Blood , vol.101 , pp. 4667-4679
    • Platanias, L.C.1
  • 31
    • 0141765902 scopus 로고    scopus 로고
    • New insights into the pathophysiology of multiple myeloma
    • Seidl S, Kaufmann H, Drach J. New insights into the pathophysiology of multiple myeloma. Lancet Oncol 2003;4:557-64.
    • (2003) Lancet Oncol. , vol.4 , pp. 557-564
    • Seidl, S.1    Kaufmann, H.2    Drach, J.3
  • 32
    • 0035869281 scopus 로고    scopus 로고
    • Interleukin-6 is a growth factor for nonmalignant human plasmablasts
    • Jego G, Bataille R, Pellat-Deceunynck C. Interleukin-6 is a growth factor for nonmalignant human plasmablasts. Blood 2001;97:1817-22.
    • (2001) Blood , vol.97 , pp. 1817-1822
    • Jego, G.1    Bataille, R.2    Pellat-Deceunynck, C.3
  • 33
    • 0033168314 scopus 로고    scopus 로고
    • Growth inhibition of a human myeloma cell line by all-trans retinoic acid is not mediated through down-regulation of interleukin-6 receptors but through up-regulation of p21
    • Chen YH, Lavelle D, DeSimone J, Uddin S, Platnnias LC, Hankewych M. Growth inhibition of a human myeloma cell line by all- trans retinoic acid is not mediated through down-regulation of interleukin-6 receptors but through up-regulation of p21. Neoplasia 1999;94:251-9.
    • (1999) Neoplasia , vol.94 , pp. 251-259
    • Chen, Y.H.1    Lavelle, D.2    DeSimone, J.3    Uddin, S.4    Platnnias, L.C.5    Hankewych, M.6
  • 34
    • 0028922433 scopus 로고
    • A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6
    • Guschin D, Rogers N, Briscoe J, et al. A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J 1995;14:1421-9.
    • (1995) EMBO J. , vol.14 , pp. 1421-1429
    • Guschin, D.1    Rogers, N.2    Briscoe, J.3
  • 35
    • 0037780740 scopus 로고    scopus 로고
    • Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity
    • Dang DT, Chen X, Feng J, Torbenson M, Dang LH, Yang VW. Overexpression of Kruppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity. Oncogene 2003;22:3424-30.
    • (2003) Oncogene , vol.22 , pp. 3424-3430
    • Dang, D.T.1    Chen, X.2    Feng, J.3    Torbenson, M.4    Dang, L.H.5    Yang, V.W.6
  • 36
    • 0042093653 scopus 로고    scopus 로고
    • Down-regulation and growth inhibitory effect of epithelial-type Kruppel-like transcription factor KLF4, but not KLF5, in bladder cancer
    • Ohnishi S, Ohnami S, Laub F, et al. Down-regulation and growth inhibitory effect of epithelial-type Kruppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Biochem Biophys Res Commun 2003;308:251-6.
    • (2003) Biochem. Biophys. Res. Commun. , vol.308 , pp. 251-256
    • Ohnishi, S.1    Ohnami, S.2    Laub, F.3
  • 37
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001;411:342-8.
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 38
    • 0034602691 scopus 로고    scopus 로고
    • Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma
    • Shou Y, Martelli ML, Gabrea A, et al. Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma. PNAS 2000;97:228-33.
    • (2000) PNAS , vol.97 , pp. 228-233
    • Shou, Y.1    Martelli, M.L.2    Gabrea, A.3
  • 39
    • 18644386513 scopus 로고    scopus 로고
    • Comparison of gene expression profiling between malignant and normal plasma cells with oligonucleotide arrays
    • De Vos J, Thykjaer T, Tarte K, et al. Comparison of gene expression profiling between malignant and normal plasma cells with oligonucleotide arrays. Oncogene 2002;21:6848-57.
    • (2002) Oncogene , vol.21 , pp. 6848-6857
    • De Vos, J.1    Thykjaer, T.2    Tarte, K.3
  • 40
    • 2342566403 scopus 로고    scopus 로고
    • Targteting FGFR3 in multiple myeloma inhibition of t(4;14)-positive cells by SU5402 and PD173074
    • Grand EK, Chase AJ, Heath C, Rahemtulla A, Cross NC. Targteting FGFR3 in multiple myeloma inhibition of t(4;14)-positive cells by SU5402 and PD173074. Leukemia 2004;18:962-6.
    • (2004) Leukemia , vol.18 , pp. 962-966
    • Grand, E.K.1    Chase, A.J.2    Heath, C.3    Rahemtulla, A.4    Cross, N.C.5
  • 41
    • 1542329588 scopus 로고    scopus 로고
    • Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma
    • Paterson JL, Li Z, Wen XY, et al. Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. Br J Haematol 2004;124:595-603.
    • (2004) Br. J. Haematol. , vol.124 , pp. 595-603
    • Paterson, J.L.1    Li, Z.2    Wen, X.Y.3
  • 42
    • 1942456800 scopus 로고    scopus 로고
    • Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma
    • Trudel S, Ely S, Farooqi Y, et al. Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood 2004;103:3521-8.
    • (2004) Blood , vol.103 , pp. 3521-3528
    • Trudel, S.1    Ely, S.2    Farooqi, Y.3
  • 43
    • 0030945871 scopus 로고    scopus 로고
    • Structures of the tyrosine kinase domain of fibroblast growth factor receptor in comlex with inhibitors
    • Mohammadi M, McMahon G, Sun L, et al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in comlex with inhibitors. Science 1997;276:955-60.
    • (1997) Science , vol.276 , pp. 955-960
    • Mohammadi, M.1    McMahon, G.2    Sun, L.3
  • 44
    • 0034888840 scopus 로고    scopus 로고
    • Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)
    • Intini D, Baldini L, Fabris S, et al. Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14). Br J Haematol 2001;114: 362-4.
    • (2001) Br. J. Haematol. , vol.114 , pp. 362-364
    • Intini, D.1    Baldini, L.2    Fabris, S.3


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