Kinetic analysis of the L-ornithine transcarbamoylase from Pseudomonas savastanoi pv. phaseolicola that is resistant to the transition state analogue (R)-Nδ-(N′-sulfodiaminophosphinyl)-L-ornithine

Biochemistry

Volumn 44, Issue 11, 2005, Pages 4408-4415

  Templeton, Matthew D ^a   Reinhardt, Laurie A ^b   Collyer, Charles A ^c   Mitchell, Robin E ^a   Cleland, W Wallace ^b  

^a THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED   (New Zealand)

^b UNIVERSITY OF WISCONSIN   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; ESCHERICHIA COLI; GENES; ISOTOPES; SUBSTRATES;

ACTIVE COMPONENTS; CARBAMOYL PHOSPHATE (CP); ISOTOPE EFFECT (IE); TRANSITION STATES (TS);

AMINO ACIDS;

BACTERIAL ENZYME; CARBAMOYL PHOSPHATE; CARBON 13; ENZYME INHIBITOR; N DELTA (N' SULFODIAMINOPHOSPHINYL)ORNITHINE; ORNITHINE CARBAMOYLTRANSFERASE; ORNITHINE DERIVATIVE; PHASEOLOTOXIN; PLANT TOXIN; UNCLASSIFIED DRUG;

ARTICLE; AUXOTROPHY; CONFORMATIONAL TRANSITION; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS; PSEUDOMONAS SAVASTANOI PHASEOLICOLA; STEADY STATE; TOXIN SYNTHESIS;

AMINO ACID SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; DEUTERIUM EXCHANGE MEASUREMENT; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; KINETICS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; ORNITHINE; ORNITHINE CARBAMOYLTRANSFERASE; PSEUDOMONAS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 15544384704     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047432x     Document Type: Article

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