1.85-Å Resolution crystal structure of human ornithine transcarbamoylase complexed with N-phosphonacetyl-L-ornithine: Catalytic mechanism and correlation with inherited deficiency

Journal of Biological Chemistry

Volumn 273, Issue 51, 1998, Pages 34247-34254

  Shi, Dashuang ^a   Morizono, Hiroki ^b   Ha, Ya ^a   Aoyagi, Mika ^a   Tuchman, Mendel ^b   Allewell, Norma M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; CARBAMOYL PHOSPHATE; ORNITHINE CARBAMOYLTRANSFERASE; ORNITHINE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; RECOMBINANT ENZYME; DRUG DERIVATIVE; N(DELTA) (PHOSPHONOACETYL) L ORNITHINE; N(DELTA)-(PHOSPHONOACETYL)-L-ORNITHINE; ORNITHINE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME DEFICIENCY; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE MUTATION; HUMAN; HYPERAMMONEMIA; INBORN ERROR OF METABOLISM; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; MACROMOLECULE; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; REPRODUCIBILITY; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI; PROKARYOTA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; ORNITHINE; ORNITHINE CARBAMOYLTRANSFERASE; PROTEIN STRUCTURE, SECONDARY; PSEUDOMONAS AERUGINOSA; REPRODUCIBILITY OF RESULTS; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0032545106     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.51.34247     Document Type: Article

References (22)

1. Snodgrass, P. J. (1968) Biochemistry 7, 3047-3051
2. Tuchman, M., Morizono, H., Rajagopal, B. S., Plante, R. J., and Allewell, N. M. (1998) J. Inherited Metab. Dis. 21, 40-58
3. Morizono, H., Tuchman, M., Rajagopal, B. S., McCann, M. T., Listrom, C. D., Yuan, X., Venugopal, D., Barany, G., and Allewell, N. M. (1997) Biochem. J. 322, 625-631
4. Morizono, H., Listrom, C. D., Rajagopal, B. S., Aoyagi, M., McCann, M. T., Allewell, N. M., and Tuchman, M. (1997) Hum. Mol. Genet. 6, 963-968
5. Lipscomb, W. N. (1994) Adv. Enzymol. Relat. Areas Mol. Biol. 68, 67-151
6. Tuchman, M., Morizono, H., Reish, O., Yuan, X., and Allewell, N. M. (1995) J. Med. Genet. 32, 680-688
7. Kosman, R. P., Gouaux, J. E., and Lipscomb, W. N. (1993) Proteins Struct. Funct. Genet. 15, 147-176
8. Villeret, V., Tricot, C., Stalon, V., and Dideberg, O. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 10762-10766
9. Jin, L., Seaton, B. A., and Head, J. F. (1997) Nat. Struct. Biol. 4, 622-625
10. Ha, Y., McCann, M. T., Tuchman, M., and Allewell, N. M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 9550-9555
11. Villeret, V., Clantin, B., Tricot, C., Legrain, C., Roovers, M., Stalon, V., Glansdorff, N., and van Beeumen, J. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 2801-2806
12. Otwinoski, Z. (1993) An Oscillation Data Processing Suite for Macromolecular Crystallography. Ph.D. thesis, Yale University, New Haven, CT
13. Navaza, J. (1994) Acta Crystallogr. A 50, 157-163
14. Brünger, A. T. (1996) X-PLOR, version 3.8, Yale University Press, New Haven, CT
15. Jiang, J.-S., and Brünger, A. T. (1994) J. Mol. Biol. 243, 100-115
16. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119
17. Brünger, A. T. (1992) Nature 355, 472-475
18. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Applied Crystallogr. 26, 283-291
19. Collaborative Computer Project, Number 4 (1994) Acta Crystallogr. D 50, 760-763
20. Jahn, O., Sauerstein, J., and Reuter, G. (1987) Arch. Microbiol. 147, 174-178
21. Marshall, M., and Cohen, P. P. (1980) J. Biol. Chem. 255, 7296-7300
22. McDowall, S., van Heeswijck, R., and Hoogenraad, N. (1990) Protein Eng. 4, 73-77