Open-state unblock characterizes acute inhibition of IKs potassium current by amiodarone in guinea pig ventricular myocytes

Journal of Cardiovascular Electrophysiology

Volumn 16, Issue 3, 2005, Pages 314-322

  Zankov, Dimitar P ^a   Ding, Wei Guang ^a   Matsuura, Hiroshi ^a   Horie, Minoru ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

adrenoceptor; Amiodarone; Envelope of tails test; IKs; Isoprenaline; Open channel unblock; phosphorylation; Protein kinase A

Indexed keywords

AMIODARONE; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; NISOLDIPINE; POTASSIUM ION; SODIUM ION;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DELAYED RECTIFIER POTASSIUM CURRENT; DRUG EFFECT; DRUG POTENCY; FEMALE; GUINEA PIG; HEART MUSCLE CELL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; VOLTAGE CLAMP;

ACTION POTENTIALS; AMIODARONE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; FEMALE; GUINEA PIGS; MULTIENZYME COMPLEXES; MYOCARDIUM; MYOCYTES, CARDIAC; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ADRENERGIC, BETA-1; SOLUTIONS;

EID: 15544379698     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1540-8167.2005.40561.x     Document Type: Article

References (48)

1. Charlier R, Delanunois G, Bauthier J, Deltour G: Recherche dans la série des benzofurannes. XL. Propriété anti-arrhythmiques de l'amiodarone. Cardiologia 1969;54:83-89.
2. Dorian P, Mangat I: Role of amiodarone in the era of the implantable cardioverter defibrillator. J Cardiovasc Electrophysiol 2003;14:S78-S81.
3. CASCADE Investigators: Cardiac arrest in Seattle: Conventional versus amiodarone drug evaluation. Am J Cardiol 1991;67:578-584.
4. Julian DG, Camm AJ, Frangin G, Jance MJ, Munoz A, Schwartz PJ, Simon P, for the EMIAT Investigators: Randomized trial of effect of amiodarone on mortality in patients with left ventricular dysfunction after recent myocardial infarction: EMIAT. Lancet 1997;349:667-674.
5. Connolly SJ: Evidence-based analysis of amiodarone efficacy and safety. Circulation 1999;100:2025-2034.
6. Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, Arensberg D, Baker A, Friedman L, Greene HL, Huther ML, Richardson DW. CAST Investigators: Mortality and morbidity in patients receiving encainide, flecainide or placebo: The Cardiac Arrhythmia Suppression Trial. N Engl J Med 1991;324:781-788.
7. Polster P, Broekhuysen J: The adrenergic antagonism of amiodarone. Biochem Pharmacol 1976;25:131-134.
8. Kodama I, Kamiya K, Toyama J: Cellular electropharmacology of amiodarone. Cardiovasc Res 1997;35:13-29.
9. + current: Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 1990;96:195-215.
10. + channels in atrial cells of guinea pig heart. Jpn J Physiol 1990;40:479-490.
11. Wang Z, Fermini B, Nattel S: Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc Res 1994;28:1540-1546.
12. + current in human ventricular myocytes. Circ Res 1996;78:689-696.
13. Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC: A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci USA 2000;97:12329-12333.
14. + current. Circulation 2001;103:1317-1324.
15. Bosch RF, Li G-R, Gaspo R, Nattel S: Electrophysiologic effects of chronic amiodarone therapy and hypothyroidism, alone and in combination, on guinea pig ventricular myocytes. J Pharmacol Exp Ther 1999;289:156-165.
16. Balser JR, Bennett PB, Hondeghem LM, Roden DM: Suppression of time-dependent outward current in guinea pig ventricular myocytes: Actions of quinidine and amiodarone. Circ Res 1991;69:519-529.
17. Yang W-P, Levesque PC, Little WA, Conder ML, Shalaby FY, Blanar MA: KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc Natl Acad Sci USA 1997;94:4017-4021.
18. Ks cardiac potassium current. Nature 1996;384:78-80.
19. Ks potassium channel. Nature 1996;384:80-83.
20. Walsh KB, Kass RS: Regulation of a heart potassium channel by protein kinase A and C. Science 1988;242:67-69.
21. + current in mammalian heart involves G proteins. Am J Physiol 1989;257:H818-H823.
22. Yazawa K, Kameyama M: Mechanism of receptor-mediated modulation of the delayed outward potassium current in guinea-pig ventricular myocytes. J Physiol (Lond) 1990;421:135-150.
23. KS channel complex inhibits drug block: Novel mechanism underlying variable antiarrhythmic drug actions. Circulation 2003;108:132-134.
24. Freedman RA, Swerdlow CD, Echt DS, Wingle RA, Soderholm-Difatte V, Mason JW: Facilitation of ventricular tachyarrhythmia induction by isoproterenol. Am J Cardiol 1984;54:765-770.
25. Noble D, Tsien RW: Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres. J Physiol (Lond) 1969;200:205-231.
26. Powell T, Terrar DA, Twist VW: Electrical properties of individual cells isolated from adult rat ventricular myocardium. J Physiol (Lond) 1980;302:131-153.
27. Isenberg G, Klöckner U: Calcium tolerant ventricular myocytes prepared by preincubation in a "KB medium." Pflügers Arch 1982;395:6-18.
28. Fabiato A, Fabiato F: Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol (Paris) 1979;75:463-505.
29. Tsien RY, Rink TJ: Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium. Biochim Biophys Acta 1980;599:623-638.
30. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 1981;391:85-100.
31. Bénitah J-P, Gomez AM, Bailly P, Da Ponte J-P, Berson G, Delgado C, Lorente P: Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts. J Physiol (Lond) 1993;469:111-138.
32. Heger JJ, Prystowsky EN, Zipes DP: Relationships between amiodarone dosage, drug concentrations, and adverse side effects. Am Heart J 1983;106:931-935.
33. Roden DM: Pharmacokinetics of amiodarone: Implication for drug therapy. Am J Cardiol 1993;72:45F-50F.
34. Nattel S: Pharmacodynamic studies of amiodarone and its active N-desethyl metabolite. J Cardiovasc Pharmacol 1986;8:771-777.
35. Attwell D, Cohen I, Eisner DA: The effects of hear rate on the action potential of guinea-pig and human ventricular muscle. J Physiol (Lond) 1981;313:439-461.
36. KS current shows a time-dependent unblock. J Cardiovasc Pharmacol 2004;43:178-182.
37. Ks) to potassium channel blockers: Implications for clinical reverse use-dependent effects. J Biomed Sci 1999;6:251-259.
38. SK channels expressed in Xenopus oocytes. Biophys J 1998;74:2299-2305.
39. KS blockade at high heart rate in guinea pig and rabbit: Implications for arrhythmogenesis in humans. Circulation 2001;104:951-956.
40. KS contributes to the longer action potential of the M cell. Circ Res 1995;76:351-365.
41. Virág L, Iost N, Opincariu M, Szolnoky J, Szécsi J, Bogáts G, Szenohradszky P, Varró A, Papp JG: The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc Res 2001;49:790-797.
42. Ks) in canine ventricular myocytes. J Physiol (Lond) 2003;551:777-786.
43. Sager PT, Uppal P, Follmer C, Antimisiaris M, Pruitt C, Singh BN: Frequency-dependent electrophysiological effects of amiodarone in humans. Circulation 1993;88:1063-1071.
44. Sager PT, Follmer C, Uppal P, Pruitt C, Godfrey R: The effect of β-adrenergic stimulation on the frequency-dependent electrophysiologic actions of amiodarone and sematilide in humans. Circulation 1994;90:1811-1819.
45. Kr, and effects on myocardial refractoriness for class III antiarrhythmic agents. J Cardiovasc Pharmacol 1995;25:336-340.
46. Sanguinetti MC, Jurkiewicz NK, Scott A, Siegl PKS: Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action. Circ Res 1991;68:77-84.
47. Charlier R: Cardiac actions in the dog of a new antagonist of adrenergic excitation which does not produce competitive blockade of adrenoceptors. Br J Pharmacol 1970;39:668-674.
48. Du XJ, Esler MD, Dart AM: Sympatholytic action of intravenous amiodarone in the rat heart. Circulation 1995;91:462-470.