Alleviation of chronic GVHD in mice by oral immuneregulation toward recipient pretransplant splenocytes does not jeopardize the graft versus leukemia effect

Human Immunology

Volumn 66, Issue 3, 2005, Pages 231-240

  Ilan, Yaron ^a   Margalit, Maya ^a   Ohana, Meir ^b   Gotsman, Israel ^a   Rabbani, Elazar ^c   Engelhardt, Dean ^c   Nagler, Arnon ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c Enzon Incorporated   (United States)

Author keywords

Bone marrow transplantation; Graft versus host disease; Graft versus leukemia; Oral immune regulation

Indexed keywords

BOVINE SERUM ALBUMIN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CELL COUNT; BONE MARROW TRANSPLANTATION; CELL SURVIVAL; CELL TRANSPLANTATION; CHRONIC GRAFT VERSUS HOST DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GRAFT VERSUS LEUKEMIA EFFECT; IMMUNOREGULATION; INOCULATION; LEUKEMIA; LEUKOCYTE COUNT; MALE; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT STRAIN; SPLEEN CELL;

EID: 15444378595     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2004.12.004     Document Type: Article

References (48)

1. J.L.M. Ferrara, H.J. Deeg Graft versus host disease New Engl J Med 324 1991 667
2. G.B. Vogelsang Graft versus host disease implications from basic immunology for prophylaxis and treatment Cancer Treat Res 77 1997 87
3. H.L. Weiner Oral tolerance Proc Natl Acad Sci U S A 91 1994 10762
4. H.L. Weiner Oral tolerance immune mechanisms and treatment of autoimmune diseases Immunol Today 18 1997 335
5. J.M. Benson, S.S. Stuckman, K.L. Cox Oral administration of myelin basic protein is superior to myelin in suppressing established relapsing experimental autoimmune encephalomyelitis J Immunol 162 1999 6247
6. C.H. Ding, Q. Li, Z.Y. Xiong, A.W. Zhou, G. Jones, S.Y. Xu Oral administration of type II collagen suppresses pro-inflammatory mediator production by synoviocytes in rats with adjuvant arthritis Clin Exp Immunol 132 2003 416
7. Y. Ilan, S. Weksler-Zangen, S. Ben-Horin, J. Diment, B. Sauter, E. Rabbani, D. Englehardt, N.R. Chowdhury, J.R. Chowdhury, E. Goldin Treatment of experimental colitis by oral tolerance induction a central role for suppressor lymphocytes Am J Gastroenterol 95 2000 966
8. H.L. Weiner, G.A. Mackin, M. Matsui, E.J. Orav, S.J. Khoury, D.M. Dawson, D.A. Hafler Double blind pilot trial of oral tolerization with myelin antigen in multiple sclerosis Science 261 1993 1321
9. D.E. Trentham, R.A. Dynesius-Trentham, E.J. Orav, D. Combitchi, C. Lorenzo, K. Sewell, D.A. Hafler, H.L. Weiner Effects of oral administration of type II collagen on rheumatoid arthritis Science 261 1993 1727
10. M.G. Von Herrath, T. Dyrberg, M.B.A. Oldstone Oral insulin treatment suppresses virus-induced antigen-specific destruction of β cells and prevents autoimmune diabetes in transgenic mice J Clin Invest 98 1996 1324
11. A. Nagler, M. Pines, U. Abadi, O. Pappo, M. Zeira, D. Engelhardt, E. Rabbani, N.R. Chowdhury, J.R. Chowdhury, Y. Ilan Oral tolerization ameliorates liver disorders associated with chronic graft versus host disease in mice Hepatology 31 2000 641
12. B.D. Jaffe, H.N. Claman Chronic graft versus host disease as a model for scleroderma. Description of a model system Cell Immunol 94 1985 73
13. C.D. Howell, D. De Victor, J. Li, R.C. Giorno Liver T cell subsets and adhesion molecules in murine graft versus host disease Bone Marrow Transplant 16 1995 139
14. C.D. Howell, T.Y. Yoder, J.M. Vierlinng Supperesor function of liver mononuclear cells isolated during chronic graft versus host disease Cell Immunol 140 1992 54
15. Y. Ilan, I. Gotsman, M. Pines, R. Beinart, M. Zeira, M. Ohana, E. Rabbani, D. Engelhardt, A. Nagler Induction of oral tolerance in splenocyte recipients towards pre-transplant antigens ameliorates chronic graft versus host disease in a murine model Blood 95 2000 3613
16. J.F. Apperley, L. Jones, G. Hale, H. Waldmann, J. Hows, Y. Rombos, C. Tsatalas, R.E. Marcus, A.W. Goolden, E.C. Gordon Smith Bone marrow transplantation for patients with chronic myeloid leukaemia T cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapse Bone Marrow Transplant 1 1986 53
17. P.D. Devender, I. Yunis, E.J. Yunis Cellular typing mixed lymphocyte response and cell-mediated lympholysis N.R. Rose H. Friedman J.L. Fahey Manual of clinical laboratory immunology 3rd ed. 1986 American Society for Microbiology Washington, DC 847 852
18. A. Bishara, C. Brautbar, A. Nagler, S. Slavin, B. Leshem, I. Cohen, E. Kedar Prediction by a modified mixed lymphocyte reaction assay of graft versus host disease and graft rejection after allogeneic bone marrow transplantation Transplantation 57 1994 1474
19. J. Mehta Graft-versus-leukemia reactions in clinical bone marrow transplantation Leuk Lymphoma 10 1993 427
20. P.L. Weiden, N. Flournoy, E.D. Thomas, R. Prentice, A. Fefer, C.D. Buckner, R. Storb Antileukemic effect of graft-versus host disease in human recipients of allogeneic-marrow grafts New Engl J Med 300 1979 1068
21. P.L. Weiden, K.M. Sullivan, N. Flournoy, R. Storb, E.D. Thomas Antileukemic effect of chronic graft-versus host disease contribution to improved survival after allogeneic bone marrow transplantation New Engl J Med 304 1981 1529
22. Working Party on Leukaemia, European Group for Bone Marrow Transplantation Allogeneic bone marrow transplantation for leukemia in Europe Lancet i 1988 1379
23. M.M. Horowitz, R.P. Gale, P.M. Sondel, J.M. Goldman, J. Kersey, H.J. Kolb, A.A. Rimm, O. Ringden, C. Rozman, B. Speck Graft-versus-leukemia reactions after bone marrow transplantation Blood 75 1990 555
24. S. Slavin, A. Ackerstein, E. Naparstek, R. Or, L. Weiss The graft-versus-leukemia (GVL) phenomenon is GVL separable from GVHD? Bone Marrow Transplant 6 1990 155
25. K.M. Sullivan, P.L. Weiden, R. Storb, R.P. Witherspoon, A. Fefer, L. Fisher, C.D. Buckner, C. Anasetti, F.R. Appelbaum, C. Badger Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia Blood 73 1989 1720
26. R. Truiit, A. LeFever, C.Y. Shih Graft-versus leukemia reactions experimental models and clinical trials R.P. Gale R.E. Champlain Progress in bone marrow transplantation 1987 Alan R Liss New York 219 232
27. M. Horowitz, R. Gale, P.M. Sondel, J.M. Goldman, J. Kersey, H.J. Kolb, A.A. Rimm, O. Ringden, C. Rozman, B. Speck Graft versus leukemia reactions after bone marrow transplantation Blood 75 1990 555
28. R. Korngold, J. Sprent T cell subsets and graft-versus host disease Transplantation 44 1987 335
29. J. Ohata, J. Sakurai, K. Saito, K. Tani, S. Asano, M. Azuma Differential graft-versus leukemia effect by CD28 and CD40 co-stimulatory blockade after graft-versus-host disease prophylaxis Clin Exp Immunol 129 2002 61
30. J. Baker, M.R. Verneris, M. Ito, J.A. Shizuru, R.S. Negrin Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production Blood 97 2001 2923
31. S.C. Jones, G.F. Murphy, R. Korngold Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response Biol Blood Marrow Transplant 9 2003 243
32. H.L. Weiner Oral tolerance immune mechanisms and generation of Th3-type TGF beta secreting regulatory cells Microbes Infection 3 2001 947
33. Safadi R, Israeli E, Papo O, Shibolet O, Melhem A, Bloch A, Rowe M, Alper R, Klein A, Hemmed N, Segol O, Thalenfeld B, Engelhardt D, Rabbani E, Ilan Y: Treatment of chronic HBV infection via oral immune regulation towards hepatitis B virus proteins. Am J Gastroenterol (in press 2003).
34. I.N. Crispe, T. Dao, K. Klugewitz, W.Z. Mehal, D.P. Metz The liver as a site of T-cell apoptosis graveyard, or killing field? Immunol Rev 174 2000 47
35. R. Champlin, J. Janssen, W. Ho, J. Gajewski, S. Nimer, K. Lee, M. Territo, D. Winston, G. Tricot, T. Reichert Retention of graft-versus-leukemia using selective depletion of CD8-positive T lymphocytes for the prevention of graft-versus-host disease following bone marrow transplantation for chronic myelogenous leukemia Transplant Proc 23 1991 1695
36. A. Shimoni, J.A. Gajewski, M. Donato, T. Martin, S. O'Brien, M. Talpaz, A. Cohen, M. Kornling, R. Champlin, S. Giralt Long-term follow-up of recipients of CD8-depleted donor lymphocyte infusions for the treatment of chronic myelogenous leukemia relapsing after allogeneic progenitor cell transplantation Biol Blood Marrow Transplant 7 2001 568
37. B.R. Dey, Y.G. Yang, G.L. Szot, D.A. Pearson, M. Sykes Interleukin-12 inhibits graft versus host disease through Fas mediated mechanism associated with alterations in T cell activation and expansion Blood 91 1998 3315
38. P. Hoffmann, J. Ermann, M. Eddinger, C.G. Fathman, S. Strober Donor-type CD4+CD25+ regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation J Exp Med 196 2002 389
39. D. Zeng, D. Lewis, S. Dejbakhsh-Jones, F. Lan, M. Garcia-Ojeda, R. Sibley, S. Strober Bone marrow NK1.1- and NK1.1+ T cells reciprocally regulate acute graft versus host disease J Exp Med 189 1999 1073
40. F. Lan, D. Zeng, M. Higuchi, P. Huie, J.P. Higgins, S. Strober Predominance of NK1.1+TCRαβ+ or DX5+ TCRαβ+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease "natural suppressor cells." J Immunol 167 2001 2087
41. J. Cui, T. Shin, T. Kawano, H. Sato, E. Kondo, I. Toura, Y. Kaneko, H. Koseki, M. Kanno, M. Taniguchi Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors Science 278 1997 1623
42. S. Pied, J. Roland, A. Louise, D. Voegtle, V. Soulard, D. Mazier, P.A. Cazenave Liver CD4- CD8- NK1.1+ TCR alpha beta intermediate cells increase during experimental malaria infection and are able to exhibit inhibitory activity against the parasite liver stage in vitro J Immunol 164 2000 1463
43. T. Kadena, G. Matsuzaki, S. Fujise, K. Kishihara, H. Takimoto, M. Sasaki, M. Beppu, S. Nakamura, K. Nomoto TCR α β+ CD4- CD8- T cells differentiate extrathymically in an lck-independent manner and participate in early response against Listeria monocytogenes infection through interferon-γ production Immunology 91 1997 511
44. T. Sumida, A. Sakamoto, H. Murata, Y. Makino, H. Takahashi, S. Yoshida, K. Nishioka, I. Iwamoto, M. Taniguchi Selective reduction of T cells bearing invariant V α 24J α Q antigen receptor in patients with systemic sclerosis J Exp Med 182 1995 1163
45. S.B. Wilson, S.C. Kent, K.T. Patton, T. Orban, R.A. Jackson, M. Exley, S. Porcelli, D.A. Schatz, M.A. Atkinson, S.P. Balk, J.L. Strominger, D.A. Hafler Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes Nature 391 1998 177
46. T. Takahashi, M. Nieda, Y. Kozuka Analysis of human V α 24+ CD4+ NKT cells activated α-glycosylceramide-pulsed monocyte-derived dendritic cells J Immunol 164 2000 4458
47. S. Trop, D. Samsonov, I. Gotsman, R. Alper, J. Diment, Y. Ilan Liver associated lymphocytes expressing NK1.1 are essential for oral tolerance induction in a murine model Hepatology 27 1999 746
48. H. Kitamura, K. Iwakabe, T. Yahata, S. Nishimura, A. Ohta, Y. Ohmi, M. Sato, K. Takeda, K. Okumura, L. Van Kaer, T. Kawano, M. Taniguchi, T. Nishimura The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin-12 production by dendritic cells and IL-12 receptor expression on NKT cells J Exp Med 189 1999 1121