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Volumn 20, Issue 1-2, 1999, Pages 11-17

Activation of the inflammatory response system: A new look at the etiopathogenesis of major depression

Author keywords

Cytokines; Depression; Psychiatry; Psychoneuroimmunology

Indexed keywords

ANTIDEPRESSANT AGENT; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 6; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TRYPTOPHAN; ZINC;

EID: 0032753366     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (73)

References (61)
  • 1
    • 0022374305 scopus 로고
    • Sex hormones, immune responses, and autoimmune diseases
    • Ahmed SA, Penhale WJ, Talal N (1985) Sex hormones, immune responses, and autoimmune diseases. Am J Pathol 21: 531-551
    • (1985) Am J Pathol , vol.21 , pp. 531-551
    • Ahmed, S.A.1    Penhale, W.J.2    Talal, N.3
  • 2
    • 0031964955 scopus 로고    scopus 로고
    • Differential effects of interleukin (IL)-1beta, IL-2 and IL-6 on responding for rewarding lateral hypothalamic stimulation
    • Anisman H, Kokkinidis L, Borowski T, Merali Z (1998) Differential effects of interleukin (IL)-1beta, IL-2 and IL-6 on responding for rewarding lateral hypothalamic stimulation. Brain Res 779: 177-187
    • (1998) Brain Res , vol.779 , pp. 177-187
    • Anisman, H.1    Kokkinidis, L.2    Borowski, T.3    Merali, Z.4
  • 4
    • 0032498325 scopus 로고    scopus 로고
    • Depression, stress and immunological activation: The role of cytokines in depressive disorders
    • Connor TJ, Leonard BE (1998) Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Sci 62: 583-606
    • (1998) Life Sci , vol.62 , pp. 583-606
    • Connor, T.J.1    Leonard, B.E.2
  • 5
    • 0023755124 scopus 로고
    • Tissue-specific regulation of zinc metabolism and metallothionein genes by interleukin-1
    • Cousins RJ, Leinart AS (1988) Tissue-specific regulation of zinc metabolism and metallothionein genes by interleukin-1. FASEB J 2: 2884-2890
    • (1988) FASEB J , vol.2 , pp. 2884-2890
    • Cousins, R.J.1    Leinart, A.S.2
  • 8
  • 9
    • 0023254649 scopus 로고
    • Interleukin 1-induced depression of iron and zinc: Role of granulocytesand lactoferrin
    • Goldblum SE, Cohen DA, Jay M, McClain CJ (1987) Interleukin 1-induced depression of iron and zinc: role of granulocytesand lactoferrin. Am J Physiol 252: 27-32
    • (1987) Am J Physiol , vol.252 , pp. 27-32
    • Goldblum, S.E.1    Cohen, D.A.2    Jay, M.3    McClain, C.J.4
  • 13
    • 0020000298 scopus 로고
    • The phenomenon of the acute phase response
    • Kushner I (1982) The phenomenon of the acute phase response. Ann NY Sci 389: 39-48
    • (1982) Ann NY Sci , vol.389 , pp. 39-48
    • Kushner, I.1
  • 14
    • 0032078993 scopus 로고    scopus 로고
    • Brain neurotransmission during peripheral inflammation
    • Linthorst AC, Reul JM (1998) Brain neurotransmission during peripheral inflammation. Ann NY Acad Sci 840: 139-152
    • (1998) Ann NY Acad Sci , vol.840 , pp. 139-152
    • Linthorst, A.C.1    Reul, J.M.2
  • 15
    • 0027722985 scopus 로고
    • Acute phase protein alterations in major depression: A review
    • Maes M (1993) Acute phase protein alterations in major depression: A review. Rev Neurosci 4: 407-416
    • (1993) Rev Neurosci , vol.4 , pp. 407-416
    • Maes, M.1
  • 16
    • 0028796205 scopus 로고
    • The interleukin hypothesis of major depression
    • Maes M (1995) The Interleukin hypothesis of major depression. Prog Neuro-Psychopharmacol Biol Psychiat 19: 11-38
    • (1995) Prog Neuro-Psychopharmacol Biol Psychiat , vol.19 , pp. 11-38
    • Maes, M.1
  • 17
    • 0002751555 scopus 로고    scopus 로고
    • The immune pathophysiology of major depression
    • Honig A, van Praag HM (eds) John Wiley, London
    • Maes M (1997) The immune pathophysiology of major depression. In: Honig A, van Praag HM (eds) Depression: Neurobiological, Psychopathological and Therapeutic Advances. John Wiley, London, pp 197-215
    • (1997) Depression: Neurobiological, Psychopathological and Therapeutic Advances , pp. 197-215
    • Maes, M.1
  • 18
    • 0000587671 scopus 로고
    • The serotonin hypothesis of major depression
    • Bloom F, Kupher D (eds) Raven Press, New York
    • Maes M, Meltzer HY (1995) The serotonin hypothesis of major depression. In: Bloom F, Kupher D (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 933-944
    • (1995) Psychopharmacology: the Fourth Generation of Progress , pp. 933-944
    • Maes, M.1    Meltzer, H.Y.2
  • 20
    • 0006059281 scopus 로고    scopus 로고
    • Editorial: Fatty acids, cytokines and major depression
    • Maes M, Smith RS (1998) Editorial: Fatty acids, cytokines and major depression. Biol Psychiat 43: 314-319
    • (1998) Biol Psychiat , vol.43 , pp. 314-319
    • Maes, M.1    Smith, R.S.2
  • 21
    • 0025943357 scopus 로고
    • Depression-related disturbances in mitogen-induced lymphocyte responses, interleukin-1ß, and soluble interleukin-2-receptor production
    • Maes M, Bosmans E, Suy E, Vandervorst C, Dejonckheere C, Minner B, Raus J (1991a) Depression-related disturbances in mitogen-induced lymphocyte responses, interleukin-1ß, and soluble interleukin-2-receptor production. Acta Psychiat Scand 84: 379-386
    • (1991) Acta Psychiat Scand , vol.84 , pp. 379-386
    • Maes, M.1    Bosmans, E.2    Suy, E.3    Vandervorst, C.4    Dejonckheere, C.5    Minner, B.6    Raus, J.7
  • 22
    • 0025808096 scopus 로고
    • Anthropometric and biochemical assessment of the nutritional state in depression: Evidence for lower visceral protein plasma levels in depression
    • Maes M, Vandewoude M, Scharpé S, De Clerck L, Stevens W, Lepoutre L, Schotte C (1991b) Anthropometric and biochemical assessment of the nutritional state in depression: evidence for lower visceral protein plasma levels in depression. J Affect Disord 23: 25-33
    • (1991) J Affect Disord , vol.23 , pp. 25-33
    • Maes, M.1    Vandewoude, M.2    Scharpé, S.3    De Clerck, L.4    Stevens, W.5    Lepoutre, L.6    Schotte, C.7
  • 23
    • 0026519357 scopus 로고
    • Evidence for a systemic immune activation during depression: Results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining
    • Maes M, Lambrechts J, Bosmans E, Jacobs J, Suy E, Vandervorst C, De Jonckheere C, Minner B, Raus J (1992a) Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining. Psychol Med 22: 45-53
    • (1992) Psychol Med , vol.22 , pp. 45-53
    • Maes, M.1    Lambrechts, J.2    Bosmans, E.3    Jacobs, J.4    Suy, E.5    Vandervorst, C.6    De Jonckheere, C.7    Minner, B.8    Raus, J.9
  • 25
    • 0026552955 scopus 로고
    • Higher α1-antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding protein plasma levels during depression: Further evidence for the existence of an inflammatory response during that illness
    • Maes M, Scharpé S, Van Grootel L, Uyttenbroeck W, Cooreman W, Cosyns P, Suy E (1992c) Higher α1-antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding protein plasma levels during depression: further evidence for the existence of an inflammatory response during that illness. J Affect Disord 24 183-192
    • (1992) J Affect Disord , vol.24 , pp. 183-192
    • Maes, M.1    Scharpé, S.2    Van Grootel, L.3    Uyttenbroeck, W.4    Cooreman, W.5    Cosyns, P.6    Suy, E.7
  • 26
    • 0027182417 scopus 로고
    • Interleukin-1ß: A putative mediator of HPA-axis hyperactivity in major depression?
    • Maes M, Bosmans E, Meltzer HY, Scharpe S, Suy E (1993a) Interleukin-1ß: A putative mediator of HPA-axis hyperactivity in major depression? Am J Psychiat 150: 1189-1193
    • (1993) Am J Psychiat 1 , vol.50 , pp. 1189-1193
    • Maes, M.1    Bosmans, E.2    Meltzer, H.Y.3    Scharpe, S.4    Suy, E.5
  • 27
    • 0027241497 scopus 로고
    • Psychomotor retardation, anorexia, weight loss, sleep disturbances and loss of energy: Psychopathological correlates of hyperhaptoglobinemia during major depression
    • Maes M, Meltzer HY, Scharpé S, Uyttenbroeck W, Cooremans W, Suy E (1993b) Psychomotor retardation, anorexia, weight loss, sleep disturbances and loss of energy: psychopathological correlates of hyperhaptoglobinemia during major depression. Psychiat Res 47: 229-241
    • (1993) Psychiat Res , vol.47 , pp. 229-241
    • Maes, M.1    Meltzer, H.Y.2    Scharpé, S.3    Uyttenbroeck, W.4    Cooremans, W.5    Suy, E.6
  • 29
    • 0027496577 scopus 로고
    • Relationships between increased haptoglobin plasma levels and activity of cell-mediated immunity
    • Maes M, Scharpé S, Meltzer HY, Cosyns P (1993d) Relationships between increased haptoglobin plasma levels and activity of cell-mediated immunity. Biol Psychiat 34: 690-701
    • (1993) Biol Psychiat , vol.34 , pp. 690-701
    • Maes, M.1    Scharpé, S.2    Meltzer, H.Y.3    Cosyns, P.4
  • 31
    • 0028278156 scopus 로고
    • Relationships between basal hypothalamic-pituitary-thyroid axis activity and plasma haptoglobin levels in depression
    • Maes M, Scharpe S, Cosyns P, Meltzer HY (1994b) Relationships between basal hypothalamic-pituitary-thyroid axis activity and plasma haptoglobin levels in depression. J Psychiat Res 28: 123-134
    • (1994) J Psychiat Res , vol.28 , pp. 123-134
    • Maes, M.1    Scharpe, S.2    Cosyns, P.3    Meltzer, H.Y.4
  • 33
    • 0028670087 scopus 로고
    • Increased neopterin and interferon gamma secretion and lower L-tryptophan levels in major depression: Further evidence for immune activation in severe depression
    • Maes M, Scharpe S, Meltzer HY, Okayli G, D'Hondt P, Cosyns P (1994d) Increased neopterin and interferon gamma secretion and lower L-tryptophan levels in major depression: further evidence for immune activation in severe depression. Psychiat Res 54: 143-160
    • (1994) Psychiat Res , vol.54 , pp. 143-160
    • Maes, M.1    Scharpe, S.2    Meltzer, H.Y.3    Okayli, G.4    D'Hondt, P.5    Cosyns, P.6
  • 34
    • 0029146932 scopus 로고
    • Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression
    • Maes M, Meltzer HY, Bosmans E, Bergmans R, Vandoolaeghe E, Ranjan R, Desnyder R (1995a) Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression. J Affect Disord 34: 301-309
    • (1995) J Affect Disord , vol.34 , pp. 301-309
    • Maes, M.1    Meltzer, H.Y.2    Bosmans, E.3    Bergmans, R.4    Vandoolaeghe, E.5    Ranjan, R.6    Desnyder, R.7
  • 36
    • 0029973068 scopus 로고    scopus 로고
    • Fatty acid composition in major depression: Decreased ω3 fractions in cholesteryl esters and increased C20:4ω6/C20:5ω3 ratio in cholesteryl esters and phospholipids
    • Maes M, Smith R, Christophe A, Cosyns P, Desnyder R, Meltzer HY (1996a) Fatty acid composition in major depression: decreased ω3 fractions in cholesteryl esters and increased C20:4ω6/C20:5ω3 ratio in cholesteryl esters and phospholipids. J Affect Disord 38: 35-46
    • (1996) J Affect Disord , vol.38 , pp. 35-46
    • Maes, M.1    Smith, R.2    Christophe, A.3    Cosyns, P.4    Desnyder, R.5    Meltzer, H.Y.6
  • 37
    • 0030576911 scopus 로고    scopus 로고
    • Alterations in iron metabolism and the erythron in major depression: Further evidence for a chronic inflammatory process
    • Maes M, Van de Vyvere J, Vandoolaeghe E, Bril T, Demedts P, Wauters A, Neels H (1996b) Alterations in iron metabolism and the erythron in major depression: further evidence for a chronic inflammatory process. J Affect Disord 40: 23-33
    • (1996) J Affect Disord , vol.40 , pp. 23-33
    • Maes, M.1    Van De Vyvere, J.2    Vandoolaeghe, E.3    Bril, T.4    Demedts, P.5    Wauters, A.6    Neels, H.7
  • 38
    • 0031282469 scopus 로고    scopus 로고
    • Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression
    • Maes M, Bosmans E, De Jongh R, Kenis G, Vandoolaeghe E, Neels H (1997a) Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. Cytokine 9: 853-858
    • (1997) Cytokine , vol.9 , pp. 853-858
    • Maes, M.1    Bosmans, E.2    De Jongh, R.3    Kenis, G.4    Vandoolaeghe, E.5    Neels, H.6
  • 39
    • 0031568313 scopus 로고    scopus 로고
    • The acute phase protein response in schizophrenia, mania and major depression: Effects of psychotropic drugs
    • Maes M, Delanghe J, Ranjan R, Meltzer HY, Desnyder R, Cooreman W, Scharpe S (1997b) The acute phase protein response in schizophrenia, mania and major depression: effects of psychotropic drugs. Psychiat Res 66: 1-11
    • (1997) Psychiat Res , vol.66 , pp. 1-11
    • Maes, M.1    Delanghe, J.2    Ranjan, R.3    Meltzer, H.Y.4    Desnyder, R.5    Cooreman, W.6    Scharpe, S.7
  • 40
    • 0030880731 scopus 로고    scopus 로고
    • Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness
    • Maes M, Vandoolaeghe E, Neels H, Demedts P, Wauters A, Meltzer HY, Altamura C, Desnyder R (1997c) Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness. Biol Psychiat 42: 349-358
    • (1997) Biol Psychiat , vol.42 , pp. 349-358
    • Maes, M.1    Vandoolaeghe, E.2    Neels, H.3    Demedts, P.4    Wauters, A.5    Meltzer, H.Y.6    Altamura, C.7    Desnyder, R.8
  • 42
    • 0006057278 scopus 로고    scopus 로고
    • Negative immunoregulatory effects of antidepressants: Increased production of interleukin-10 and suppressed production of interferon-gamma
    • accepted
    • Maes M, Song C, Lin A, Bonaccorso S, Scharpe S, Kenis G, DeJongh R, Bosmans E, Scharpe S (1998a) Negative immunoregulatory effects of antidepressants: increased production of interleukin-10 and suppressed production of interferon-gamma. Neuropsychopharmacol, accepted
    • (1998) Neuropsychopharmacol
    • Maes, M.1    Song, C.2    Lin, A.3    Bonaccorso, S.4    Scharpe, S.5    Kenis, G.6    DeJongh, R.7    Bosmans, E.8    Scharpe, S.9
  • 43
    • 0003137853 scopus 로고    scopus 로고
    • Immune and clinical correlates of psychological stress-induced production of interferon-γ and IL-10 in humans
    • Plotnikoff NP, Faith RE, Murgo AJ, Good RA (eds) Boca Raton: CRC-Press
    • Maes M, Song C, Lin A, DeJongh R, Kenis G, Bosmans E, DeMeester I, Neels H, Scharpe S (1998b) Immune and clinical correlates of psychological stress-induced production of interferon-γ and IL-10 in humans. In: Plotnikoff NP, Faith RE, Murgo AJ, Good RA (eds) Cytokines, Stress and Immunity. Boca Raton: CRC-Press, pp 39-50
    • (1998) Cytokines, Stress and Immunity , pp. 39-50
    • Maes, M.1    Song, C.2    Lin, A.3    DeJongh, R.4    Kenis, G.5    Bosmans, E.6    DeMeester, I.7    Neels, H.8    Scharpe, S.9
  • 45
    • 0028846024 scopus 로고
    • Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock
    • Maier SF, Watkins LR (1995) Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock. Brain Res 695: 279-282
    • (1995) Brain Res , vol.695 , pp. 279-282
    • Maier, S.F.1    Watkins, L.R.2
  • 46
    • 0031600021 scopus 로고    scopus 로고
    • Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition
    • Maier SF, Watkins LR (1998) Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev 105: 83-107
    • (1998) Psychol Rev , vol.105 , pp. 83-107
    • Maier, S.F.1    Watkins, L.R.2
  • 47
    • 0003024193 scopus 로고
    • Tricyclic antidepressants and immunity
    • Miller H (ed) American Psychiatric Press, Washington DC
    • Miller AH, Lackner C (1989) Tricyclic antidepressants and immunity. In: Miller H (ed) Depressive Disorders and Immunity. American Psychiatric Press, Washington DC, pp 85-104
    • (1989) Depressive Disorders and Immunity , pp. 85-104
    • Miller, A.H.1    Lackner, C.2
  • 49
    • 0026081754 scopus 로고
    • Interleukins-1 and -6 stimulate the release of corticotropin-releasing hormone 41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway
    • Navarra P, Tsagarakis S, Faria MS, Rees LH, Besser GM, Grossman AB (1991) Interleukins-1 and -6 stimulate the release of corticotropin-releasing hormone 41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway. Endocrinol 128: 37-44
    • (1991) Endocrinol , vol.128 , pp. 37-44
    • Navarra, P.1    Tsagarakis, S.2    Faria, M.S.3    Rees, L.H.4    Besser, G.M.5    Grossman, A.B.6
  • 50
    • 0023276493 scopus 로고
    • Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
    • Sapolsky R, Rivier C, Yamamoto G (1987) Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Sci 238: 522-524
    • (1987) Sci , vol.238 , pp. 522-524
    • Sapolsky, R.1    Rivier, C.2    Yamamoto, G.3
  • 54
    • 0030575355 scopus 로고    scopus 로고
    • Concentration and microheterogenecity forms of alpha-1-acid glycoprotein in major depressed disorder
    • Sluzewska A, Rybakowski J, Sobieska M, Wiktorowicz K (1996b) Concentration and microheterogenecity forms of alpha-1-acid glycoprotein in major depressed disorder. J Affect Disord
    • (1996) J Affect Disord
    • Sluzewska, A.1    Rybakowski, J.2    Sobieska, M.3    Wiktorowicz, K.4
  • 55
    • 0002040853 scopus 로고
    • Zinc and copper
    • Shils ME and Youg VR (eds) Lea and Febiger, Philadelphia
    • Solomons NW (1988) Zinc and copper. In: Shils ME and Youg VR (eds) Modern Nutrition in Health and Disease. Lea and Febiger, Philadelphia, pp 238-262
    • (1988) Modern Nutrition in Health and Disease , pp. 238-262
    • Solomons, N.W.1
  • 56
    • 0028258379 scopus 로고
    • Changes in immuno-globulin, complement and acute phase protein levels in the depressed patients and normal controls
    • Song C, Dinan T, Leonard BE (1994) Changes in immuno-globulin, complement and acute phase protein levels in the depressed patients and normal controls. J Affect Disord 30: 283-288
    • (1994) J Affect Disord , vol.30 , pp. 283-288
    • Song, C.1    Dinan, T.2    Leonard, B.E.3
  • 58
    • 0025281273 scopus 로고
    • Albumin decrement in depression and cholesterol decrement in mania
    • Swartz CM (1990) Albumin decrement in depression and cholesterol decrement in mania. J Affect Disord 19: 173-176
    • (1990) J Affect Disord , vol.19 , pp. 173-176
    • Swartz, C.M.1
  • 59
    • 0006022387 scopus 로고    scopus 로고
    • Lower number of red blood cells, hematocrit and hemoglobin in major depression: Effects of antidepressants
    • accepted
    • Vandoolaeghe E, DeVos N, DeSchouwer P, Neels H, Maes M. (1999) Lower number of red blood cells, hematocrit and hemoglobin in major depression: effects of antidepressants. Hum Psychopharmacol, accepted
    • (1999) Hum Psychopharmacol
    • Vandoolaeghe, E.1    DeVos, N.2    DeSchouwer, P.3    Neels, H.4    Maes, M.5
  • 60
    • 0002437146 scopus 로고
    • Sex differences in susceptibility to infections
    • Washburn TC, Medearis J, Childs B (1965) Sex differences in susceptibility to infections. Ped 35: 57-64
    • (1965) Ped , vol.35 , pp. 57-64
    • Washburn, T.C.1    Medearis, J.2    Childs, B.3
  • 61
    • 0030220185 scopus 로고    scopus 로고
    • Tricyclic antidepressants inhibit IL-6, IL-1ß and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells
    • Xia Z, DePierre JW, Nassberger L (1996) Tricyclic antidepressants inhibit IL-6, IL-1ß and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells. Immunopharmacol 34: 27-37
    • (1996) Immunopharmacol , vol.34 , pp. 27-37
    • Xia, Z.1    DePierre, J.W.2    Nassberger, L.3


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