The induction of gene mutations and micronuclei by oxiranes and siloranes in mammalian cells in vitro

Journal of Dental Research

Volumn 83, Issue 1, 2004, Pages 17-21

  Schweikl, H ^a   Schmalz, G ^a   Weinmann, W ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b 3M Deutschland GmbH   (Germany)

Author keywords

Micronucleus test; Mutagenicity; Oxirane; Silorane; V79 HPRT

Indexed keywords

2,2 BIS(4 GLYCIDYLOXYPHENYL)PROPANE; 2,2-BIS(4-GLYCIDYLOXYPHENYL)PROPANE; BIOMEDICAL AND DENTAL MATERIALS; CARCINOGEN; CYCLOHEXANE DERIVATIVE; DI (3,4 EPOXYCYCLOHEXYLMETHYL)DIMETHYLSILANE; DI-(3,4-EPOXYCYCLOHEXYLMETHYL)DIMETHYLSILANE; EPOXIDE; EPOXY CYCLOHEXYL METHYL EPOXY CYCLO HEXANE CARBOXYLATE; EPOXY CYCLOHEXYL METHYL-EPOXY CYCLO-HEXANE CARBOXYLATE; ETHYLENE OXIDE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIVER EXTRACT; SILANE DERIVATIVE;

ANIMAL; ARTICLE; CELL LINE; CHROMOSOME ABERRATION; CRICETULUS; DRUG EFFECT; FIBROBLAST; GENETICS; HAMSTER; MICRONUCLEUS; MUTATION; RAT;

ANIMALS; CARCINOGENS; CELL LINE; CHROMOSOME ABERRATIONS; CRICETINAE; CRICETULUS; CYCLOHEXANES; DENTAL MATERIALS; EPOXY COMPOUNDS; ETHYLENE OXIDE; FIBROBLASTS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIVER EXTRACTS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTATION; RATS; SILANES;

EID: 1542652359     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910408300104     Document Type: Article

References (24)

1. Bentley P, Staubli W, Bieri F, Muecke W, Waechter F (1985). Induction of hepatic drug-metabolising enzymes following treatment of rats and mice with chlordimeform. Toxicol Lett 28:143-149.
2. Bradley MO, Bhuyan B, Francis MC, Langenbach R, Peterson A, Huberman E (1981). Mutagenesis by chemical agents in V79 Chinese hamster cells: a review and analysis of the literature. A report of the Gene-Tox Program. Mutat Res 87:81-142.
3. Ehrenberg L, Hussain S (1981). Genetic toxicity of some important epoxides. Mutat Res 86:1-113.
4. Eick JD, Kostoryz EL, Rozzi SM, Jacobs DW, Oxman JD, Chappelow CC, et al. (2002). In vitro biocompatibility of oxirane/polyol dental composites with promising physical properties. Dent Mater 18:413-421.
5. Geurtsen W (2000). Biocompatibility of resin-modified filling materials. Crit Rev Oral Biol Med 11:333-355.
6. Glatt H (1994). Comparison of common gene mutation tests in mammalian cells in culture: a position paper of the GUM Commission for the Development of Guidelines for Genotoxicity Testing. Mutat Res 313:7-20.
7. Hanks CT, Strawn SE, Wataha JC, Craig RG (1991). Cytotoxic effects of resin components on cultured mammalian fibroblasts. J Dent Res 70:1450-1455.
8. International Organization for Standardization (1992). ISO 10993-3: tests for genotoxicity, carcinogenicity and reproductive toxicity. Geneva.
9. Kostoryz EL, Tong PY, Chappelow CC, Eick JD, Glaros AG, Yourtee DM (1999). In vitro cytotoxicity of solid epoxy-based dental resins and their components. Dent Mater 15:363-373.
10. Miller B, Albertini S, Locher F, Thybaud V, Lorge E (1997). Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience. Mutat Res 392:45-59.
11. Pelka M, Distler W, Petschelt A (1999). Elution parameters and HPLC-detection of single components from resin composite. Clin Oral Investig 3:194-200.
12. Recio L, Steen AM, Pluta LJ, Meyer KG, Saranko CJ (2001). Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms. Chem Biol Interact 135-136:325-341.
13. Schmalz G (1998). The biocompatibility of non-amalgam dental filling materials. Eur J Oral Sci 106:696-706.
14. Schweikl H, Schmalz G, Rackebrandt K (1998). The mutagenic activity of unpolymerized resin monomers in Salmonella typhimurium and V79 cells. Mutat Res 415:119-130.
15. Schweikl H, Schmalz G, Spruss T (2001). The induction of micronuclei in vitro by unpolymerized resin monomers. J Dent Res 80:1615-1620.
16. Schweikl H, Schmalz G, Weinmann W (2002). Mutagenic activity of structurally related oxiranes and siloranes in Salmonella typhimurium. Mutat Res 521:19-27.
17. Seiler JP (1984). The mutagenicity of mono- and di-functional aromatic glycidyl compounds. Mutat Res 135:159-167.
18. Sinsheimer JE, Chen R, Das SK, Hooberman BH, Osorio S, You Z (1993). The genotoxicity of enantiomeric aliphatic epoxides. Mutat Res 298:197-206.
19. Steen AM, Meyer KG, Recio L (1997). Analysis of hprt mutations occurring in human TK6 lymphoblastoid cells following exposure to 1,2,3,4-diepoxybutane. Mutagenesis 12:61-67.
20. Sueiro RA, Araujo M, Suarez S, Garrido MJ (2001). Mutagenic potential of bisphenol A diglycidyl ether (BADGE) and its hydrolysis-derived products in the Ames Salmonella assay. Mutagenesis 16:303-307.
21. Tilbrook DA, Clarke RL, Howle NE, Braden M (2000). Photocurable epoxy-polyol matrices for use in dental composites I. Biomaterials 21:1743-1753.
22. von der Hude W, Kalweit S, Engelhardt G, McKiernan S, Kasper P, Slacik-Erben R, et al. (2000). In vitro micronucleus assay with Chinese hamster V79 cells - results of a collaborative study with in situ exposure to 26 chemical substances. Mutat Res 468:137-163.
23. Waters MD, Stack HF, Jackson MA (1999). Short-term tests for defining mutagenic carcinogens. IARC Sci Publ 146:499-536.
24. Yourtee D, Holder AJ, Smith R, Morrill JA, Kostoryz E, Brockmann W, et al. (2001). Quantum mechanical quantitative structure activity relationships to avoid mutagenicity in dental monomers. J Biomater Sci Polym Ed 12:89-105.