Optimizing Storage Stability of Lyophilized Recombinant Human Interleukin-11 with Disaccharide/Hydroxyethyl Starch Mixtures

Journal of Pharmaceutical Sciences

Volumn 93, Issue 3, 2004, Pages 684-696

  Garzon Rodriguez, William ^a   Koval, Rebecca L ^b   Chongprasert, Suchart ^a   Krishnan, Sampathkumar ^a   Randolph, Theodore W ^c   Warne, Nicholas W ^b   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b PFIZER INC   (United States)

^c UCB 450   (United States)

Author keywords

Glass transition; Infrared spectroscopy; Interleukin 11; Oxidation; Protein aggregation; Proteins; Stability

Indexed keywords

DISACCHARIDE; HETASTARCH; RECOMBINANT INTERLEUKIN 11; STARCH; SUCROSE; TREHALOSE;

ARTICLE; CARBOHYDRATE ANALYSIS; CYTOKINE PRODUCTION; DRUG FORMULATION; DRUG MIXTURE; DRUG STABILITY; DRUG STORAGE; FREEZE DRYING; GEL PERMEATION CHROMATOGRAPHY; GLASS TRANSITION TEMPERATURE; INFRARED SPECTROSCOPY; LYOPHILISATE; OXIDATION KINETICS; POLYMERIZATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; QUANTITATIVE DIAGNOSIS; REACTION ANALYSIS; REACTION OPTIMIZATION; REHYDRATION; REVERSED PHASE LIQUID CHROMATOGRAPHY; TEMPERATURE DEPENDENCE;

EID: 1542619712     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10587     Document Type: Article

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