The synthesis and structure-activity relationships of 3-amino-4- benzylquinolin-2-ones: Discovery of novel KCNQ2 channel openers

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 7, 2004, Pages 1615-1618

  Hewawasam, Piyasena ^a   Chen, Nathan ^a   Ding, Min ^a   Natale, Joanne T ^a   Boissard, Christopher G ^a   Yeola, Sarita ^a   Gribkoff, Valentin K ^a   Starrett, John ^a   Dworetzky, Steven I ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL STIMULATING AGENT; QUINOLINE DERIVATIVE;

ANIMAL CELL; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; EVALUATION; MOLECULAR CLONING; NONHUMAN; OOCYST; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ANIMALS; FEMALE; ION CHANNEL GATING; KCNQ2 POTASSIUM CHANNEL; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 1542613876     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.073     Document Type: Article

References (20)

1. Shieh C.C., Coghlan M., Sullivan J.P., Gopalakrishnan M. Pharmacol. Rev. 52:2000;557.
2. Coghlan M.J., Carroll W.A., Gopalakrishnan M. J. Med. Chem. 44:2001;1627.
3. Jentsch T.J. Nat. Rev. Neurosci. 1:2000;21.
4. Robbins J. Pharmacol. Ther. 90:2001;1.
5. Wang Q., Curran M.E., Splawski I., Burn T.C., Millholland J.M., VanRaay T.J., Shen J., Timothy K.W., Vincent G.M., de Jager T., Schwartz P.J., Toubin J.A., Moss A.J., Atkinson D.L., Landes G.M., Connors T.D., Keating M.T. Nat. Genet. 12:1996;17.
6. Biervert C., Schroeder B.C., Kubisch C., Berkovic S.F., Propping P., Jentsch T.J., Steinlein O.K. Science. 279:1998;403.
7. Kubisch C., Schroeder B.C., Friedrich T., Lutjohann B., El-Amraoui A., Marlin S., Petit C., Jentsch T.J. Cell. 96:1999;437.
8. Yang W.P., Levesque P.C., Little W.A., Conder M.L., Shalaby F.Y., Blanar M.A. Proc. Natl. Acad. Sci. 94:1997;4017.
9. Tinel N., Lauritzen I., Chouabe C., Lazdunski M., Borsotto M. FEBS Lett. 438:1998;171.
10. Wang H.S., Pan Z., Shi W., Brown B.S., Wymore R.S., Cohen I.S., Dixon J.E., McKinnon D. Science. 282:1998;1890.
11. Charlier C., Singh N.A., Ryan S.G., Lewis T.B., Reus B.E., Leach R.J., Leppert M. Nat. Genet. 18:1998;53.
12. Singh N.A., Charlier C., Stauffer D., DuPont B.R., Leach R.J., Melis R., Ronen G.M., Bjerre I., Quattlebaum T., Murphy J.V., McHarg M.L., Gagnon D., Rosales T.O., Peiffer A., Anderson V.E., Leppert M. Nat. Genet. 18:1998;25.
13. Wickenden, A. D.; Rigdon, G. C.; McNaughton-Smith, G. A.; Gross, M. F. WO Patent 0,110,381 2001.
14. Blackburn-Munro G., Jensen B.S. Eur. J. Pharmacol. 460:2003;109.
15. Main M.J., Cryan J.E., Dupere J.R., Cox B., Clare J.J., Burbidge S.A. Mol. Pharmacol. 58:2000;253.
16. McNaughton-Smith, G. A.; Gross, M. F.; Wickenden, A. D. US Patent 6,372,767 2002.
17. Hewawasam P., Fan W., Knipe J., Moon S.L., Boissard C.G., Gribkoff V.K., Starrett J.E. Jr. Bioorg. Med. Chem. Lett. 12:2002;1779.
18. Muchowski J.M., Venuti M.C. J. Org. Chem. 45:1980;4798.
19. Takagishi S., Katsoulos G., Schlosser M. Synlett. 1991;360.
20. Stuhmer W. Methods Enzymol. 207:1992;319.