17β-Estradiol Downregulates β3-Integrin Expression in Differentiating and Mature Human Osteoclasts

Journal of Cellular Physiology

Volumn 198, Issue 2, 2004, Pages 269-276

  Saintier, D ^a   Burde, M A ^a   Rey, J M ^b   Maudelonde, T ^b   De Vernejoul, M C ^a   Cohen Solal, M E ^a,c  

^a HÔPITAL LARIBOISIÈRE   (France)

^b HÔPITAL ARNAUD DE VILLENEUVE   (France)

^c CENTRE VIGGO PETERSEN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; BETA5 INTEGRIN; COLONY STIMULATING FACTOR 1; ESTRADIOL; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; RALOXIFENE; ANTIESTROGEN; PROTEIN C FOS; PROTEIN C JUN;

ARTICLE; CELL ADHESION; CELL FATE; CELL MATURATION; HUMAN; HUMAN CELL; OSTEOCLAST; OSTEOLYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BIOSYNTHESIS; BONE; CELL DIFFERENTIATION; COMPARATIVE STUDY; DOWN REGULATION; DRUG EFFECT; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; TIME; WESTERN BLOTTING;

BLOTTING, WESTERN; BONE AND BONES; BONE RESORPTION; CELL DIFFERENTIATION; DOWN-REGULATION; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INTEGRIN BETA3; ORGAN CULTURE TECHNIQUES; OSTEOCLASTS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RALOXIFENE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

EID: 1542574586     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10406     Document Type: Article

References (28)

1. Arts J, Kuiper GG, Janssen JM, Gustafsson JA, Lowik CW, Pols HA, van Leeuwen JP. 1997. Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138:5067-5070.
2. Braidman IP, Davenport LK, Carter DH, Selby PL, Mawer EB, Freemont AJ. 1995. Preliminary in situ identification of estrogen target cells in bone. J Bone Miner Res 10:74-80.
3. Brubaker KD, Gay CV. 1999. Estrogen stimulates protein tyrosine phosphorylation and Src kinase activity in avian osteoclasts. J Cell Biochem 76:206-216.
4. De Nichilo MO, Burns GF. 1993. Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages. Proc Natl Acad Sci USA 90:2517-2521.
5. Duong LT, Rodan GA. 1998. Integrin-mediated signaling in the regulation of osteoclast adhesion and activation. Front Biosci 3:d757-d768.
6. Duong LT, Rodan GA. 2001. Regulation of osteoclast formation and function. Rev Endocr Metab Disord 2:95-104.
7. Engleman VW, Nickols GA, Ross FP, Horton MA, Griggs DW, Settle SL, Ruminski PG, Teitelbaum SL. 1997. A peptidomimetic antagonist of the alpha v beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. J Clin Invest 99:2284-2292.
8. Fujikawa Y, Sabokbar A, Neale SD, Itonaga I, Torisu T, Athanasou NA. 2001. The effect of macrophage-colony stimulating factor and other humoral factors interleukin-1, -3, -6, and -11, tumor necrosis factor-alpha, and granulocyte macrophage-colony stimulating factor on human osteoclast formation from circulating cells. Bone 28:261-267.
9. Gorodeski GI. 2000. cGMP-dependent ADP depolymerization of actin mediates estrogen increase in cervical epithelial permeability. Am J Physiol Cell Physiol 279:C2028-C2036.
10. Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF. 1994. c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodelling. Science 266:443-448.
11. Iotsova V, Caamano J, Loy J, Yang Y, Lewin A, Bravo R. 1997. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 3:1285-1289.
12. Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC. 2001. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity. Cell 104:719-730.
13. Lowe C, Yoneda T, Boyce BF, Chen H, Mundy GR, Soriano P. 1993. Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. Proc Natl Acad Sci USA 90:4485-4489.
14. Matsuo K, Owens JM, Tonko M, Elliott C, Chambers TJ, Wagner EF. 2000. Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation. Nat Genet 24:184-187.
15. McHugh KP, Hodivala-Dilke K, Zheng MH, Namba N, Lam J, Novack D, Feng X, Ross FP, Hynes RO, Teitelbaum SL. 2000. Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest 105:433-440.
16. Pujol P, Rey JM, Nirde P, Roger P, Gastaldi M, Laffargue F, Rochefort H, Maudelonde T. 1998. Differential expression of estrogen receptor-α and β messenger RNAs as a potential marker of ovarian carcinogenesis. Cancer Res 58:5367-5373.
17. Rey JM, Pujol P, Callier P, Cavailles V, Freiss G, Maudelonde T, Brouillet JP. 2000. Semiquantitative reverse transcription-polymerase chain reaction to evaluate the expression patterns of genes involved in the oestrogen pathway. J Mol Endocrinol 24:433-440.
18. Riggs BL. 2000. The mechanisms of estrogen regulation of bone resorption. J Clin Invest 106:1203-1204.
19. Shevde NK, Bendixen AC, Dienger KM, Pike JW. 2000. Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression. Proc Natl Acad Sci USA 97:7829-7834.
20. Soriano P, Montgomery C, Geske R, Bradley A. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693-702.
21. Spelsberg TC, Subramaniam M, Riggs BL, Khosla S. 1999. The actions and interactions of sex steroids and growth factors/cytokines on the skeleton. Mol Endocrinol 13:819-828.
22. Srivastava S, Weitzmann MN, Cenci S, Ross FP, Adler S, Pacifici R. 1999. Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. J Clin Invest 104:503-513.
23. Srivastava S, Toraldo G, Weitzmann MN, Cenci S, Ross FP, Pacifici R. 2001. Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand RANKL-induced JNK activation. J Biol Chem 276:8836-8840.
24. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. 1999. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20:345-357.
25. Teitelbaum SL. 2000. Osteoclasts, integrins, and osteoporosis. J Bone Miner Metab 18:344-349.
26. Tsurukai T, Udagawa N, Matsuzaki K, Takahashi N, Suda T. 2000. Roles of macrophage-colony stimulating factor and osteoclast differentiation factor in osteoclastogenesis. J Bone Miner Metab 18:177-184.
27. Udagawa N, Takahashi N, Jimi E, Matsuzaki K, Tsurukai T, Itoh K, Nakagawa N, Yasuda H, Goto M, Tsuda E, Higashio K, Gillespie MT, Martin TJ, Suda T. 1999. Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: Receptor activator of NF-kappa B ligand. Bone 25:517-523.
28. Zhao H, Ross FP, Teitelbaum SL, Novack DV. 2002. Prevention of ovariectomy-induced bone loss in b3 integrin knockout mice. J Bone Miner Res 17(Suppl 1):n1033.