Corrective effects of interleukin-12 on age-related deficiencies in IFN- γ production and IL-12Rβ2 expression in virus-specific CD8+ T cells

Journal of Interferon and Cytokine Research

Volumn 20, Issue 2, 2000, Pages 235-245

  Zhang, Yongxin ^a   Acuna, Catherine L ^a   Switzer, Kirsten C ^a   Song, Ling ^a   Sayers, Robinlyn ^a   Mbawuike, Innocent N ^a  

^a Respiratory Pathogens Research Unit   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; INFECTION RISK; INFLUENZA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIRUS CELL INTERACTION;

AGING; ANIMALS; BASE SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DNA PRIMERS; GENE EXPRESSION; INFLUENZA A VIRUS; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; RNA, MESSENGER; TH1 CELLS; TH2 CELLS;

ANIMALIA; INFLUENZA VIRUS;

EID: 0033993626     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999000312658     Document Type: Article

References (46)

1. 1. CDC. (1995). Prevention and control of influenza recommendations of the Advisory Committee on Immunization Practices (ACIP). Centers for Disease Control and Prevention. MMWR 44, 1-22
2. 2. Bender, B.S., Croghan, T., Zhang, L., and Small, P.A., Jr. (1992). Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J. Exp. Med. 175, 1143-1145.
3. 3. Mcmichael, A.J., Gotch, F.M., Noble, G.R., and Beare, P.A. (1983). Cytotoxic T cell immunity to influenza. N. Engl. J. Med. 309, 13-17.
4. 4. Mbawuike, I.N., Lange, A.R., And Couch, R.B. (1993). Diminished influenza A virus-specific MHC class I-restricted cytotoxic T lymphocyte activity among elderly persons. Viral Immunol. 6, 55-64.
5. + CTL activity among elderly persons and the enhancing effect of IL-12. Mech. Ageing Dev. 94, 25-39.
6. 6. Powers, D.C. (1993). Influenza A virus-specific cytotoxic T lymphocyte activity declines with advancing age [see Comments]. J. Am. Geriatr. Soc. 41, 1-5.
7. 7. Powers, D.C., and Belshe, R.B. (1993). Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine. J. Infect. Dis. 167, 584-592.
8. 8. Mbawuike, I.N., Acuna, C., Caballero, D., Phamnguyen, K., Gilbert, B., Petribon, P., and Harmon, M. (1996). Reversal of age-related deficient influenza virus-specific CTL responses and IFN-gamma production by monophosphoryl lipid A. Cell. Immunol. 173, 64-78.
9. 9. Mbawuike, I.N., Wyde, P.R., and Anderson, P.M. (1990). Enhancement of the protective efficacy of inactivated influenza A virus vaccine in aged mice by IL-2 liposomes. Vaccine 8, 347-352.
10. 10. Bender, B.S., Johnson, M.P., and Small, P.A. (1991). Influenza in senescent mice: impaired cytotoxic T-lymphocyte activity is correlated with prolonged infection. Immunology 72, 514-519.
11. + T cells. Immunol. Rev. 123, 209-229.
12. 12. Romagnani, S. (1995). Biology of human Th1 and Th2 cells. J. Clin. Immunol. 15, 121-129.
13. 13. Lucey, D.R., Clerici, M., and Shearer, G.M. (1996). Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin. Microbiol. Rev. 9, 532-562.
14. + T cells secreting Th1 or Th2 cytokines. Immunity 2, 271-279.
15. + T cells of Tc1 and Tc2 phenotype. Blood 90, 2089-2096.
16. 16. Mosmann, T.R., Li, L., And Sad, S. (1997). Functions of CD8 T-cell subsets secreting different cytokine patterns. Semin. Immunol. 9, 87-92.
17. 17. Cerwenka, A., Carter, L.L., Reome, J.B., Swain, S.L., and Dutton, R.W. (1998). In vivo persistence of CD8 polaried T cell subsets producing type 1 or type 2 cytokines. J. Immunol. 161, 97-105.
18. 18. Gately, M.K., Warrier, R.R., Honasoge, S., Carvajal, D.M., Faherty, D.A., Connaughton, S.E., Anderson, T.D., Sarmiento, U., Hubbard, B.R., and Murphy, M. (1994). Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. Int. Immunol. 6, 157-167.
19. 19. Chouaib, S., Chehimi, J., Bani, L., Genetet, N., Tursz, T., Gay, F., Trinchieri, G., and Mami-Chouaib, F. (1994). Interleukin 12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T lymphocytes precursors into allospecific cytotoxic effectors. Proc. Natl. Acad. Sci. USA 91, 12659-12663.
20. + T cells through IL-12 produced by Listeria-induced macrophages [see Comments]. Science 260, 547-549.
21. 21. Gately, M.K., Wolitzky, A.G., Quinn, P.M., and Chizzonite, R. (1992). Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell. Immunol. 143, 127-142.
22. 22. Mcfarland, E.J., Harding, P.A., Mawhinney, S., Schooley, R.T., and Kuritzkes, D.R. (1998). In vitro effects of IL-12 on HIV-1-specific CTL lines from HIV-1-infected children. J. Immunol. 161, 513-519.
23. 23. Clerici, M., Lucey, D.R., Berzofsky, J.A., Pinto, L.A., Wynn, T.A., Blatt, S.P., Dolan, M.J., Hendrix, C.W., Wolf, S.F., and Shearer, G.M. (1993). Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 262, 1721-2724.
24. 24. Orange, J.S., Wolf, S.F., and Biron, C.A. (1994). Effects of IL-12 on the response and susceptibility to experimental viral infections. J. Immunol. 152, 1253-1264.
25. 25. Cooper, A.M., Callahan, J.E., Griffin, J.P., Roberts, A.D., and Orme, I.M. (1995). Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis. Infect. Immun. 63, 3259-3265.
26. 26. Bloom, E.T., and Horvath, J.A. (1994). Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity. Implications for the age-related decline in CTL. J. Immunol. 152, 4242-4254.
27. 27. Bloom, E.T., Thompson, W.C., Horvath-Arcidiacono, J.A., and Burd, P.R. (1995). Differential effects of interleukin-12 treatment on gene expression by allostimulated T cells from young and aged mice. Mech. Ageing Dev. 85, 109-124.
28. 28. Chizzonite, R., Truitt, T., Desai, B.B., Nunes, P., Podlaski, F.J., Stern, A.S., and Gately, M.K. (1992). IL-12 receptor. I. Characterization of the receptor on phytohemagglutin in-activated human lymphoblasts. J. Immunol. 148, 3117-3124.
29. 29. Rogge, L., Barberis-Maino, L., Biffi, M., Passini, N., Presky, D.H., Gubler, U., and Sinigaglia, F. (1997). Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185, 825-831.
30. 30. Szabo, S.J., Dighe, A.S., Gubler, U., and Murphy, K.M. (1997). Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185, 817-824.
31. 31. Mbawuike, I.N., Six, H.R., Cate, T.R., and Couch, R.B. (1990). Vaccination with inactivated influenza A virus during pregnancy protects neonatal mice against lethal challenge by influenza A viruses representing three subtypes. J. Virol. 64, 1370-1374.
32. 32. Mcmichael, A. (1994). Cytotoxic T lymphocytes specific for influenza virus. Curr. Top. Microbiol. Immunol. 189, 75-91.
33. 33. Harriman, G.R., Bogue, M., Rogers, P., Finegold, M., Pacheco, S., Bradley, A., Zhang, Y., and Mbawuike, I.N. (1999). Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes. J. Immunol. 162, 2521-2529.
34. + T cells. Int. Immunol. 6, 11-19.
35. + memory T cells. J. Exp. Med. 186, 859-865.
36. 36. Gately, M.K., Carvajal, D.M., Connaughton, S.E., Gillessen, S., Warrier, R.R., Kolinsky, K.D., Wilkinson, V.L., Dwyer, C.M., Higgins, G.F., Jr., Podlaski, F.J., Faherty, D.A., Familletti, P.C., Stern, A.S., and Presky, D.H. (1996). Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo. Ann. NY Acad. Sci. 795, 1-12.
37. 37. Gillessen, S., Carvajal, D., Ling, P., Podlaski, F.J., Stremlo, D.L., Familletti, P.C., Gubler, U., Presky, D.H., Stern, A.S., and Gately, M.K. (1995). Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25, 200-206.
38. 38. Castle, S., Uyemura, K., Wong, W., Modlin, R., And Effros, R. (1997). Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents. Mech. Ageing Dev. 94, 7-16.
39. 39. Segal, R., Dayan, M., Globerson, A., Habut, B., Shearer, G.M., and Mozes, E. (1997). Effect of aging on cytokine production in normal and experimental systemic lupus erythematosus afflicted mice. Mech. Ageing Dev. 96, 47-58.
40. 40. Shearer, G.M. (1997). Th1/Th2 changes in aging. Mech. Ageing Dev. 94, 1-5.
41. + T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression. J. Immunol. 151, 575-587.
42. + T cells from young and old mice. J. Immunol. 150, 3602-3614.
43. 43. Engwerda, C.R., Fox, B.S., and Handwerger, B.S. (1996). Cytokine production by T lymphocytes from young and aged mice. J. Immunol. 156, 3621-3630.
44. 44. Kato, K., Shimozato, O., Hoshi, K., Wakimoto, H., Hamada, H., Yagita, H., and Okumura, K. (1996). Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection. Proc. Natl. Acad. Sci. USA 93, 9085-9089.
45. 45. Mattner, F., Magram, J., Ferrante, J., Launois, P., Di Padova, K., Behin, R., Gately, M.K., Louis, J.A., And Alber, G. (1996). Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 26, 1553-1559.
46. 46. Castle, S.C., Uyemura, K., Crawford, W., Wong, W., Klaustermeyer, W.B., and Makinodan, T. (1999). Age-related impaired proliferation of peripheral blood mononuclear cells is associated with an increase in both IL-10 and IL-12 [In Process Citation]. Exp. Gerontol. 34, 243-252.