(23S)- and (23R)-25-dehydro-1α-hydroxyvitamin D3-26,23-lactone function as antagonists of vitamin D receptor-mediated genomic actions of 1α,25-dihydroxyvitamin D3

Steroids

Volumn 66, Issue 3-5, 2001, Pages 227-237

  Ishizuka, Seiichi ^a   Miura, Daishiro ^a   Ozono, Keiichi ^b   Saito, Mariko ^b   Eguchi, Hiroshi ^a   Chokki, Manabu ^a   Norman, Anthony W ^c  

^a TEIJIN LTD   (Japan)

^b RESEARCH INSTITUTE FOR MATERNAL AND CHILD HEALTH   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

1 ,25 (OH)2D3; 1 ,25 (OH)2D3 26,23 lactone analogues; 25 OH D3 24 hydroxylase; Antagonist; Cell differentiation; HL 60 cells

Indexed keywords

1ALPHA HYDROXYVITAMIN D3 26,23 LACTONE; 24 DEHYDRO 1ALPHA HYDROXYVITAMIN D3 26,23 LACTONE; 25 DEHYDRO 1ALPHA HYDROXYVITAMIN D3 26,23 LACTONE; 25 HYDROXYCOLECALCIFEROL 24 HYDROXYLASE; ALITRETINOIN; CALCITRIOL; CALCITRIOL 26,23 LACTONE; CELL NUCLEUS RECEPTOR; COLECALCIFEROL DERIVATIVE; DIMER; HETERODIMER; OXYGENASE; PHORBOL 13 ACETATE 12 MYRISTATE; RETINOIC ACID; RETINOID X RECEPTOR; TEI 9616; TEI 9647; TEI 9648; TEI D1807; TEI D1808; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; VITAMIN D RECEPTOR ANTAGONIST;

CELL DIFFERENTIATION; CELL STRAIN HL 60; CONFERENCE PAPER; CONTROLLED STUDY; DIMERIZATION; DNA RESPONSIVE ELEMENT; DRUG INHIBITION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GENE EXPRESSION; GENOME; HUMAN; HUMAN CELL; MAMMAL CELL; RECEPTOR AFFINITY; STEREOISOMERISM; VITAMIN D RESPONSIVE ELEMENT;

CALCITRIOL; CELL DIFFERENTIATION; CYTOCHROME P-450 ENZYME SYSTEM; DIMERIZATION; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HISTONE ACETYLTRANSFERASES; HL-60 CELLS; HUMANS; PROTEIN BINDING; RECEPTORS, CALCITRIOL; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; RNA, MESSENGER; STEREOISOMERISM; STEROID HYDROXYLASES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 0035342731     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(00)00146-X     Document Type: Conference Paper

References (37)

1. 3-26,23-lactone in rat serum
2. 3-26,23-lactone in the rat
3. 3
4. 3-26,23-lactone. Stereo-retained and stereo-selective lactonization
5. 3-26,23-lactone
6. 3-26,23-lactone
7. 3-26,23-lactone on alkaline phosphatase and collagen synthesis in osteoblastic cells
8. 3-mediated fusion of mouse bone marrow mononuclear cells
9. 3-26,23-lactone and its intermediate metabolites in vivo and in vitro
10. 3-26,23-lactone stimulates murine bone formation in vivo
11. 3-26,23-lactone stimulates matrix synthesis in chondrocytes from rabbit costal growth cartilage
12. 3
13. Structure-function relationships in the vitamin D endocrine system
14. 3 analogue toward vitamin D receptor function
15. 3-lactone analogues
16. 3 to chick intestinal receptor
17. Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide
18. 3-24-hydroxylase gene promoter and identification of two vitamin D-responsive elements
19. 3-26,23-lactone analogs antagonize differentiation of human leukemia cells (HL-60 cells) but not of human acute promyelocytic leukemia cells (NB4 cells)
20. 3 derivatives in inducing differentiation of HL-60 human promyelocytic leukemia cells
21. Analysis of vitamin D analog-induced heterodimerization of vitamin D receptor with retinoid X receptor using the yeast two-hybrid system
22. Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog
23. 3 analog KH1060
24. 3 and its A-ring-modified analogs
25. 3
26. Molecular basis of agonism and antagonism in the oestrogen receptor
27. Basic guide to the mechanisms of antiestrogen action
28. The vitamin D receptor and its gene
29. The nuclear vitamin D receptor; Biological and molecular regulatory properties revealed
30. 3
31. 3; A case study of transcaltachia (rapid hormonal stimulation of intestinal calcium transport)
32. 3 indicates that 6-s-cis conformation is preferred for rapid nongenomic biological responses and that neither 6-s-cis nor 6-s-trans locked analogs are preferred for genomic biological responses
33. 3 of whole cell chloride currents in osteoblastic ROS 17/2.8 cells; a structure-function study
34. 3 in promyelocytic NB4 leukemia cells; a structure-function study
35. 3 is independent of nuclear receptor binding
36. 3 primes acute promyelocytic cells for TPA-induced monocytic differentiation through both PKC and tyrosine phosphorylation cascades
37. 3 stimulates expression and translocation of protein kinase Calpha and Cdelta via a nongenomic mechanism and rapidly induced phosphorylation of a 33-kDa protein in acute promyelocytic NB4 cells