The gastrointestinal tract in critical illness: Nutritional implications

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 6, Issue 5, 2003, Pages 587-591

  Schmidt, Hank ^a   Martindale, Robert ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Critical care; Critical illness; Gastrointestinal tract; Mucosal immunity; Nutrition

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA2 INTEGRIN; CYCLOOXYGENASE 2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTOXIN; GLUCOSE; GLUTAMINE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 72; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; INTERLEUKIN 8; LACTOFERRIN; NITRIC OXIDE; PADGEM PROTEIN; PLACEBO; PROBIOTIC AGENT; PYRUVIC ACID; RINGER SOLUTION; TRACE ELEMENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; CLINICAL TRIAL; COLOSTRUM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; CYTOKINE RELEASE; ENTERIC FEEDING; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; HUMAN; HYPERGLYCEMIA; IMMUNE SYSTEM; INTESTINE MUCOSA PERMEABILITY; LACTIC ACID BACTERIUM; LACTOBACILLUS PLANTARUM; LENGTH OF STAY; META ANALYSIS; MULTIPLE ORGAN FAILURE; NONHUMAN; NUTRITION; OAT; POSTOPERATIVE INFECTION; RANDOMIZED CONTROLLED TRIAL; RAT; REVIEW; SEPTIC SHOCK; SYSTEMATIC REVIEW; TUBE FEEDING; CROSS INFECTION; DIGESTIVE SYSTEM; IMMUNOLOGY; MICROBIOLOGY; MUCOSAL IMMUNITY; NUTRITIONAL SUPPORT; REPERFUSION INJURY;

ANTIOXIDANTS; CRITICAL ILLNESS; CROSS INFECTION; DIGESTIVE SYSTEM; HUMANS; IMMUNITY, MUCOSAL; MULTIPLE ORGAN FAILURE; NUTRITIONAL SUPPORT; PROBIOTICS; REPERFUSION INJURY;

EID: 1542466527     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-200309000-00014     Document Type: Review

References (45)

1. Freestone PP, Haigh RD, Williams PH, et al. Stimulation of bacterial growth by heat-stable norepinephrine-induced autoinducers. FEMS Microbiol Lett 1991; 172:53-60.
2. Alverdy JC, Laughlin RS, Wu L. Influence of the critically ill state on host-pathogen interactions within the intestine: Gut derived sepsis redefined. Crit Care Med 2003; 31:598-607. This review carefully examines the intricacies of mechanisms in gut derived sepsis. The authors delve deep into the myriad of host-pathogen interactions at the molecular level.
3. Faguy D. Bacterial genomics: The controlled chaos of shifty pathogens. Curr Biol 2000; 10:R498-R501.
4. Ishibashi N, Yamazaki S. Probiotics and safety. Am J Clin Nutr 2001; 73 (Suppl):465S-470S.
5. Bengmark S. Use of pro-, pre-, and synbiotics in the ICU: future options. In: Shikora SA, Martindale RG, Schwaitzberg SD, editors. Nutritional considerations in the intensive care unit: science, rationale, and practice. Denver: ASPEN; 2002. pp. 381-399.
6. Heyman M. Effect of lactic acid bacteria on diarrheal diseases. J Am Coll Nutr 2001; 19:3137-3146.
7. Rayes N, Hansen S, Seehofer D, et al. Early enteral supply of fiber and Lactobacilli versus conventional nutrition: A controlled trial in patients with major abdominal surgery. Nutrition 2002; 18:609-615. A prospective, randomized trial indicated reduced postoperative infection rates in surgical patients receiving enteral fiber solution with Lactobacillus. Comparison between administration of live and heat killed organisms was also studied.
8. Olah A, Belagyi T, Issekutz A, et al. Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis. Br J Surg 2002; 89:1103-1107.
9. Rayes N, Seehofer D, Hansen S, et al. Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: A controlled trial in liver transplant recipients. Transplantation 2002; 74:123-128.
10. Dohler JR, Neberman L. Bovine colostrums in oral treatment of enterogenic endotoxaemia in rats. Crit Care 2002; 6:536-539.
11. Nathens AB, Neff MJ, Jurkovich GJ, et al. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg 2002; 236:814-822.
12. Fink MP. Intestinal epithelial hyperpermeability: update on the pathogenesis of gut mucosal barrier dysfunction in critical illness. Curr Opin Crit Care 2003; 9:143-151.
13. Ceppa EP, Fuh KC, Bulkley GB. Mesenteric hemodynamic response to circulatory shock. Curr Opin Crit Care 2003; 9:127-132.
14. Jakob SM. Splanchnic blood flow in low-flow states. Anesth Analg 2003; 96:1129-1138.
15. Stenson WF. Gastrointestinal inflammation. In: Yamada T, Alpers DH, Laine L, et al. editors. Textbook of gastroenterology. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 1999. pp. 134-135.
16. Eskandari MK, Kalff JC, Billiar TR, et al. LPS-induced muscularis macrophage nitric oxide suppresses rat jejunal circular muscle activity. Am J Physiol Gastrointest Liver Physiol 1999; 277(2 Pt 1):G478-G486.
17. Hori M, Kita M, Torihashi S, et al. Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS. Am J Physiol Gastrointest Liver Physiol 2001; 280:G930-G938.
18. Deitch EA, Shorshtein A, Houghton J, et al. Inducible nitric oxide synthase knockout mice are resistant to diet-induced loss of gut barrier function and intestinal injury. J Gastrointest Surg 2002; 6:599-605. This describes an animal model implicating iNOS as a mediator of total parenteral nutrition-induced gut barrier dysfunction.
19. Gonzales RJ, Moore EE, Ciesla DJ, et al. Post-hemorrhagic shock mesenteric lymph activates human pulmonary microvascular endothelium for in vitro neutrophil-mediated injury: The role of Intercellular Adhesion Molecule-1. J Trauma 2003; 54:219-223.
20. Fukatsu K, Kudsk KA, Zarzaur BL, et al. Increased ICAM-1 and beta2 integrin expression in parenterally fed mice after a gut ischemic insult. Shock 2002; 18:119-124.
21. Nemeth ZH, Deitch EA, Szabo C, Hasko G. Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunol Letters 2003; 85:41-46.
22. Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol 2003; 284:G15-G26.
23. Dayal SD, Hasko G, Lu Q, et al. Trauma/hemorrhagic shock mesenteric lymph upregulates adhesion molecule expression and IL-6 production in human umbilical vein endothelial cells. Shock 2002; 17:491-495.
24. Shi HP, Deitch EA, Da Xu Z, et al. Hypertonic saline improves intestinal mucosa barrier function and lung injury after trauma-hemorrhagic shock. Shock 2002; 17:496-501.
25. Sappington PL, Yang R, Delude RL, Fink MP. Delayed treatment with ethyl pyruvate (EP) ameliorates LPS-induced gut barrier dysfunction in mice. Abstract. Crit Care Med 2002; 30 (Suppl):A9.
26. Knudson MM, Lee S, Erickson V, et al. Tissue oxygen monitoring during hemorrhagic shock and resuscitation: A comparison of Lactated Ringer's solution, hypertonic saline dextran, and HBOC-201. J Trauma 2003; 54:242-252.
27. Ziegler TR, Bazargan N, Leader LM, Martindale RG. Glutamine and the gastrointestinal tract. Curr Opin Clin Nutr Metab Care 2000; 3:355-362.
28. DeBandt JP, Cynober LA. Amino acids with anabolic properties. Curr Opin Clin Nutr Metab Care 1998; 1:263-272.
29. Kelly D, Wischmeyer PE. Role of L-glutamine in critical illness: new insights. Curr Opin Clin Nutr Metab Care 2003; 6:217-222.
30. Wischmeyer PE, Kahana MD, Wolfson R, et al. Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia. Shock 2001; 16:398-402.
31. Wischmeyer PE, Riehm J, Singleton KD, et al. Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition 2003; 19:1-6.
32. Wischmeyer PE, Vanden Hoek TL, Li C, et al. Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ishemia-reperfusion injury. JPEN J Parenter Enteral Nutr 2003; 27:116-122.
33. Wong H, Ryan M, Wispe JR. Stress response decreases NF-κB nuclear translocation and increases I-κBα expression in A549 cells. J Clin Invest 1997; 99:2423-2428.
34. Hayashi Y, Sawa Y, Fukuyama N, et al. Preoperative glutamine administration induces heat-shock protein 70 expression and attenuates cardiopulmonary bypass induced inflammatory response by regulating nitric oxide synthase activity. Circulation 2002; 106:2601-2607. This animal study demonstrated control of post-bypass inflammation after preoperative glutamine administration. The authors link heat shock protein induction to control of generation of iNOS.
35. Wischmeyer PE, Singleton KD. Post-treatment with single dose of glutamine attenuates IL-18 expression and reduces polymicrobial sepsis-induced mortality. Abstract. Crit Care Med 2002; 30 (Suppl):A11.
36. Manhart N, Vierlinger K, Spittler A, et al. Oral feeding with glutamine prevents lymphocyte and glutathione depletion of Peyer's patches in endotoxemic mice. Ann Surg 2002; 234:92-97. This animal study revealed that oral glutamine diet preserves antioxidant capacity in the gut during bacteremia.
37. Goeters C, Wenn A, Mertes N, et al. Parenteral l-alanyl-l-glutamine improves 6-month outcome in critically ill patients. Crit Care Med 2002; 30:2032-2037.
38. Ritz M, Fraser R, Tam W, Dent J. Impacts and patterns of disturbed gastrointestinal function in critically ill patients. Am J Gastroenterology 2000; 95:3044-3052.
39. Bauer AJ, Schwarz NT, Moore BA, et al. Ileus in critical illness: mechanisms and management. Curr Opin Crit Care 2002; 8:152-157.
40. Kalff JC, Turler A, Schwarz NT, et al. Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg 2003; 237:301-315. This combination of laboratory and clinical data links postoperative gut motility changes to generation of inflammatory mediators by resident macrophages in the muscularis.
41. Bruins MJ, Luiking YC, Soeters PB. et al. Effect of prolonged hyperdynamic endotoxemia on jejunal motility in fasted and enterally fed pigs. Ann Surg 2003; 237:44-52.
42. Meissner W, Dohrn B, Reinhart K. Enteral naloxone reduces gastric tube reflux and frequency of pneumonia in critical care patients during opioid analgesia. Crit Care Med 2002; 31:776-780.
43. Berne J, Norwood S, McAuley C, et al. Erythromycin reduces delayed gastric emptying in critically ill trauma patients: A randomized, controlled trial. J Trauma 2002; 53:422-425.
44. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345:1359-1367.
45. Rayner CK, Samsom M, Jones KL, Horowitz M. Relationships of upper gastrointestinal motor and sensory function with glycemic control. Diabetes Care 2001; 24:371-381.