Cyclic AMP prevents an increase in GAP-43 but promotes neurite growth in cultured adult rat dorsal root ganglion neurons

Experimental Neurology

Volumn 166, Issue 1, 2000, Pages 153-165

  Andersen, Parker L ^a   Webber, Christine A ^a   Kimura, Karen A ^a   Schreyer, David J ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Axon growth; Cyclic AMP; Dorsal root ganglion; GAP 43; Neurite; Regeneration; Tissue culture

Indexed keywords

CYCLIC AMP; NEUROMODULIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL SURVIVAL; FEMALE; GENE EXPRESSION; NERVE FIBER GROWTH; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINAL GANGLION;

EID: 0033757089     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7485     Document Type: Article

References (98)

1. Absence of persistent spreading, branching, and adhesion in GAP-43-depleted growth cones
2. Constitutive expression of GAP-43 correlates with rapid, but not slow, regrowth of injured dorsal root axons in the adult rat
3. Divergent regulation of GAP-43 expression and CNS neurite outgrowth by cyclic AMP
4. Neurite outgrowth in PC12 cells deficient in GAP-43
5. Recognition of specific targets by cultured dorsal root ganglion neurons
6. Oligodendrocytes arrest neurite growth by contact inhibition
7. Primary structure and transcriptional regulation of GAP-43, a protein associated with nerve growth
8. Extensive elongation of axons from rat brain into peroneal nerve grafts
9. GAP-43: An intrinsic determinant of neuronal development and plasticity
10. Coordinated up-regulation of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor alpha, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line
11. Dependence of GAP-43 (B50, F1) transport on axonal regeneration in rat dorsal root ganglion neurons
12. Electrophysiological study of conditioning lesion effect on rat sciatic nerve regeneration following either prior section or freeze. I. Intensity and time course
13. Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals
14. Growth and differentiation of neural cells in defined medium
15. Gating of BDNF-induced synaptic potentiation by cAMP
16. Nerve growth factor stimulates GAP-43 expression in PC12 cell clones independently of neurite outgrowth
17. The downregulation of growth-associated proteins in motoneurons at the onset of synapse elimination is controlled by muscle activity and IGF1
18. Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading
19. GAP-43 mRNA in rat spinal cord and dorsal root ganglia neurons: Developmental changes and re-expression following peripheral nerve injury
20. GAP-43 expression in primary sensory neurons following central axotomy
21. Intrinsic versus extrinsic factors in determining the regeneration of the central processes of rat dorsal root ganglion neurons: The influence of the peripheral graft
22. Axonal elongation into peripheral nervous system bridges after central nervous system injury
23. Evidence that endogenous NGF is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats
24. Endogenous NGF and nerve impulses regulate the collateral sprouting of sensory axons in the skin of the adult rat
25. Sensory nerves in adult rats regenerate and restore sensory function to the skin independently of endogenous NGF
26. Peripheral nerve regeneration
27. Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: Differential regulation of GAP-43, tubulins, and neurofilament-M
28. CREB: A major mediator of neuronal neurotrophin responses
29. Time course of the conditioning lesion effect on axonal regeneration
30. Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones
31. Changes in the distribution of GAP-43 during the development of neuronal polarity
32. Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro
33. B50/GAP-43 binds to actin filaments without affecting actin polymerization and neurofilament organization
34. Expression of GAP-43, a rapidly transported growth-associated protein, and class II beta tubulin, a slowly transported cytoskeletal protein, are coordinated in regenerating neurons
35. Tailoring cAMP-signalling responses through isoform multiplicity
36. Neurite outgrowth and GAP-43 mRNA expression in cultured adult rat dorsal root ganglion neurons: Effects of NGF or prior axotomy
37. Quantitation of the growth associated protein B50/GAP-43 and neurite outgrowth in PC12 cells
38. Neurotrophin induced cAMP and IP3 responses in PC12 cells. Different pathways
39. Neurotrophin induced second messenger responses in rat brain synaptosomes
40. Effects of dibutyryl cyclic adenosine monophosphate, ACTH(4-10) and gangliosides on nerve fiber regeneration after sciatic nerve tubulization
41. Retinal ganglion cell axon progression from the optic chiasm to initiate optic tract development requires cell autonomous function of GAP-43
42. Involvement of growth associated protein-43 with irreversible neurite outgrowth by dibutyryl cyclic AMP and phorbol ester in NG108-15 cells
43. Magnitude of GAP-43 induction following peripheral axotomy of adult rat dorsal root ganglion is independent of lesion distance
44. Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons
45. Regulation of free calmodulin levels by neuromodulin: Neuron growth and regeneration
46. Asymmetric modulation of cytosolic cAMP activity induces growth cone turning
47. An antineuronal monoclonal antibody that reverses neurite growth inhibition by central nervous system myelin
48. Rho family GTP-binding proteins in growth cone signalling
49. G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor
50. Image analysis of neuritic regeneration by adult rat dorsal root ganglion neurons in culture: Quantification of the neurotoxicity of anticancer agents and of its prevention by nerve growth factor or basic fibroblast growth factor but not brain-derived neurotrophic factor or neurotrophin-3
51. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth
52. Axon outgrowth enhanced by a previous nerve injury
53. Effect of acetoxycycloheximide and dibutyryladenosine cyclic 3':5'-monophosphate on axonal regeneration in the goldfish optic nerve
54. Growth associated protein GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones
55. GAP-43 in growth cones is associated with areas of membrane that are tightly bound to substrate and is a component of a membrane skeleton subcellular fraction
56. Neurite outgrowth stimulated by neural cell adhesion molecules requires growth-associated protein-43 (GAP-43) function and is associated with GAP-43 phosphorylation in growth cones
57. cAMP-dependent growth cone guidance by netrin-1
58. Nerve growth factor and neurotrophin-3 enhance neurite outgrowth and up-regulate the levels of messenger RNA for growth-associated protein GAP-43 and Tα1 α-tubulin in cultured adult rat sensory neurones
59. The effect of the B subunit of cholera toxin on the action of nerve growth factor on PC12 cells
60. Ganglioside GM1 binds to the Trk protein and regulates receptor function
61. Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
62. The neuronal growth-associated protein GAP-43 interacts with rabaptin-5 and participates in endocytosis
63. NGF-induced stabilization of GAP-43 mRNA is mediated by both 3' untranslated region and a segment encoding the carboxy-terminus peptide
64. Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP
65. Posttranscriptional regulation of GAP-43 gene expression in PC12 cells through protein kinase C-dependent stabilization of the mRNA
66. B-50/GAP-43 mRNA expression in cultured primary Schwann cells is regulated by cyclic AMP
67. Axons from CNS neurones regenerate into PNS grafts
68. Peripheral injury enhances central regeneration in primary sensory neurones
69. The induction of a regenerative propensity in sensory neurons following peripheral axonal injury
70. cAMP analogues promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independent of nerve growth factor
71. Expression of growth associated protein-43 kD in Schwann cells is regulated by axon-Schwann cell inter-actions and cAMP
72. Fate of GAP-43 in ascending spinal axons of DRG neurons after peripheral nerve injury: Delayed accumulation and correlation with regenerative potential
73. Injury-induced GAP-43 expression displays axon branch specificity in adult rat dorsal root ganglion neurons
74. Quantitative analysis of GAP-43 expression by neurons in microcultures using cell-ELISA
75. Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro
76. Inhibition of neurite outgrowth following intracellular delivery of anti-GAP-43 antibodies depends upon culture conditions and method of neurite induction
77. Dual pathways regulate neurite outgrowth in enteric ganglia
78. Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems
79. A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes
80. Axonal growth associated proteins
81. Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43
82. A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth
83. cAMP-induced switching in turning direction of nerve growth cones
84. Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides
85. TGFb-s and cAMP regulate GAP-43 expression in Schwann cells and reveal the association of this protein with the trans-Golgi network
86. 0 is a major growth cone protein subject to regulation by GAP-43
87. GAP-43 as a plasticity protein in neuronal form and repair
88. Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43
89. Axonal transport and localization of B-50/GAP-43-like immunoreactivity in regenerating sciatic and facial nerves of the rat
90. Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells
91. 5HT1A receptor agonist differentially increases cyclic AMP concentration in intact and lesioned goldfish retina: In vitro inhibition of outgrowth by forskolin
92. Expression of growth-associated protein B-50 (GAP43) in dorsal root ganglia and sciatic nerve during regenerative sprouting
93. Correlation between GAP43 and nerve growth factor receptors in rat sensory neurons
94. Neurotrophins and nerve injury in the adult
95. cAMP-mediated regulation of neurotrophin-induced collapse of nerve growth cones
96. Phenotypic modification of primary sensory neurons: The role of nerve growth factor in the production of persistent pain
97. Nerve growth factor enhances arborization of adult sensory neurons: A study in single cell culture
98. Membrane-targeting signal in the amino terminus of the neuronal protein GAP-43