Highly Discriminating Protein-Protein Interaction Specificities in the Context of a Conserved Binding Energy Hotspot

Journal of Molecular Biology

Volumn 337, Issue 3, 2004, Pages 743-759

  Li, Wei ^a,c   Keeble, Anthony H ^a,d   Giffard, Catriona ^a,e   James, Richard ^b   Moore, Geoffery R ^a   Kleanthous, Colin ^a,d  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF YORK   (United Kingdom)

^e Masterfoods Australia New Zealand   (Australia)

Author keywords

Alanine scanning; DNase, domains from colicins E2, E7, E8 and E9 are identified, for example, as E2 DNase in the case of the E2 enzyme; Dual recognition; Evolution; Hotspot; Specificity

Indexed keywords

COLICIN; COLICIN E2; COLICIN E7; COLICIN E8; COLICIN E9; COLICIN FACTOR; DEOXYRIBONUCLEASE; ENDONUCLEASE; IMMUNITY PROTEIN; IMMUNITY PROTEIN IM2; IMMUNITY PROTEIN IM7; IMMUNITY PROTEIN IM8; IMMUNITY PROTEIN IM9; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; DNA LIBRARY; ENZYME KINETICS; HYDROPHOBICITY; MOLECULAR RECOGNITION; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

EID: 1542358785     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.02.005     Document Type: Article

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