Naturally Occurring Inhibitors of Protein Serine/Threonine Phosphatases

Handbook of Cell Signaling: Volume 1-3

Volumn 1-3, Issue , 2003, Pages 607-611

  MacKintosh, Carol ^a   Diplexcito, Julie ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 1542341126     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012124546-7/50463-0     Document Type: Chapter

References (26)

1. P.T.W. Cohen (2003) Protein serine/threonine phosphatases and the PPP family. R. Bradshaw, E. Dennis,(Eds) Handbook of Cell Signaling Vol. 1 San Diego, CA: Academic Press chap. 99
2. S. Klumpp, P. Cohen and J.E. Schultz (1990) Okadaic acid, an inhibitor of protein phosphatase 1 in Paramecium, causes sustained Ca2(+)-dependent backward swimming in response to depolarizing stimuli. EMBO J. 9 685-689.
3. C. MacKintosh, G.D. Lyon and R.W. MacKintosh (1994) Protein phosphatase inhibitors activate anti-fungal defence responses of soybean cotyledons and cell cultures. Plant J. 5 137-147.
4. T. Sandal, R. Ahlgren, J. Lillehaug and S.O. Doskeland (2001) Establishment of okadaic acid resistant cell clones using a cDNA expression library. Cell Death Differ 8 754-766.
5. B. Favre, P. Turowski and B.A. Hemmings (1997) Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J. Biol. Chem. 272 13856-13863.
6. D.R. Evans and J.A. Simon (2001) The predicted beta12-beta13 loop is important for inhibition of PP2Acα by the antitumor drug fostriecin. FEBS Lett. 498 110-115.
7. R.S. de Jong, N.H. Mulder, D.R. Uges, D.T. Sleijfer, F.J. Hoppener, H.J. Groen, P.H. Willemse, W.T. van der Graaf and E.G. de Vries (1999) Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. Br. J. Cancer 79 882-887.
8. I. Chorus and J. Bartram (Eds) (1999) Toxic Cyanobacteria in Water: A Guide to Their Public Health Consequences, Monitoring and Management London: E&FN Spon
9. J. Goldberg, H.B. Huang, Y.G. Kwon, P. Greengard, A.C. Nairn and J. Kuriyan (1995) Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature 376 745-753.
10. J.T. Maynes, K.S. Bateman, M.M. Cherney, A.K. Das, H.A. Luu, C.F. Holmes and M.N. James (2001) Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1. J. Biol. Chem. 276 44078-44082.
11. M.P. Egloff, P.T. Cohen, P. Reinemer and D. Barford (1995) Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate. J. Mol. Biol. 254 942-959.
12. R.W. MacKintosh, K.N. Dalby, D.G. Campbell, P.T. Cohen, P. Cohen and C. MacKintosh (1995) The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. FEBS Lett. 371 236-240.
13. H.B. Huang, A. Horiuchi, J. Goldberg, P. Greengard and A.C. Nairn (1997) Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding. Proc. Natl. Acad. Sci. USA 94 3530-3535.
14. J.H. Connor, T. Kleeman, S. Barik, R.E. Honkanen and S. Shenolikar (1999) Importance of the β12–β13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. J. Biol. Chem. 274 22366-22372.
15. K.E. Volter, K.J. Embrey, G.K. Pierens and R.J. Quinn (2001) A study of the binding requirements of calyculin A and dephosphonocalyculin A with PP1: development of the okadaic acid class of compounds with PP1. Eur. J. Pharm. Sci. 12 181-194.
16. J. Sheppeck, W. Liu and A.R. Chamberlin (1997) Synthesis of the serine-threonine -specific phosphatase inhibitor tautomycin. J. Org. Chem. 62 387-398.
17. A.B. Smith, G.K. Friestad, J. Barbosa, E. Bertounesque, J.J.H. Duan, K.G. Hull, M. Iwashima, Y.P. Qiu, P.G. Spoors and B.A. Salvatore (1999) Total synthesis of (+)-calyculin A and (−)-calyculin B: cyanotetraene construction, asymmetric synthesis of the C(26–37) oxazole, fragment assembly, and final elaboration. J. Am. Chem. Soc. 121 10478-10486.
18. J.H. Humphrey, J. Aggen and A.R. Chamberlin (1996) Synthesis of the serine-threonine phosphatase inhibitor microcystin LA. J. Am. Chem. Soc. 118 11759-11770.
19. D.L. Boger, S. Ichikawa and W. Zhong (2001) Total synthesis of fostriecin (CI-920). J. Am. Chem. Soc. 123 4161-4167.
20. A. Takai, K. Tsuboi, M. Koyasu and M. Isobe (2000) Effects of modification of the hydrophobic C-1-C-16 segment of tautomycin on its affinity to type-1 and type-2A protein phosphatases. Biochem. J. 350 81-88.
21. A. McCluskey and J.A. Sakoff (2001) Small molecule inhibitors of serine/threonine protein phosphatases. Mini Rev. Med. Chem. 1 43-55.
22. G. Moorhead, R.W. MacKintosh, N. Morrice, T. Gallagher and C. MacKintosh (1994) Purification of type 1 protein (serine/threonine) phosphatases by microcystin-Sepharose affinity chromatography. FEBS Lett 356 46-50.
23. M. Campos, P. Fadden, G. Alms, Z. Qian and T.A. Haystead (1996) Identification of protein phosphatase-1-binding proteins by microcystin-biotin affinity chromatography. J. Biol. Chem. 271 28478-28484.
24. M.H. Serres, K.E. Fladmark and S.O. Doskeland (2000) An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases. Toxicon 38 347-360.
25. B.H. Liu, F.Y. Yu, X. Huang and F.S. Chu (2000) Monitoring of microcystin-protein phosphatase adduct formation with immunochemical methods. Toxicon 38 619-632.
26. W.W. Carmichael, S.M. Azevedo, J.S. An, R.J. Molica, E.M. Jochimsen, S. Lau, K.L. Rinehart, G.R. Shaw and G.K. Eaglesham (2001) Human fatalities from cyanobacteria: chemical and biological, evidence for cyanotoxins. Environ. Health Perspect. 109 663-668.