Riluzole restores motor activity in rats with post-traumatic peripheral neuropathy

Neuroscience Letters

Volumn 358, Issue 1, 2004, Pages 37-40

  Medico, M ^a   Nicosia, A ^a   Grech, M ^a   Onesta, M ^a   Sessa, G ^a   Rampello, L ^a   Drago, F ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Nerve crushing; Neuropathy; Neuroprotection; Post traumatic; Riluzole; Sciatic nerve

Indexed keywords

DICLOFENAC; NEUROPROTECTIVE AGENT; R 136; RILUZOLE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; MOBILIZATION; MOTOR ACTIVITY; MOTOR COORDINATION; MOTOR PERFORMANCE; NERVE CRUSH; NEUROPROTECTION; NONHUMAN; OPEN FIELD BEHAVIOR; OPEN FIELD TEST; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; RAT STRAIN; SCIATIC NERVE; SCIATIC NEUROPATHY;

ANIMALS; MALE; MOTOR ACTIVITY; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, WISTAR; RILUZOLE; SCIATIC NEUROPATHY;

EID: 1542315484     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2003.12.090     Document Type: Article

References (20)

1. Ankarcrona M., Dypbukt J.M., Bonfoco E. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 15:1995;961-973.
2. Bennett G.J., Xie Y.K. A peripheral mononeuropathy in rat produces disorders of pain sensation like those seen in man. Pain. 33:1998;87-107.
3. Doble A. The pharmacology and mechanism of action of riluzole. Neurology. 47:1996;S233-S241.
4. Grace R.F., Lin Y., Edwards S.R., Power I., Mather L.E. Effects of diclofenac in the rat tail ischaemia-reperfusion injury model of acute hyperalgesia. Pain. 89:2001;117-125.
5. Hammer N.A., Lilleso J., Pedersen J.L., Kehlet H. Effect of riluzole on acute pain and hyperalgesia in humans. Br. J. Anaesth. 82:1999;718-722.
6. Keita H., Boczkowski J., Samb A., Lanone S., Lang-Lazdunski L., Rouelle D., Desmonts J.M., Mantz J. Anesthetic concentrations of riluzole inhibit neuronal nitric oxide synthase activity, but not expression, in the rat hippocampus. Brain Res. 881:2000;237-240.
7. Kretschmer B.D., Kratzer U., Schmidt W.J. Riluzole, a glutamate inhibitor, and motor behavior. Naunyn Schmiedebergs Arch. Pharmacol. 358:1998;181-190.
8. Lang-Lazdunski L., Heurteaux C., Dupont H., Widmann C., Lazdunski M. Prevention of ischemic spinal cord injury: comparative effects of magnesium sulfate and riluzole. J. Vasc. Surg. 32:2000;179-189.
9. Lin Y., Mather L.E., Power I., Cousins M.J. The effect of diclofenac on the expression of spinal cord c-fos-like immunoreactivity after ischemia-reperfusion-induced acute hyperalgesia in the rat tail. Anesth. Analg. 90:2000;1141-1145.
10. Mantz J., Cheramy A., Thierry A.M., Glowinski J., Desmonts J.M. Anesthetic properties of riluzole (54274 RP), a new inhibitor of glutamate neurotransmission. Anesthesiology. 76:1992;844-848.
11. Martin D., Thompson M.A., Nadler J.V. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur. J. Pharmacol. 250:1993;473-476.
12. Miller R.G., Mitchell J.D., Moore D.H. Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron desease (MND). Cochrane Database Syst. Rev. 2:2000;CD001447.
13. Mu X., Azbill R.D., Springer J.E. Riluzole improves measures of oxidative stress following traumatic spinal cord injury. Brain Res. 870:2000;66-72.
14. Noh K.M., Hwang J.Y., Shin H.C., Koh J.Y. A novel neuroprotective mechanism of riluzole: direct inhibition of protein kinase C. Neurobiol. Dis. 7:2000;375-383.
15. Sairam K., Saravanan K.S., Banerjee R., Mohanakumar K.P. Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats. Brain Res. 966:2003;245-252.
16. Siniscalchi A., Zona C., Sancesario G., D'Angelo E., Zeng Y.C., Mercuri N.B., Bernardi G. Neuroprotective effects of riluzole: an electrophysiological and histological analysis in an in vitro model of ischemia. Synapse. 32:1999;147-152.
17. Storch A., Burkhardt K., Ludolph A.C., Schwarz J. Protective effects of riluzole on dopamine neurons: involvement of oxidative stress and cellular energy metabolism. J. Neurochem. 75:2000;2259-2269.
18. Wagner M.L., Landis B.E. Riluzole: a new agent for amyotrophic lateral sclerosis. Ann. Pharmacother. 31:1997;738-744.
19. Watzman N.H., Barry H., Buckley J.P. Semiautomatic system for timing rotorod performance. J. Pharm. Sci. 53:1964;1429-1430.
20. Weijen J.A.W.M., Slangen J.L. Effects of ACTH analogues on extinction of conditioned behavior. De Wied D., Weijnen J.A.W.M. Pituitary, Adrenal and the Brain. 1982;221-235 Elsevier, Amsterdam.