Effects of diclofenac in the rat tail ischaemia-reperfusion injury model of acute hyperalgesia

Pain

Volumn 89, Issue 2-3, 2001, Pages 117-125

  Grace, Robert F ^a   Lin, Yiguang ^a   Edwards, Stephen R ^a   Power, Ian ^a   Mather, Laurence E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Diclofenac; Hyperalgesia; Ischemia; Non steroidal anti inflammatory drug; Prostaglandin; Rat; Reperfusion injury

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; DICLOFENAC; ICOSANOID; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; THROMBOXANE B2;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; HYPERALGESIA; ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SPINAL CORD; TAIL; THERMAL INJURY; TREATMENT OUTCOME;

6-KETOPROSTAGLANDIN F1 ALPHA; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; DICLOFENAC; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSANOIDS; HYPERALGESIA; INJECTIONS, SUBCUTANEOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; REPERFUSION INJURY; TAIL; THROMBOXANE B2;

EID: 0035122319     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(00)00372-9     Document Type: Article

References (49)

1. Prostaglandin profiles in nervous tissue and blood vessels of the brain of various animals
2. Localization of cyclooxygenase-2 and prostaglandin E2 receptor EP3 in the rat lumbar spinal cord
3. Response latencies in the tail-flick test depend on tail skin temperature
4. Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat
5. A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors
6. Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines
7. Diazepam attenuates hyperexcitability and mechanical hypersensitivity of dorsal horn convergent neurones during reperfusion of the rat's tail following ischaemia
8. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs
9. Release of prostaglandins E and F in an algogenic reaction and its inhibition
10. Concurrent determination of glutamate and kynurenate in the rat central nervous system following treatment with diclofenac or tail ischaemia
11. Estimation of the in vivo effect of cyclooxygenase inhibitors on prostaglandin E2 levels in mouse brain
12. The hyperalgesic effects of prostacyclin and prostaglandin E2
13. Potential anticonvulsive properties of endogenous prostaglandins formed in mouse brain
14. Modality-specific hypersensitivity of dorsal horn convergent neurones during reperfusion of their receptive fields on the rat's tail
15. Prostanoid synthesis in the spinal cord enhances excitability of dorsal horn convergent neurones during reperfusion of ischaemic receptive fields on the rat's tail
16. Hyperalgesia following ischaemia of the rat's tail
17. Injectable aspirin and mepyramine abolish post-ischaemic hyperalgesia in rats
18. Behavioral and thalamic nociceptive responses in rats following noxious ischaemia of the tail
19. Effects of systemic non-steroidal anti-inflammatory drugs on nociception during tail ischaemia and on reperfusion hyperalgesia in rats
20. Intracerebroventricular micro-injections of nonsteroidal anti-inflammatory drugs abolish reperfusion hyperalgesia in the rat's tail
21. Diclofenac plasma and tissue distribution after subcutaneous injection in the rat
22. Extraction and chromatographic procedures for purification of prostaglandins, thromboxanes, prostacyclin and their metabolites
23. The potential role of spinal cord cyclooxygenase-2 in the development of Freund's complete adjuvant-induced changes in hyperalgesia and allodynia
24. The tail-flick and formalin tests in rodents: Changes in skin temperature as a confounding factor
25. Renal dysfunction associated with the perioperative use of diclofenac
26. Development of an in-vitro test system for the evaluation of cyclooxygenase-2 inhibitors
27. Effect of diclofenac on expression of spinal cord c-fos-like immunoreactivity following ischemia-reperfusion induced hyperalgesia in the rat tail
28. Biochemical evidence for the involvement of nitric oxide in hyperalgesia induced by ischaemia and reperfusion
29. The apparent anti-nociceptive effect of desipramine and zimeldine in the tail flick test in rats is mainly caused by changes in tail skin temperature
30. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat
31. Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: A microdialysis study in unanesthetized rats
32. Dissociation between the anti-nociceptive and antiinflammatory effects of the nonsteroidal anti-inflammatory drugs
33. Spinal mediators of hyperalgesia
34. Habituation to sham testing procedures modifies tail-flick latencies: Effects on nociception rather than vasomotor tone
35. Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation
36. CNS stimulation and PGE2 release. III. Pentamethylenetetrazole-induced seizures
37. Hyperalgesic action in mice of intracerebroventricularly administered arachidonic acid, PG E2, PG F2 alpha and PG D2: Effects of analgesic drugs on hyperalgesia
38. Peripheral noxious stimulation releases spinal PGE2 during the first phase in the formalin assay of the rat
39. Role of N-methyl-D-aspartate and opiate receptors in nociception during and after ischaemia in rats
40. Biochemical mechanisms of ischaemic pain
41. The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam
42. On the sensitivity of the tourniquet pain test
43. Time course of release in vivo of PGE2, PGF2 alpha, 6-keto-PGF 1 alpha, and TxB2 into the brain extracellular space after 15 mm of complete global ischemia in the presence and absence of cyclooxygenase inhibition
44. The formalin test: A dose-response analysis at three developmental stages
45. An improved method for tail-flick testing with adjustment for tail-skin temperature
46. Cyclooxygenases 1 and 2
47. Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil
48. Prostaglandin (PG) modulation of bradykinin-induced hyperalgesia and oedema in the guinea-pig paw - Effects of PGD2, PGE2 and PGI2
49. Prostanoids synthesized by cyclo-oxygenase isoforms in the rat spinal cord and their contribution to the development of neuronal hyperexcitability