Toll-like receptor 4 polymorphism and severity of atopy in asthmatics

Genes and Immunity

Volumn 5, Issue 1, 2004, Pages 41-45

  Yang, I A ^a,c   Barton, S J ^a   Rorke, S ^a   Cakebread, J A ^a   Keith, T P ^b   Clough, J B ^a   Holgate, S T ^a   Holloway, J W ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b GENOME THERAPEUTICS CORPORATION   (United States)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Asthma; Atopy; Polymorphism (genetics); Toll like receptor 4

Indexed keywords

ANTIASTHMATIC AGENT; ASPARTIC ACID; ENDOTOXIN; GLYCINE; IMMUNOGLOBULIN E; METHACHOLINE; TOLL LIKE RECEPTOR 4;

ARTICLE; ASTHMA; ATOPY; CASE CONTROL STUDY; CAUCASIAN; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG USE; FAMILY; FAMILY HISTORY; FORCED EXPIRATORY VOLUME; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; PARENT; PHYSICIAN; POLYMERASE CHAIN REACTION; PREDICTION; PRICK TEST; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; SIBLING; UNITED KINGDOM;

AMINO ACID SUBSTITUTION; ASTHMA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOTYPE; HUMANS; IMMUNOGLOBULIN E; MALE; MEMBRANE GLYCOPROTEINS; POLYMORPHISM, GENETIC; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 1542293368     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6364037     Document Type: Article

References (22)

1. Holgate ST. The epidemic of allergy and asthma. Nature 1999; 402 (Suppl): B2-B4.
2. Strachan DP. Family size, infection and atopy: the first decade of the 'hygiene hypothesis'. Thorax 2000; 55 (Suppl 1): S2-S10.
3. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299: 1259-1260.
4. Liu AH. Endotoxin exposure in allergy and asthma: reconciling a paradox. J Allergy Clin Immunol 2002; 109: 379-392.
5. von Mutius E. Environmental factors influencing the development and progression of pediatric asthma. J Allergy Clin Immunol 2002; 109: S525-S532.
6. Liu AH, Murphy JR. Hygiene hypothesis: fact or fiction? J Allergy Clin Immunol 2003; 111: 471-478.
7. Gereda JE, Leung DY, Thatayatikom A et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000; 355: 1680-1683.
8. Gehring U, Bischof W, Fahlbusch B, Wichmann HE, Heinrich J. House dust endotoxin and allergic sensitization in children. Am J Respir Crit Care Med 2002; 166: 939-944.
9. Braun-Fahrlander C, Riedler J, Herz U et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347: 869-877.
10. Beutler B. Innate immune responses to microbial poisons: discovery and function of the Toll-Like receptors. Annu Rev Pharmacol Toxicol 2003; 43: 609-628.
11. Arbour NC, Lorenz E, Schutte BC et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000; 25: 187-191.
12. Raby BA, Klimecki WT, Laprise C et al. Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Respir Crit Care Med 2002; 166: 1449-1456.
13. Kiechl S, Lorenz E, Reindl M et al. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002; 347: 185-192.
14. Agnese DM, Calvano JE, Hahm SJ et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 2002; 186: 1522-1525.
15. Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with Gram-negative septic shock. Arch Intern Med 2002; 162: 1028-1032.
16. Sayers I, Barton S, Rorke S et al. Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma. Thorax 2003; 58: 417-424.
17. Werner M, Topp R, Wimmer K et al. TLR4 gene variants modify endotoxin effects on asthma. J Allergy Clin Immunol 2003; 112: 323-330.
18. Pearce N, Pekkanen J, Beasley R. How much asthma is really attributable to atopy? Thorax 1999; 54: 268-272.
19. Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. Airway remodeling in asthma: new insights. J Allergy Clin Immunol 2003; 111: 215-225.
20. Van Eerdewegh P, Little RD, Dupuis J et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002; 418: 426-430.
21. Holloway JW, Rorke S, Beghé B, Holgate ST. Genetic influences on asthma severity In: Szefler SJ, Leung DYM (eds). Severe Asthma: Pathogenesis and Clinical Management. Marcel Dekker: New York, 2001 pp 19-38.
22. Ye S, Dhillon S, Ke X, Collins AR, Day IN. An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res 2001; 29: E88-E98.