Intestinal adaptation after massive intestinal resection

Postgraduate Medical Journal

Volumn 81, Issue 953, 2005, Pages 178-184

  Weale, A R ^a,b   Edwards, A G ^a,b   Bailey, M ^b   Lear, P A ^a  

^a SOUTHMEAD HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARBOHYDRATE; EPIDERMAL GROWTH FACTOR; GLUCAGON LIKE PEPTIDE; GLUTAMINE; GROWTH HORMONE; INTERLEUKIN 11; KERATINOCYTE GROWTH FACTOR; LEPTIN; LIPID; NEUROTENSIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SOMATOMEDIN;

ABSORPTION; APOPTOSIS; CELL PROLIFERATION; CLINICAL PRACTICE; COLON DILATATION; CRYPT CELL; HEIGHT; HUMAN; INTESTINE ADAPTATION; INTESTINE EPITHELIUM; INTESTINE GRAFT; INTESTINE RESECTION; INTESTINE VILLUS; PARENTERAL NUTRITION; PROTEIN CONTENT; QUALITY OF LIFE; REVIEW; SHORT BOWEL SYNDROME; SURVIVAL; UPREGULATION;

ADAPTATION, PHYSIOLOGICAL; GROWTH SUBSTANCES; HUMANS; INTESTINE, SMALL; PARENTERAL NUTRITION; SHORT BOWEL SYNDROME;

EID: 15244353607     PISSN: 00325473     EISSN: None     Source Type: Journal    
DOI: 10.1136/pgmj.2004.023846     Document Type: Review

References (137)

1. Fleming CR, Remington M. Intestinal failure. In: Hill GL, ed. Nutrition in the surgical patient. Edinburgh: Churchill Livingstone, 1981:219-35.
2. Bakker H, Bozzetti F, Staun M, et al. Home parenteral nutrition in adults: a europeon multicentre survey in 1997. ESPEN-Home Artificial Nutrition Working Group. Clin Nutr 1999;18:135-40.
3. Richards DM, Irving MH. Assessing the quality of life of patients with intestinal failure on home parenteral nutrition. Gut 1997;40:218-22.
4. Richards DM, Deeks JJ, Sheldon TA, Shaffer JL. Home parenteral nutrition: a systematic review. Health Technol Assess 1997;1:1-59.
5. Buchman AL, Scolapio J, Fryer J. AGA technical review on short bowel syndrome and intestinal transplantation. Gastroenterology 2003;124:1111-34.
6. International Intestinal Transplant Registry 2003. http://www. intestinaltransplantregistry.org.
7. Roberts JP, Brown RS Jr, Edwards EB, et al. Liver and intestine transplantation. Am J Transplant 2003;3(suppl 4):78-90.
8. Messing B, Crenn P, Beau P, et al. Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome. Gastroenterology 1999;117:1043-50.
9. Nygaard K. Resection of the small intestine in rats. 3. Morphological changes in the intestinal tract. Acta Chir Scand 1967;133:233-48.
10. Williamson RC. Intestinal adaptation (first of two parts). Structural, functional and cytokinetic changes. N Engl J Med 1978;298:1393-402.
11. Williamson RC. Intestinal adaptation (second of two parts). Mechanisms of control. N Engl J Med 1978;298:1444-50.
12. Tavakkolizadeh A, Whang EE. Understanding and augmenting human intestinal adaptation: a call for more clinical research. JPEN J Parenter Enteral Nutr 2002;26:251-5.
13. Alpers DH. How adaptable is the intestine in patients with short-bowel syndrome? Am J Clin Nutr 2002;75:787-8.
14. Hanson WR, Osborne JW, Sharp JG. Compensation by the residual intestine after intestinal resection in the rat. I. Influence of amount of tissue removed. Gastroenterology 1977;72:692-700.
15. Hines OJ, Bilchik AJ, Zinner MJ, et al. Adaptation of the Na+/glucose cotransporter following intestinal resection. J Surg Res 1994;57:22-7.
16. Ziegler TR, Fernandez-Estivariz C, Gu LH, et al. Distribution of the H+/peptide transporter PepT1 in human intestine: up-regulated expression in the colonic mucosa of patients with short-bowel syndrome. Am J Clin Nutr 2002;75:922-30.
17. Gouttebel MC, Saint AB, Colette C, et al. Intestinal adaptation in patients with short bowel syndrome. Measurement by calcium absorption. Dig Dis Sci 1989;34:709-15.
18. Nordgaard I, Hansen BS, Mortensen PB. Colon as a digestive organ in patients with short bowel. Lancet 1994;343:373-6.
19. Nightingale JM, Lennard-Jones JE, Gertner DJ, et al. Colonic preservation reduces need for parenteral therapy, increases incidence of renal stones, but does not change high prevalence of gall stones in patients with a short bowel. Gut 1992;33:1493-7.
20. Carbonnel F, Cosnes J, Chevret S, et al. The role of anatomic factors in nutritional autonomy after extensive small bowel resection. JPEN J Parenter Enteral Nutr 1996;20:275-80.
21. Sondheimer JM, Cadnapaphornchai M, Sontag M, et al. Predicting the duration of dependence on parenteral nutrition after neonatal intestinal resection. J Pediatr 1998;132:80-4.
22. Andorsky DJ, Lund DP, Lillehei CW, et al. Nutritional and other postoperative management of neonates with short bowel syndrome correlates with clinical outcomes. J Pediatr 2001;139:27-33.
23. Gruessner RW, Sharp HL. Living-related intestinal transplantation: first report of a standardized surgical technique. Transplantation 1997;64:1605-7.
24. Cicalese L, Baum C, Brown M, et al. Segmental small bowel transplant from adult living-related donors. Transplant Proc 2001;33:1553.
25. Jao W, Sileri P, Holaysan J, et al. Morphologic adaptation following segmental living related intestinal transplantation. Transplant Proc 2002;34:924.
26. Benedetti E, Baum C, Cicalese L, et al. Progressive functional adaptation of segmental bowel graft from living related donor. Transplantation 2001;71:569-71.
27. Bjerknes M, Cheng H. Modulation of specific intestinal epithelial progenitors by enteric neurons. Proc Natl Acad Sci USA 2001;98:12497-502.
28. Ponder BA, Schmidt GH, Wilkinson MM, et al. Derivation of mouse intestinal crypts from single progenitor cells. Nature 1985;313:689-91.
29. Cheng H, Leblond CP. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types. Am J Anat 1974;141:537-61.
30. Wong WM, Wright NA. Cell proliferation in gastrointestinal mucosa. J Clin Pathol 1999;52:321-33.
31. Kellett M, Potten CS, Rew DA. A comparison of in vivo cell proliferation measurements in the intestine of mouse and man. Epithelial Cell Biol 1992;1:147-55.
32. Potten CS. The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metastasis Rev 1992;11:179-95.
33. Scolapio JS. Tales from the crypt. Gastroenterology 2003;124:561-4.
34. Wu G. Intestinal mucosal amino acid catabolism. J Nutr 1998;128:1249-52.
35. Windmueller HG, Spaeth AE. Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine. J Biol Chem 1978;253:69-76.
36. Welters CF, Dejong CH, Deutz NE, et al. Intestinal function and metabolism in the early adaptive phase after massive small bowel resection in the rat. J Pediatr Surg 2001;36:1746-51.
37. Klimberg VS, Souba WW, Salloum RM, et al. Intestinal glutamine metabolism after massive small bowel resection. Am J Surg 1990;159:27-32.
38. Deutz NE, Dejong CH, Athanasas G, et al. Partial enterectomy in the rat does not diminish muscle glutamine production. Metabolism 1992;41:1343-50.
39. Alavi K, Kato Y, Yu D, et al. Enteral glutamine does not enhance the effects of hepatocyte growth factor in short bowel syndrome. J Pediatr Surg 1998;33:1666-9.
40. Sukhotnik I, Lerner A, Sabo E, et al. Effects of enterai arginine supplementation on the structural intestinal adaptation in a rat model of short bowel syndrome. Dig Dis Sci 2003;48:1346-51.
41. Michail S, Mohammadpour H, Park JH, et al. Effect of glutamine- supplemented elemental diet on mucosal adaptation following bowel resection in rats. J Pediatr Gastroenterol Nutr 1995;21:394-8.
42. Vanderhoof JA, Blackwood DJ, Mohammadpour H, et al. Effects of oral supplementation of glutamine on small intestinal mucosal mass following resection. J Am Coll Nutr 1992;11:223-7.
43. Wiren ME, Permert J, Skullman SP, et al. No differences in mucosal adaptive growth one week after intestinal resection in rats given enteral glutamine supplementation or deprived of glutamine. Eur J Surg 1996;162:489-98.
44. Yagi M, Sakamoto K, Inoue T, et al. Effect of a glutamine-enriched elemental diet on regeneration of the small bowel mucosa following isotransplantation of small intestine. Transplant Proc 1994;26:2297-8.
45. Czernichow B, Nsi-Emvo E, Galluser M, et al. Enteral supplementation with ornithine alpha ketoglutarate improves the early adaptive response to resection. Gut 1997;40:67-72.
46. Thiesen AL, Tappenden KA, McBurney MI, et al. Dietary lipids alter the effect of steroids on the transport of glucose after intestinal resection: Part I. Phenotypic changes and expression of transporters. J Pediatr Surg 2003;38:150-60.
47. Koruda MJ, Rolandelli RH, Settle RG, et al. Harry M. Vars award. The effect of a pectin-supplemented elemental diet on intestinal adaptation to massive small bowel resection. JPEN J Parenter Enteral Nutr 1986;10:343-50.
48. Zhang DL, Jiang ZW, Jiang J, et al. D-lactic acidosis secondary to short bowel syndrome. Postgrad Med J 2003;79:110-12.
49. Hajri T, Abumrad NA. Fatty acid transport across membranes: relevance to nutrition and metabolic pathology. Annu Rev Nutr 2002;22:383-415.
50. Hamilton JA. Fatty acid transport: difficult or easy? J Lipid Res 1998;39:467-81.
51. Nordskog BK, Phan CT, Nutting DF, et al. An examination of the factors affecting intestinal lymphatic transport of dietary lipids. Adv Drug Deliv Rev 2001;50:21-44.
52. Sweetser DA, Hauft SM, Hoppe PC, et al. Transgenic mice containing intestinal fatty acid-binding protein-human growth hormone fusion genes exhibit correct regional and cell-specific expression of the reporter gene in their small intestine. Proc Natl Acad Sci USA 1988;85:9611-15.
53. Stahl A. A current review of fatty acid transport proteins (SLC27). Pflugers Arch 2004;447:722-7.
54. Chen M, Yang Y, Braunstein E, et al. Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes. Am J Physiol Endocrinol Metab 2001;281:E916-23.
55. Rubin DC, Swietlicki EA, Wang JL, et al. Enterocytic gene expression in intestinal adaptation: evidence for a specific cellular response. Am J Physiol 1996;270:G143-52.
56. Sukhotnik I, Gork AS, Chen M, et al. Effect of low fat diet on lipid absorption and fatty-acid transport following bowel resection. Pediatr Surg Int 2001;17:259-64.
57. Thiesen A, Wild GE, Tappenden KA, et al. Intestinal resection- and steroid-associated alterations in gene expression were not accompanied by changes in lipid uptake. Digestion 2002;66:112-20.
58. Hart MH, Grandjean CJ, Park JH, et al. Essential fatty acid deficiency and postresection mucosal adaptation in the rat. Gastroenterology 1988;94:682-7.
59. Sukhotnik I, Shiloni E, Krausz MM, et al. Low-fat diet impairs postresection intestinal adaptation in a rat model of short bowel syndrome. J Pediatr Surg 2003;38:1182-7.
60. Kollman-Bauerly KA, Thomas DL, Adrian TE, et al. The role of eicosanoids in the process of adaptation following massive bowel resection in the rat. JPEN J Parenter Enteral Nutr 2001;25:275-81.
61. Park JH, Grandjean CJ, Hart MH, et al. Effects of dietary linoleic acid on mucosal adaptation after small bowel resection. Digestion 1989;44:57-65.
62. Vanderhoof JA, Park JH, Herrington MK, et al. Effects of dietary menhaden oil on mucosal adaptation after small bowel resection in rats. Gastroenterology 1994;106:94-9.
63. Vanderhoof JA, Grandjean Q, Baylor JM, et al. Morphological and functional effects of 16,16-dimethyi-prostaglandin-E2 on mucosal adaptation after massive distal small bowel resection in the rat. Gut 1988;29:802-8.
64. Dahly EM, Guo Z, Ney DM. Alterations in enterocyte proliferation and apoptosis accompany TPN-induced mucosal hypoplosia and IGF-I-induced hyperplasia in rats. J Nutr 2002;132:2010-14.
65. Chance WT, Foley-Nelson T, Thomas I, et al. Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2. Am J Physiol 1997;273:G559-63.
66. Gouttebel MC, Astre C, Briand D, et al. Influence of N-acetylglutamine or glutamine infusion on plasma amino acid concentrations during the early phase of small-bowel adaptation in the dog. JPEN J Parenter Enteral Nutr 1992;16:117-21.
67. Gu Y, Wu ZH, Xie JX, et al. Effects of growth hormone (rhGH) and glutamine supplemented parenteral nutrition on intestinal adaptation in short bowel rats. Clin Nutr 2001;20:159-66.
68. Tamada H, Nezu R, Matsuo Y, et al. Alanyl glutamine-enriched total parenteral nutrition restores intestinal adaptation after either proximal or distal massive resection in rats. JPEN J Parenter Enteral Nutr 1993;17:236-42.
69. Zhou X, Li YX, Li N, et al. Effect of bowel rehabilitative therapy on structural adaptation of remnant small intestine: animal experiment. World J Gastroenterol 2001;7:66-73.
70. Dahly EM, Gillingham MB, Guo Z, et al. Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection. Am J Physiol Gastrointest Liver Physiol 2003;284:G670-82.
71. Buchman AL, Moukarzel AA, Ament ME, et al. Effects of total parenteral nutrition on intestinal morphology and function in humans. Transplant Proc 1994;26:1457.
72. van der Hulst RR, van Kreel BK, von Meyenfeldt MF, et al. Glutamine and the preservation of gut integrity. Lancet 1993;341:1363-5.
73. Gorard DA. Enterai nutrition in Crohn's disease: fat in the formula. Eur J Gastroenterol Hepatol 2003;15:115-18.
74. McIntyre PB, Fitchew M, Lennard-Jones JE. Patients with a high jejunostomy do not need a special diet. Gastroenterology 1986;91:25-33.
75. Cosnes J, Evard D, Beaugerie L, et al. Improvement in protein absorption with a small-peptide-based diet in patients with high jejunostomy. Nutrition 1992;8:406-11.
76. Nelson LM, Russell RI, Lee FD. Elemental diet composition and the structure and function of rat small intestine: comparison of the effects of two diets on morphology and in vivo absorption of water. JPEN J Parenter Enteral Nutr 1981;5:204-6.
77. Evers BM, Izukura M, Townsend CM Jr, et al. Neurotensin prevents intestinal mucosal hypoplasia in rats fed an elemental diet. Dig Dis Sci 1992;37:426-31.
78. Shulman DI, Hu CS, Duckett G, et al. Effects of short-term growth hormone therapy in rats undergoing 75% small intestinal resection. J Pediatr Gastroenterol Nutr 1992;14:3-11.
79. Benhamou PH, Canarelli JP, Leroy C, et al. Stimulation by recombinant human growth hormone of growth and development of remaining bowel after subtotal ileojejunectomy in rats. J Pediatr Gastroenterol Nutr 1994;18:446-52.
80. Wheeler EE, Challacombe DN. The trophic action of growth hormone, insulin-like growth factor-I, and insulin on human duodenal mucosa cultured in vitro. Gut 1997;40:57-60.
81. Lund PK. Molecular basis of intestinal adaptation: the role of the insulin-like growth factor system. Ann N Y Acad Sci 1998;859:18-36.
82. Ryan J, Costigan DC. Determination of the histological distribution of insulin like growth factor 1 receptors in the rat gut. Gut 1993;34:1693-7.
83. Furstenberger G, Senn HJ. Insulin-like growth factors and cancer. Lancet Oncol 2002;3:298-302.
84. Peterson CA, Carey HV, Hinton PL, et al. GH elevates serum IGF-I levels but does not alter mucosal atrophy in parenterally fed rats. Am J Physiol 1997;272:G1100-8.
85. Ziegler TR, Mantell MP, Chow JC, et al. Gut adaptation and the insulin-like growth factor system: regulation by glutamine and IGF-I administration. Am J Physiol 1996;271:G866-75.
86. Peterson CA, Gillingham MB, Mohapatra NK, et al. Enterotrophic effect of insulin-like growth factor-I but not growth hormone and localized expression of insulin-like growth factor-I, insulin-like growth factor binding protein-3 and -5 mRNAs in jejunum of parenterally fed rats. JPEN J Parenter Enteral Nutr 2000;24:288-95.
87. Kuemmerle JF, Zhou H. Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates growth and IGF-I secretion in human intestinal smooth muscle by Ras-dependent activation of p38 MAP kinase and Erk1/2 pathways. J Biol Chem 2002;277:20563-71.
88. Hankinson SE, Willett WC, Colditz GA, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 1998;351:1393-6.
89. Chan JM, Stampfer MJ, Giovannucci E, et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 1998;279:563-6.
90. Ma J, Pollak MN, Giovannucci E, et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst 1999;91:620-5.
91. Lukanova A, Toniolo P, Akhmedkhanov A, et al. A prospective study of insulin-like growth factor-I, IGF-binding proteins-1, -2 and -3 and lung cancer risk in women. Int J Cancer 2001;92:888-92.
92. Drucker DJ, DeForest L, Brubaker PL. Intestinal response to growth factors administered alone or in combination with human [Gly2]glucagon-like peptide 2. Am J Physiol 1997;273:G1252-62.
93. Iwamoto R, Mekada E. Heparin-binding EGF-like growth factor: a juxtacrine growth factor. Cytokine Growth Factor Rev 2000;11:335-44.
94. Howarth GS, Shoubridge CA. Enhancement of intestinal growth and repair by growth factors. Curr Opin Pharmacol 2001;1:568-74.
95. Welters CF, Dejong CH, Deutz NE, Heineman E. Intestinal adaptation in short bowel syndrome. Aust N Z J Surg 2002;72:229-36.
96. Shin CE, Helmrath MA, Falcone RA Jr, et al. Epidermal growth factor augments adaptation following small bowel resection: optimal dosage, route, and timing of administration. J Surg Res 1998;77:11-16.
97. Erwin CR, Helmrath MA, Shin CE, et al. Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection. Am J Physiol 1999;277:G533-40.
98. Helmrath MA, Shin CE, Fox JW, et al. Adaptation after small bowel resection is attenuated by sialoadenectomy: the role for endogenous epidermal growth factor. Surgery 1998;124:848-54.
99. O'Brien DP, Nelson LA, Williams JL, et al. Selective inhibition of the epidermal growth factor receptor impairs intestinal adaptation after small bowel resection. J Surg Res 2002;105:25-30.
100. Murphy MS. Growth factors and the gastrointestinal tract. Nutrition 1998;14:771-4.
101. Malden LT, Novak U, Burgess AW. Expression of transforming growth factor alpha messenger RNA in the normal and neoplastic gastro-intestinal tract. Int J Cancer 1989;43:380-4.
102. Sukhotnik I, Yakirevich E, Coran AG, et al. Effect of transforming growth factor-alpha on intestinal adaptation in a rat model of short bowel syndrome. J Surg Res 2002;108:235-42.
103. Higashiyama S, Abraham JA, Miller J, et al. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 1991;251:936-9.
104. Xia G, Martin AE, Michalsky MP, et al. Heparin-binding EGF-like growth factor preserves crypt cell proliferation and decreases bacterial translocation after intestinal ischemia/reperfusion injury. J Pediatr Surg 2002;37:1081-7.
105. Ellis PD, Hadfield KM, Pascall JC, et al. Heparin-binding epidermal-growth-factor-like growth factor gene expression is induced by scrape-wounding epithelial cell monolayers: involvement of mitogen-activated protein kinase cascades. Biochem J 2001;354:99-106.
106. Mulligan C, Rochford J, Denyer G, et al. Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1. J Biol Chem 2002;277:42480-7.
107. Holst JJ. Enteroglucagon. Annu Rev Physiol 1997;59:257-71.
108. Drucker DJ, Erlich P, Asa SL, et al. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci USA 1996;93:7911-16.
109. Jasleen J, Ashley SW, Shimoda N, et al. Glucagon-like peptide 2 stimulates intestinal epithelial proliferation in vitro. Dig Dis Sci 2002;47:1135-40.
110. Scott RB, Kirk D, MacNaughton WK, et al. GLP-2 augments the adaptive response to massive intestinal resection in rat. Am J Physiol 1998;275:G911-21.
111. Yusta B, Huang L, Munroe D, et al. Enteroendocrine localization of GLP-2 receptor expression in humans and rodents. Gastroenterology 2000;119:744-55.
112. Jeppesen PB, Hartmann B, Hansen BS, et al. Impaired meal stimulated glucagon-like peptide 2 response in ileal resected short bowel patients with intestinal failure. Gut 1999;45:559-63.
113. Kata Y, Yu D, Schwartz MZ. Enhancement of intestinal adaptation by hepatocyte growth factor. J Pediatr Surg 1998;33:235-9.
114. Kata Y, Yu D, Schwartz MZ. Hepatocyte growth factor up-regulates SGLT1 and GLUT5 gene expression after massive small bowel resection. J Pediatr Surg 1998;33:13-15.
115. Wildhaber BE, Yang H, Teitelbaum DH. Total parenteral nutrition-induced apoptosis in mouse intestinal epithelium: modulation by keratinocyte growth factor. J Surg Res 2003;112:144-51.
116. Yang H, Antony PA, Wildhaber BE, et al. Intestinal intraepithelial lymphocyte gammadelta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse. J Immunol 2004;172:4151-8.
117. Johnson WF, DiPalma CR, Ziegler TR, et al. Keratinocyte growth factor enhances early gut adaptation in a rat model of short bowel syndrome. Vet Surg 2000;29:17-27.
118. Yang H, Wildhaber BE, Teitelbaum DH. 2003 Harry M. Vars Research Award. Keratinocyte growth factor improves epithelial function after massive small bowel resection. JPEN J Parenter Enteral Nutr 2003;27:198-206.
119. Izukura M, Evers BM, Parekh D, et al. Neurotensin augments intestinal regeneration after small bowel resection in rats. Ann Surg 1992;215:520-6.
120. De Miguel E, Gomez dS I, Bonet H, et al. Trophic effects of neurotensin in massive bowel resection in the rat. Dig Dis Sci 1994;39:59-64.
121. Pearson PY, O'Connor DM, Schwartz MZ. Novel effect of leptin on small intestine adaptation. J Surg Res 2001;97:192-5.
122. Lostao MP, Urdaneta E, Martinez-Anso E, et al. Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption. FEBS Lett 1998;423:302-6.
123. Alavi K, Schwartz MZ, Prasad R, et al. Leptin: a new growth factor for the small intestine. J Pediatr Surg 2002;37:327-30.
124. Du X, Williams DA. Interleukin-11: review of molecular, cell biology, and clinical use. Blood 1997;89:3897-908.
125. Orazi A, Du X, Yang Z, et al. Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation. Lab Invest 1996;75:33-42.
126. Gibson RJ, Keefe DM, Thompson FM, et al. Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats. Dig Dis Sci 2002;47:2751-7.
127. Fiore NF, Ledniczky G, Liu Q, et al. Comparison of interleukin-11 and epidermal growth factor on residual small intestine after massive small bowel resection. J Pediatr Surg 1998;33:24-9.
128. Alavi K, Prasad R, Lundgren K, et al. Interleukin-11 enhances small intestine absorptive function and mucosal mass after intestinal adaptation. J Pediatr Surg 2000;35:371-4.
129. Byrne TA, Persinger RL, Young LS, et al. A new treatment far patients with short-bowel syndrome. Growth hormone, glutamine, and a modified diet. Ann Surg 1995;222:243-54.
130. Byrne TA, Morrissey TB, Nattakom TV, et al. Growth hormone, glutamine, and a modified diet enhance nutrient absorption in patients with severe short bowel syndrome. JPEN J Parenter Enteral Nutr 1995;19:296-302.
131. Byrne TA, Cox S, Karimbakas M, et al. Bowel rehabilitation: an alternative to long-term parenteral nutrition and intestinal transplantation for some patients with short bowel syndrome. Transplant Proc 2002;34:887-90.
132. Scolapio JS, Camilleri M, Fleming CR, et al. Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: a randomized, controlled study. Gastroenterology 1997;113:1074-81.
133. Scolapio JS. Effect of growth hormone, glutamine, and diet on body composition in short bowel syndrome: a randomized, controlled study. JPEN J Parenter Enteral Nutr 1999;23:309-12.
134. Szkudlarek J, Jeppesen PB, Mortensen PB. Effect of high dose growth hormone with glutamine and no change in diet on intestinal absorption in short bowel patients: a randomised, double blind, crossover, placebo controlled study. Gut 2000;47:199-205.
135. Seguy D, Vahedi K, Kapel N, et al. Low-dose growth hormone in adult home parenteral nutrition-dependent short bowel syndrome patients: a positive study. Gastroenterology 2003;124:293-302.
136. Jeppesen PB, Hartmann B, Thulesen J, et al. Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon. Gut 2000;47:370-6.
137. Jeppesen PB, Hartmann B, Thulesen J, et al. Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon. Gastroenterology 2001;120:806-15.