Selective inhibition of the epidermal growth factor receptor impairs intestinal adaptation after small bowel resection

Journal of Surgical Research

Volumn 105, Issue 1, 2002, Pages 25-30

  O'Brien, David P ^a,b   Nelson, Lindsey A ^a,b   Williams, Jodi L ^a,b   Kemp, Christopher J ^a,b   Erwin, Christopher R ^a,b   Warner, Brad W ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Epidermal growth factor receptor; Intestinal adaptation; Short bowel syndrome

Indexed keywords

CYCLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CRYPT CELL; ILEUM; INTESTINE CRYPT; INTESTINE FUNCTION; INTESTINE VILLUS; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SMALL INTESTINE RESECTION; WESTERN BLOTTING;

EID: 0036292301     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2002.6440     Document Type: Article

References (21)

1. Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium
2. The distribution of endogenous epidermal growth factor after small bowel resection suggests increased intestinal utilization during adaptation
3. Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression
4. Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection
5. A defective EGF-receptor in waved-2 mice attenuates intestinal adaptation
6. Adaptation after small bowel resection is attenuated by sialoadenectomy: The role for endogenous epidermal growth factor
7. Pharmacokinetics and tolerability of the orally active selective epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in healthy volunteers
8. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
9. Intestinal adaptation following massive small bowel resection in the mouse
10. Enterocyte apoptosis is increased following small bowel resection
11. Protein measurement with the Folin phenol reagant
12. Epidermal growth factor upregulates the expression of its own intestinal receptor after small bowel resection
13. ZD1839 ('Iressa') as an anti-cancer agent
14. ZD1839 ('Iressa') a selective epidermal growth factor receptor tyrosine kinase (EGFR-TKI): Inhibition of c-fos mRNA, an intermediate marker of EGFR activation, correlates with tumor growth inhibition
15. The expression and activation of EGF and c-NEU receptors are increased in enterocytes during intestinal adaptation
16. GLP-2 augments the adaptive response to massive intestinal resection in rat
17. Growth-factor enhancement of compromised gut function following massive small-bowel resection
18. Keratinocyte growth factor enhances early gut adaptation in a rat model of short bowel syndrome
19. Interleukin-11 enhances small intestine absorptive function and mucosal mass after intestinal adaptation
20. Epidermal growth factor alters the bax:bcl-w ratio following massive small bowel resection